公开(公告)号：WO2009067579A1

公开(公告)日：2009-05-28

申请号：PCT/US2008/084148

申请日：2008-11-20

Applicant: ABBOTT LABORATORIES ,  JI, Jianguo ,  LI, Tao ,  SIPPY, Kevin B ,  LEE, Chih-Hung ,  GOPALAKRISHNAN, Murali

Inventor： JI, Jianguo ,  LI, Tao ,  SIPPY, Kevin B ,  LEE, Chih-Hung ,  GOPALAKRISHNAN, Murali

IPC: C07D451/04 ,  C07D451/06 ,  A61K31/46 ,  A61P25/00

CPC classification number: C07D451/04 ,  A61K31/46 ,  C07D451/06

Abstract: The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及联芳基取代的氮杂二环烷烃衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2003070247A1

公开(公告)日：2003-08-28

申请号：PCT/US2003/004187

申请日：2003-02-11

Applicant: ABBOTT LABORATORIES

Inventor： LEE, Chih-Hung ,  BAYBURT, Erol, K. ,  DIDOMENICO, Stanley, Jr. ,  DRIZIN, Irene ,  GOMTSYAN, Arthur, R. ,  KOENIG, John, R. ,  PERNER, Richard, J. ,  SCHMIDT, Robert, G. ,  TURNER, Sean, C. ,  WHITE, Tammie, K. ,  ZHENG, Guo, Zhu

IPC: A61K31/502

CPC classification number: C07D249/08 ,  A61K31/404 ,  A61K31/416 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07D209/08 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D217/26 ,  C07D231/12 ,  C07D231/56 ,  C07D233/56 ,  C07D237/28 ,  C07D401/12 ,  C07D405/12

Abstract: Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

Abstract translation: 式（I）化合物是可用于治疗疼痛，炎症性热痛觉过敏，尿失禁和膀胱过度活动的新型VR1拮抗剂。

公开(公告)号：WO2007050732A1

公开(公告)日：2007-05-03

申请号：PCT/US2006/041739

申请日：2006-10-27

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur, R. ,  BAYBURT, Erol, K. ,  KOENIG, John, R. ,  MARSH, Kennan, C. ,  SCHMIDT, Robert, G., Jr. ,  LEE, Chih-Hung ,  WANG, Weili ,  DAANEN, Jerome, F. ,  BROWN, Brian, S.

Inventor： GOMTSYAN, Arthur, R. ,  BAYBURT, Erol, K. ,  KOENIG, John, R. ,  MARSH, Kennan, C. ,  SCHMIDT, Robert, G., Jr. ,  LEE, Chih-Hung ,  WANG, Weili ,  DAANEN, Jerome, F. ,  BROWN, Brian, S.

IPC: C07D231/56 ,  C07D407/12 ,  A61K31/416 ,  A61P13/00

CPC classification number: C07D405/12 ,  C07D231/56 ,  C07D403/12 ,  C07F9/65038

Abstract: Compounds of formula (I), wherein A, R 1 , R 2 , and R 3 are defined in the specification, and which are useful as therapeutic compounds particularly for treating disorders or conditions associated with inflammation, pain, bladder overactivity, urinary incontinence, and other disorders caused by or exacerbated by TRPV1.

Abstract translation: 其中A，R 1，R 2和R 3的式（I）化合物在说明书中定义，并且它们是有用的 作为特别用于治疗与炎症，疼痛，膀胱过度活动，尿失禁以及由TRPV1引起或加剧的其它障碍有关的疾病或病症的治疗性化合物。

公开(公告)号：WO2006122250A2

公开(公告)日：2006-11-16

申请号：PCT/US2006/018256

申请日：2006-05-10

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur ,  PERNER, Richard ,  KOENIG, John ,  HSU, Margaret Chi-Ping ,  FERNANDO, Dilini ,  LEE, Chih-Hung

Inventor： GOMTSYAN, Arthur ,  PERNER, Richard ,  KOENIG, John ,  HSU, Margaret Chi-Ping ,  FERNANDO, Dilini ,  LEE, Chih-Hung

IPC: C07D263/48 ,  A61K31/421 ,  A61P29/00

CPC classification number: C07D263/48

Abstract: The present invention is directed to compounds of formula (I) (I) wherein variables W, X, Y, D, A, n, R1, R2 and R9 are as defined in the description.

Abstract translation: 本发明涉及式（I）（I）的化合物，其中变量W，X，Y，D，A，n，R 1，R 2和R 9如说明书中所定义。

公开(公告)号：WO2012134943A1

公开(公告)日：2012-10-04

申请号：PCT/US2012/030096

申请日：2012-03-22

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur ,  DAANEN, Jerome F. ,  GFESSER, Gregory A. ,  KORT, Michael R. ,  LEE, Chih-Hung ,  MCDONALD, Heath A. ,  PUTTFARCKEN, Pamela S. ,  VOIGHT, Eric A. ,  KYM, Phil

Inventor： GOMTSYAN, Arthur ,  DAANEN, Jerome F. ,  GFESSER, Gregory A. ,  KORT, Michael R. ,  LEE, Chih-Hung ,  MCDONALD, Heath A. ,  PUTTFARCKEN, Pamela S. ,  VOIGHT, Eric A. ,  KYM, Phil

IPC: C07C275/32 ,  C07D231/54 ,  C07D413/12 ,  A61K31/17 ,  A61K31/416 ,  A61P13/10 ,  A61P25/04 ,  A61P29/00

CPC classification number: C07C275/32 ,  C07C2601/08 ,  C07C2602/08 ,  C07D209/08 ,  C07D215/38 ,  C07D217/02 ,  C07D231/56 ,  C07D239/80 ,  C07D263/48 ,  C07D265/36 ,  C07D401/04 ,  C07D413/12 ,  C07D417/12

Abstract: Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, or combinations thereof, (I) wherein X 1 , X 2 , X 3 , X 4 , J, K, L, X 5 , X 6 , R b , G 2 , and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，溶剂化物或其组合，其中X1，X2，X3，X4，J，K，L，X5，X6，Rb，G2和m被定义 在规范中。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2010151815A3

公开(公告)日：2010-12-29

申请号：PCT/US2010/040064

申请日：2010-06-25

Applicant: ABBOTT LABORATORIES ,  SCHRIMPF, Michael R. ,  NERSESIAN, Diana L. ,  LEE, Chih-Hung ,  FAGHIH, Ramin ,  GFESSER, Gregory A.

Inventor： SCHRIMPF, Michael R. ,  NERSESIAN, Diana L. ,  LEE, Chih-Hung ,  FAGHIH, Ramin ,  GFESSER, Gregory A.

IPC: C07D487/10 ,  C07D471/02 ,  A61K31/438 ,  A61P25/28

Abstract: Compounds of formula (I) are useful in treating conditions or disorders ameliorated by α4β2 postive allosteric modulators. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.

公开(公告)号：WO2009100294A2

公开(公告)日：2009-08-13

申请号：PCT/US2009/033329

申请日：2009-02-06

Applicant: ABBOTT LABORATORIES ,  MORTELL, Kathleen H. ,  NERSESIAN, Diana L. ,  SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  GOPALAKRISHNAN, Murali

Inventor： MORTELL, Kathleen H. ,  NERSESIAN, Diana L. ,  SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  GOPALAKRISHNAN, Murali

IPC: C07D401/12

CPC classification number: C07D401/12 ,  C07D209/08 ,  C07D403/12 ,  C07D471/04

Abstract: The invention relates to novel amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.

Abstract translation: 本发明涉及作为神经元烟碱性受体的PAM的新型酰胺衍生物，包含该酰胺衍生物的组合物，制备该化合物的方法，以及使用这些化合物和组合物的方法。

公开(公告)号：WO2007121299A2

公开(公告)日：2007-10-25

申请号：PCT/US2007/066515

申请日：2007-04-12

Applicant: ABBOTT LABORATORIES ,  BROWN, Brian S. ,  KOENIG, John R. ,  GOMTSYAN, Arthur R. ,  LEE, Chih-Hung

Inventor： BROWN, Brian S. ,  KOENIG, John R. ,  GOMTSYAN, Arthur R. ,  LEE, Chih-Hung

IPC: A61K31/519 ,  A61K31/4747 ,  C07D498/10

CPC classification number: C07D491/107 ,  C07D405/12 ,  C07D493/10

Abstract: The present invention is directed to compounds of formula (I), wherein variables X 1 , X 2 , Y, R 1a , R1 b , R 2a , R 2b , A 1 , A 2 , A 3 , and A 4 are as defined in the description, and methods of use to treat pain, neuropathic pain, allodynia, pain associated with inflammation or an inflammatory disease, inflammatory hyperalgesia, bladder overactivity, and urinary incontinence.

Abstract translation: 本发明涉及式（I）化合物，其中X 1，X 2，Y，R 1a，R 1， R b，R 2b，R 2b，A 1，A 2，A SUB， > 3 和A 4 <4>如描述中所定义，以及用于治疗疼痛，神经性疼痛，异常性疼痛，与炎症或炎性疾病相关的疼痛，炎性痛觉过敏，膀胱 过度活动和尿失禁。

公开(公告)号：WO2005007642A2

公开(公告)日：2005-01-27

申请号：PCT/US2004/021836

申请日：2004-07-09

Applicant: ABBOTT LABORATORIES ,  ZHENG, Guo Zhu ,  BROWN, Brian, S. ,  TURNER, Sean, C. ,  WHITE, Tammie, K. ,  SCHMIDT, Robert, G. ,  KOENIG, John, R. ,  LEE, Chih-Hung

Inventor： ZHENG, Guo Zhu ,  BROWN, Brian, S. ,  TURNER, Sean, C. ,  WHITE, Tammie, K. ,  SCHMIDT, Robert, G. ,  KOENIG, John, R. ,  LEE, Chih-Hung

IPC: C07D401/04

CPC classification number: C07D401/04 ,  C07D487/08

Abstract: The present invention relates to compounds of formula (I-VII) (I), or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R 6 , R 7 and R 8 are defined herein. The present invention also relates to methods of trating pain using these compounds and pharmaceutical compositions including these compounds.

Abstract translation: 本发明涉及式（I-VII）（I）化合物或其药学上可接受的盐或前药，其中A，L，R 6，R 7和R 8如本文所定义。 本发明还涉及使用这些化合物和包括这些化合物的药物组合物来治疗疼痛的方法。

公开(公告)号：WO2011008312A2

公开(公告)日：2011-01-20

申请号：PCT/US2010/027931

申请日：2010-03-19

Applicant: ABBOTT LABORATORIES ,  SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  LI, Tao ,  GFESSER, Gregory A. ,  MORTELL, Kathleen H. ,  FAGHIH, Ramin ,  NERSESIAN, Diana L. ,  SIPPY, Kevin B. ,  BUNNELLE, William H. ,  SCANIO, Marc ,  SHI, Lei ,  GOPALAKRISHNAN, Murali ,  DONNELLY-ROBERTS, Diana L. ,  HU, Min

Inventor： SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  LI, Tao ,  GFESSER, Gregory A. ,  MORTELL, Kathleen H. ,  FAGHIH, Ramin ,  NERSESIAN, Diana L. ,  SIPPY, Kevin B. ,  BUNNELLE, William H. ,  SCANIO, Marc ,  SHI, Lei ,  GOPALAKRISHNAN, Murali ,  DONNELLY-ROBERTS, Diana L. ,  HU, Min

IPC: C07D487/18

CPC classification number: C07D471/18 ,  C07D487/18

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a , R 1 , R 2 , R 3 , R 4 , R 5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和吲哚啉衍生物， R 1，R 2，R 3，R 4，R 5，R 5，R 5，R 4， U，V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含此类化合物的组合物，以及使用此类化合物和组合物治疗疾病状况的方法以及鉴定此类化合物的方法。