公开(公告)号：EP0345627A3

公开(公告)日：1991-09-11

申请号：EP89109890.7

申请日：1989-06-01

Applicant: ABBOTT LABORATORIES

Inventor： Pariza, Richard J. ,  Maring, Clarence J. ,  Lartey, Paul A. ,  Klein, Larry L.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：EP0345627B1

公开(公告)日：1997-04-16

申请号：EP89109890.7

申请日：1989-06-01

Applicant: ABBOTT LABORATORIES

Inventor： Pariza, Richard J. ,  Maring, Clarence J. ,  Lartey, Paul A. ,  Klein, Larry L.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

公开(公告)号：EP0345627A2

公开(公告)日：1989-12-13

申请号：EP89109890.7

申请日：1989-06-01

Applicant: ABBOTT LABORATORIES

Inventor： Pariza, Richard J. ,  Maring, Clarence J. ,  Lartey, Paul A. ,  Klein, Larry L.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

Abstract translation: 公开了具有改善的治疗性能的半合成抗生素。 特别地，与其他大环内酯类化合物相比，红霉素，其衍生物及其盐和酯的9-R-氮杂环十二烷基衍生物显示出优异的抗菌活性。