公开(公告)号：WO1997046554A1

公开(公告)日：1997-12-11

申请号：PCT/US1997009167

申请日：1997-06-04

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LIN, Nan-Horng ,  HE, Yun ,  HOLLADAY, Mark, W. ,  RYTHER, Keith ,  LI, Yihong ,  BAI, Hao

IPC: C07D401/12

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of formula (I) or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula (I) with the variables defined in the specification are also described.

Abstract translation: 式（I）的新型3-吡啶氧基甲基杂环醚化合物或其药学上可接受的盐或前药是神经元烟碱胆碱能通道受体的选择性和有效配体，并且有效控制突触传递。 还描述了使用这种关键中间体用式（I）化合物与说明书中定义的变量的关键中间体和方法。

公开(公告)号：EP1047690A1

公开(公告)日：2000-11-02

申请号：EP98964167.5

申请日：1998-12-18

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  ABREO, Melwyn, A. ,  GUNN, David, E. ,  LIN, Nan-Horng ,  GARVEY, David, S. ,  RYTHER, Keith ,  LEBOLD, Suzanne, A. ,  ELLIOTT, Richard, L. ,  HE, Yun ,  WASIAK, James, T. ,  BAI, Hao ,  DART, Michael, J. ,  EHRLICH, Paul, P. ,  LI, Yihong ,  KINCAID, John, F. ,  SCHKERYANTZ, Jeffrey, M. ,  LYNCH, John, K.

IPC: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D455/02 ,  A61K31/44 ,  A61K31/40 ,  A61K31/425 ,  A61K31/50 ,  A61K31/505 ,  A61K31/47

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04

Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.

公开(公告)号：EP0934308A1

公开(公告)日：1999-08-11

申请号：EP97927830.0

申请日：1997-06-04

Applicant: Abbott Laboratories

Inventor： LIN, Nan-Horng ,  HE, Yun ,  HOLLADAY, Mark, W. ,  RYTHER, Keith ,  LI, Yihong ,  BAI, Hao

IPC: C07D401 ,  C07D405 ,  C07D409

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of formula (I) or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula (I) with the variables defined in the specification are also described.

公开(公告)号：EP0934308B1

公开(公告)日：2004-08-11

申请号：EP97927830.6

申请日：1997-06-04

Applicant: Abbott Laboratories

Inventor： LIN, Nan-Horng ,  HE, Yun ,  HOLLADAY, Mark, W. ,  RYTHER, Keith ,  LI, Yihong ,  BAI, Hao

IPC: C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  A61K31/44 ,  A61K31/445 ,  A61K31/465 ,  A61K31/505

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

公开(公告)号：EP1047690B1

公开(公告)日：2004-03-24

申请号：EP98964167.5

申请日：1998-12-18

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  ABREO, Melwyn, A. ,  GUNN, David, E. ,  LIN, Nan-Horng ,  GARVEY, David, S. ,  RYTHER, Keith ,  LEBOLD, Suzanne, A. ,  ELLIOTT, Richard, L. ,  HE, Yun ,  WASIAK, James, T. ,  BAI, Hao ,  DART, Michael, J. ,  EHRLICH, Paul, P. ,  LI, Yihong ,  KINCAID, John, F. ,  SCHKERYANTZ, Jeffrey, M. ,  LYNCH, John, K.

IPC: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D455/02 ,  A61K31/44 ,  A61K31/40 ,  A61K31/425 ,  A61K31/50 ,  A61K31/505 ,  A61K31/47

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04

Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.

公开(公告)号：EP1212319A2

公开(公告)日：2002-06-12

申请号：EP00965070.6

申请日：2000-09-14

Applicant: Abbott Laboratories

Inventor： LIN, Nan-Horng ,  LI, Yihong ,  DRIZIN, Irene ,  KINCAID, John, F. ,  BASHA, Anwer ,  DONG, Liming ,  HAKEEM, Ahmed, A.

IPC: C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  A61K31/4427 ,  A61P25/00

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D409/14

Abstract: A series of 3-pyrrolidinyloxy-3'-pyridyl ether compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions including these compounds. Preferred compounds are 3-pyrrolidinylmethoxy-3'-(5'-and/or 6'-substituted) pyridyl ethers.

公开(公告)号：EP0973777A1

公开(公告)日：2000-01-26

申请号：EP98913418.4

申请日：1998-04-10

Applicant: Abbott Laboratories

Inventor： ELLIOTT, Richard, L. ,  RYTHER, Keith, B. ,  HOLLADAY, Mark, W. ,  WASCIAK, James, T. ,  DAANEN, Jerome, F. ,  LIN, Nan-Horng ,  DART, Michael, J. ,  HE, Yun ,  LI, Yihong

IPC: C07D491/048 ,  A61K31/435 ,  C07D495/04 ,  C07D519/00

CPC classification number: C07D491/04 ,  A61K31/4355

Abstract: Novel heterocyclic ether compounds having formula (I) wherein A, m, R, X, Y?1, Y2 and Y3¿ are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.