DELIVERY SYSTEM FOR SUSTAINED RELEASE OF A CALCIUM -CHANNEL BLOCKING AGENT
    5.
    发明申请
    DELIVERY SYSTEM FOR SUSTAINED RELEASE OF A CALCIUM -CHANNEL BLOCKING AGENT 审中-公开
    用于持续释放钙通道阻断剂的输送系统

    公开(公告)号:WO2011042420A1

    公开(公告)日:2011-04-14

    申请号:PCT/EP2010/064804

    申请日:2010-10-05

    CPC classification number: A61K31/216 A61K9/0024 A61K9/146

    Abstract: A delivery system for sustained release of a calcium-channel blocking agent is adapted for introduction in the cerebrospinal fluid of a subject. The delivery system comprises a solid dispersion product of a calcium-channel blocking agent in a mixture of a (i) first poly(lactide-co-glycolide) having a molecular weight distribution centered around a first number average molecular weight Mn1 and a (ii) second poly(lactide-co- glycolide) having a molecular weight distribution centered around a second number average molecular weight Mn2, wherein Mn1 is in the range of from 2000 to 3000 g/mol and the ratio of Mn1/Mn2 is from 1.8 to 3.5. The delivery system is deposited in the vicinity of or adjacent to a blood vessel showing vasospasm or suspected of developing vasospasm.

    Abstract translation: 用于钙通道阻断剂持续释放的递送系统适于引入受试者的脑脊液中。 递送系统包括钙通道阻断剂在(i)第一聚(丙交酯 - 共 - 乙交酯)的混合物中的固体分散产物,其分子量分布围绕第一数均分子量Mn1和(ii )第二聚(丙交酯 - 共 - 乙交酯),其分子量分布以第二数均分子量Mn2为中心,其中Mn1为2000-3000g / mol,Mn1 / Mn2的比为1.8〜 3.5。 输送系统沉积在显示血管痉挛或怀疑发生血管痉挛的血管附近或邻近。

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