公开(公告)号：WO2004111009A1

公开(公告)日：2004-12-23

申请号：PCT/US2004/018590

申请日：2004-06-10

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur ,  BAYBURT, Erol, K. ,  LEE, Chih-Hung ,  KOENIG, John, R. ,  SCHMIDT, Robert ,  LUKIN, Kirill ,  CHAMBOURNIER, Gilles ,  HSU, Margaret ,  LEANNA, M., Robert ,  CINK, Russel, D.

Inventor： GOMTSYAN, Arthur ,  BAYBURT, Erol, K. ,  LEE, Chih-Hung ,  KOENIG, John, R. ,  SCHMIDT, Robert ,  LUKIN, Kirill ,  CHAMBOURNIER, Gilles ,  HSU, Margaret ,  LEANNA, M., Robert ,  CINK, Russel, D.

IPC: C07D217/02

CPC classification number: C07D403/12 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt or prodrug thereof (in which X 1 - X 5 , R 5 - R 8b , Z 1 - Z 2 and Ar 1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

Abstract translation: 本发明公开了通式（I）的新化合物或其药学上可接受的盐或前药（其中X1-X5，R5-R8b，Z1-Z2和Ar1如本文所定义），一种抑制VR1受体的方法 使用这些化合物的哺乳动物，用于控制哺乳动物疼痛的方法，以及包括这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：EP1658269B1

公开(公告)日：2008-10-22

申请号：EP04754996.9

申请日：2004-06-10

Applicant: ABBOTT LABORATORIES

Inventor： GOMTSYAN, Arthur ,  BAYBURT, Erol, K. ,  LEE, Chih-Hung ,  KOENIG, John, R. ,  SCHMIDT, Robert ,  LUKIN, Kirill ,  CHAMBOURNIER, Gilles ,  HSU, Margaret ,  LEANNA, M., Robert ,  CINK, Russel, D.

IPC: C07D217/02 ,  C07D231/56 ,  C07D403/12 ,  C07D401/12 ,  C07C211/42 ,  A61K31/472 ,  A61K31/416 ,  A61P13/10

CPC classification number: C07D403/12 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt or prodrug thereof (in which X1 - X5, R5 - R8b, Z1 - Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

公开(公告)号：EP1658269A1

公开(公告)日：2006-05-24

申请号：EP04754996.9

申请日：2004-06-10

Applicant: ABBOTT LABORATORIES

Inventor： GOMTSYAN, Arthur ,  BAYBURT, Erol, K. ,  LEE, Chih-Hung ,  KOENIG, John, R. ,  SCHMIDT, Robert ,  LUKIN, Kirill ,  CHAMBOURNIER, Gilles ,  HSU, Margaret ,  LEANNA, M., Robert ,  CINK, Russel, D.

IPC: C07D217/02 ,  C07D231/56 ,  C07D403/12 ,  C07D401/12 ,  C07C211/42 ,  A61K31/472 ,  A61K31/416 ,  A61P13/10

CPC classification number: C07D403/12 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt or prodrug thereof (in which X1 - X5, R5 - R8b, Z1 - Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.