公开(公告)号：EP0345627A3

公开(公告)日：1991-09-11

申请号：EP89109890.7

申请日：1989-06-01

Applicant: ABBOTT LABORATORIES

Inventor： Pariza, Richard J. ,  Maring, Clarence J. ,  Lartey, Paul A. ,  Klein, Larry L.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：EP0345627B1

公开(公告)日：1997-04-16

申请号：EP89109890.7

申请日：1989-06-01

Applicant: ABBOTT LABORATORIES

Inventor： Pariza, Richard J. ,  Maring, Clarence J. ,  Lartey, Paul A. ,  Klein, Larry L.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

公开(公告)号：EP0177696A1

公开(公告)日：1986-04-16

申请号：EP85109538.0

申请日：1985-07-29

Applicant: ABBOTT LABORATORIES

Inventor： Pariza, Richard J. ,  Freiberg, Leslie A.

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: O-Alkylated derivatives of macrolide antibiotics which exhibit improved antibiotic activity can be prepared from parent macrolides having a plurality of reactive hydroxyl groups via a two-step process involving, first, protective esterification of the hydroxy-amino sugar moiety, followed by alkylation at one or more of the remaining hydroxyl groups.

Abstract translation: 表现出改善的抗生素活性的大环内酯类抗生素的O-烷基化衍生物可以通过两步法由具有多个反应性羟基的亲本大环内酯制备，所述两步法首先将羟基 - 氨基糖部分进行保护性酯化，然后在一个 或更多的剩余羟基。

公开(公告)号：EP0345627A2

公开(公告)日：1989-12-13

申请号：EP89109890.7

申请日：1989-06-01

Applicant: ABBOTT LABORATORIES

Inventor： Pariza, Richard J. ,  Maring, Clarence J. ,  Lartey, Paul A. ,  Klein, Larry L.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

Abstract translation: 公开了具有改善的治疗性能的半合成抗生素。 特别地，与其他大环内酯类化合物相比，红霉素，其衍生物及其盐和酯的9-R-氮杂环十二烷基衍生物显示出优异的抗菌活性。