公开(公告)号：EP1534703A2

公开(公告)日：2005-06-01

申请号：EP03760268.7

申请日：2003-06-11

Applicant: ABBOTT LABORATORIES

Inventor： BLACKBURN, Christopher ,  LAI, Su-jen ,  LEE, Jennifer, G. ,  MAGUIRE, Martin ,  PATANE, Michael, A. ,  LAMARCHE, Matthew, J. ,  CULLIS, Courtney, A. ,  BROWN, James ,  VASUDEVAN, Anil ,  FREEMAN, Jennifer, C. ,  MULHERN, Mathew, M. ,  LYNCH, John, K. ,  GAO, Ju ,  WODKA, Dariusz ,  SOUERS, Andrew, J. ,  IYENGAR, Rajesh

IPC: C07D405/00

CPC classification number: C07D405/14 ,  C07D401/14 ,  C07D405/12 ,  C07D409/14 ,  C07D413/14

Abstract: This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula (I): where m is zero or one, n is zero to two, Y is oxygen or -N (R )-, R , R , R , R , R , R , and Ring A are defined in the specification. Coumarin and quinolone compounds where R and R together form a fused benzo ring are preferred. The invention also provides compounds of formula (VI) where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.