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公开(公告)号：WO2008073942A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/087090
申请日：2007-12-12
Applicant: ABBOTT LABORATORIES , GOPALAKRISHNAN, Murali , HONORE, Marie, P. , LEE, Chih-hung , MALYSZ, John , JI, Jianguo , LI, Tao , SCHRIMPF, Michael, R. , SIPPY, Kevin, B. , ANDERSON, David, J.
Inventor： GOPALAKRISHNAN, Murali , HONORE, Marie, P. , LEE, Chih-hung , MALYSZ, John , JI, Jianguo , LI, Tao , SCHRIMPF, Michael, R. , SIPPY, Kevin, B. , ANDERSON, David, J.
IPC: A61K31/4245 , A61P25/28 , A61K45/06
CPC classification number: A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
Abstract translation: 本发明涉及包含神经元烟碱性受体配体和a4β2正变构调节剂的组合物，其使用方法和相关制品。
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2.发明申请AZA-CYLIC INDOLE- 2 -CARBOXAMIDES AND METHODS OF USE THEREOF 审中-公开AZA-CYLIC INDOLE-2 -CARBOXAMIDES及其使用方法
公开(公告)号：WO2009158375A1
公开(公告)日：2009-12-30
申请号：PCT/US2009/048380
申请日：2009-06-24
Applicant: ABBOTT LABORATORIES , GOPALAKRISHNAN, Murali , JI, Jianguo , LEE, Chih-hung , LI, Tao , SIPPY, Kevin, B.
Inventor： GOPALAKRISHNAN, Murali , JI, Jianguo , LEE, Chih-hung , LI, Tao , SIPPY, Kevin, B.
IPC: C07D401/12 , C07D403/12 , A61K31/454 , A61K31/404 , A61K31/55
CPC classification number: C07D401/12 , A61K31/404 , A61K31/454 , A61K31/55 , A61K45/06 , C07D403/12 , A61K2300/00
Abstract: The invention relates to aza-cyclic indole-2-carboxamide derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions.
Abstract translation: 本发明涉及氮杂环吲哚-2-甲酰胺衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物预防或治疗病症和障碍的方法。
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公开(公告)号：WO2008079570A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/085566
申请日：2007-11-27
Applicant: ABBOTT LABORATORIES , JI, Jianguo , SCHRIMPF, Michael R , SIPPY, Kevin B , LI, Tao , LEE, Chih-hung
Inventor： JI, Jianguo , SCHRIMPF, Michael R , SIPPY, Kevin B , LI, Tao , LEE, Chih-hung
IPC: C07D471/18 , A61K31/395 , A61P25/02 , A61P25/28
CPC classification number: C07D471/18
Abstract: The invention relates to compounds that are spirocyclic azaadamantane derivatives (I), particularly spirocyclic, azaadamantanyl ether or amine derviatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
Abstract translation: 本发明涉及作为螺环氮杂金刚烷衍生物（I），特别是螺环，氮杂金刚烷基醚或胺衍生物的化合物，包含这些化合物的组合物，使用这些化合物和组合物的方法，制备这些化合物的方法以及在这些方法中获得的中间体。
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公开(公告)号：WO2008058096A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/083687
申请日：2007-11-06
Applicant: ABBOTT LABORATORIES , SCHRIMPF, Michael R , NERSESIAN, Diana L , SIPPY, Kevin B , JI, Jianguo , LI, Tao , SCANIO, Marc , SHI, Lei , LEE, Chih-hung , BUNNELLE, Willaim H , ZHANG, Geoff G.Z. , BRACKEMEYER, Paul J , CHEN, Shuang , HENRY, Rodger F
Inventor： SCHRIMPF, Michael R , NERSESIAN, Diana L , SIPPY, Kevin B , JI, Jianguo , LI, Tao , SCANIO, Marc , SHI, Lei , LEE, Chih-hung , BUNNELLE, Willaim H , ZHANG, Geoff G.Z. , BRACKEMEYER, Paul J , CHEN, Shuang , HENRY, Rodger F
IPC: C07D451/14 , A61K31/395
CPC classification number: C07D471/18 , A61K31/095 , A61K31/439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07C309/29 , C07D451/14 , C07D471/08 , C07F5/022
Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
Abstract translation: 本发明涉及为氮杂金刚烷衍生物，特别是醚或胺取代的氮杂金刚烷衍生物及其盐和前药的化合物，包含此类化合物的组合物，使用此类化合物和组合物的方法，制备这类化合物的方法 化合物和在这些过程中获得的中间体。
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5.发明申请THIENOPYRIDYL COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USES THEREOF 审中-公开抑制VANILLOID受体亚型1（VR1）的三烯丙基化合物及其用途
公开(公告)号：WO2006063178A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/044500
申请日：2005-12-07
Applicant: ABBOTT LABORATORIES , TURNER, Sean, C. , JINKERSON, Tammie, K. , GOMTSYAN, Arthur, R. , LEE, Chih-hung
Inventor： TURNER, Sean, C. , JINKERSON, Tammie, K. , GOMTSYAN, Arthur, R. , LEE, Chih-hung
IPC: C07D495/04 , A61K31/4365 , A61P13/10 , A61P29/00
CPC classification number: C07D495/04 , C07D498/04
Abstract: The present invention discloses fused thienopyridyl compounds of general formula (I), wherein X 1 -X 6 , R 5 -R 7 , Z 1 and L are as defined in the description. The resent invention also discloses a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain, urinary incontinence, bladder overactivity, and inflammatory thermal hyperalgesia in mammals, and pharmaceutical compositions including those compounds.
Abstract translation: 本发明公开了通式（I）的稠合噻吩并吡啶基化合物，其中X 1 -X 6 -X 6，R 5 -R 7 Z 1，L 1和L如说明书中所定义。 本发明还公开了使用这些化合物抑制哺乳动物中的VR1受体的方法，用于控制哺乳动物中的疼痛，尿失禁，膀胱过度活动和炎性热痛觉过敏的方法，以及包括那些化合物的药物组合物。
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Patent Agency Ranking
公开(公告)号：WO2009067586A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/084165
申请日：2008-11-20
Applicant: ABBOTT LABORATORIES , JI, Jianguo , LI, Tao , SIPPY, Kevin B , LEE, Chih-hung , GOPALAKRISHNAN, Murali
Inventor： JI, Jianguo , LI, Tao , SIPPY, Kevin B , LEE, Chih-hung , GOPALAKRISHNAN, Murali
IPC: C07D487/04 , A61K31/407 , A61P25/00
CPC classification number: C07D487/04
Abstract: The invention relates biaryl substituted diazabicycloalkanes of foraula (I), and more particularly bicycloheteroaryl substituted fused diazabicycloalkane derivatives, compositions comprising such compounds, and such compounds for use for treating or preventing conditions and disorders related to both
Abstract translation: 本发明涉及式（I）的联芳基取代的二氮杂双环烷烃，更具体地是双环杂芳基取代的稠合二氮杂双环烷烃衍生物，包含这些化合物的组合物，以及用于治疗或预防与
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公开(公告)号：WO2008127464A1
公开(公告)日：2008-10-23
申请号：PCT/US2007/087091
申请日：2007-12-12
Applicant: ABBOTT LABORATORIES , LEE, Chih-hung , JI, Jianguo , LI, Tao , SCHRIMPF, Michael, R. , SIPPY, Kevin, B. , GOPALAKRISHNAN, Murali
Inventor： LEE, Chih-hung , JI, Jianguo , LI, Tao , SCHRIMPF, Michael, R. , SIPPY, Kevin, B. , GOPALAKRISHNAN, Murali
IPC: C07D413/14 , A61K31/4245 , A61P25/28
CPC classification number: C07D413/14
Abstract: The invention relates to heterocyclic derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions. The heterocyclic derivatives, more particularly can be substituted oxadiazole compounds and derivatives thereof.
Abstract translation: 本发明涉及杂环衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物预防或治疗病症和障碍的方法。 杂环衍生物，更特别地可以是取代的恶二唑化合物及其衍生物。
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公开(公告)号：WO2008024945A1
公开(公告)日：2008-02-28
申请号：PCT/US2007/076696
申请日：2007-08-24
Applicant: ABBOTT LABORATORIES , LEE, Chih-hung , BROWN, Brian, S. , PERNER, Richard, J. , DARBYSHIRE, John
Inventor： LEE, Chih-hung , BROWN, Brian, S. , PERNER, Richard, J. , DARBYSHIRE, John
IPC: C07D231/56 , A61K31/416 , A61P25/00
CPC classification number: A61K31/416 , C07D231/56
Abstract: Compounds of formula (I) wherein R 3 , R 7 , R 9 and L are defined in the description are TRPV1 antagonists that exhibit low inhibitory activity against CYP3A4. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 在描述中定义的其中R 3，R 7，R 9和L的式（I）的化合物是表现出低抑制性的TRPV1拮抗剂 对CYP3A4的活性。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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9.发明申请CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF 审中-公开抑制VANILLOID受体亚型1（VR1）受体的氯霉素化合物及其用途
公开(公告)号：WO2006065484A2
公开(公告)日：2006-06-22
申请号：PCT/US2005/042545
申请日：2005-11-22
Applicant: ABBOTT LABORATORIES , GOMTSYAN, Arthur, R. , BAYBURT, Erol, K. , SCHMIDT, Robert, G., Jr. , LEE, Chih-hung , BROWN, S. Brian , JINKERSON, K. Tammie , KOENIG, R. John , DAANEN, F. Jerome , LATSHAW, Steve
Inventor： GOMTSYAN, Arthur, R. , BAYBURT, Erol, K. , SCHMIDT, Robert, G., Jr. , LEE, Chih-hung , BROWN, S. Brian , JINKERSON, K. Tammie , KOENIG, R. John , DAANEN, F. Jerome , LATSHAW, Steve
CPC classification number: C07D405/12 , C07D401/12 , C07D403/12 , C07D413/12
Abstract: Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A 1 , A 2 , A 3 , A 4 , R 7 , R 8 , R 9 , X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.
Abstract translation: 作为VR1受体的拮抗剂的化合物，具有式（I）或其药学上可接受的盐，前药或其前体药物的盐，其中A 1，A 2， A 3，S 4，R 7，R 8，R 9， X，Y，Z，L，n和m如本文所定义，并且可用于通过抑制VR1受体而防止或改善的病症。
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公开(公告)号：EP2146985A1
公开(公告)日：2010-01-27
申请号：EP07865508.1
申请日：2007-12-12
Applicant: ABBOTT LABORATORIES
Inventor： LEE, Chih-hung , JI, Jianguo , LI, Tao , SCHRIMPF, Michael, R. , SIPPY, Kevin, B. , GOPALAKRISHNAN, Murali
IPC: C07D413/14 , A61K31/4245 , A61P25/28
CPC classification number: C07D413/14
Abstract: The invention relates to heterocyclic derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions. The heterocyclic derivatives, more particularly can be substituted oxadiazole compounds and derivatives thereof.
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