公开(公告)号：WO2002081441A1

公开(公告)日：2002-10-17

申请号：PCT/US2002/008074

申请日：2002-03-18

Applicant: ABBOTT LABORATORIES

Inventor： WITTENBERGER, Steven, J. ,  BHAGAVATULA, Lakshmi ,  DEGOEY, David, A. ,  DEMATTEI, John ,  HILL, David, R. ,  MCLAUGHLIN, Maureen, A. ,  GUPTA, Ashok, K. ,  MANNA, Sukumar ,  NICHOLS, Paul, J. ,  RAMIYA, Premchandran, H. ,  TIAN, Zhenping ,  RASMUSSEN, Michael, W.

IPC: C07D207/16

CPC classification number: C07D207/26 ,  C07D207/12 ,  C07D207/16

Abstract: A process for the preparation of neuraminidase inhibitors having structural formula (28) or therapeutically acceptable salts thereof, in which R1 is alkyl, cycloalkyl, cycloalkylalkyl, or arylalkyl; R2 is alkyl, cycloalkyl, cycloalkylalkyl, or arylalkyl; R4 is alkyl, cycloalkyalkyl, or aryl-(C2-C4-alkyl); R10 is methyl, ethyl, iso-propyl, or vinyl; and R12 is hydrogen or alkyl and intermediates useful for the process are disclosed.

Abstract translation: 制备具有结构式（28）或其治疗上可接受的盐的神经氨酸酶抑制剂的方法，其中R 1是烷基，环烷基，环烷基烷基或芳基烷基; R2是烷基，环烷基，环烷基烷基或芳基烷基; R4是烷基，环烷基或芳基 - （C 2 -C 4 - 烷基）; 甲基，乙基，异丙基或乙烯基; 并且R 12是氢或烷基，并且公开了可用于该方法的中间体。

公开(公告)号：EP1192139A1

公开(公告)日：2002-04-03

申请号：EP00942823.6

申请日：2000-06-15

Applicant: Abbott Laboratories

Inventor： ALLEN, Michael, S. ,  PREMCHANDRAN, Ramiya, H. ,  CHANG, Sou-Jen ,  CONDON, Stephen ,  DEMATTEI, John, J. ,  KING, Steven, A. ,  KOLACZKOWSKI, Lawrence ,  MANNA, Sukumar ,  NICHOLS, Paul, J. ,  PATEL, Hemant, H. ,  PATEL, Subhash, R. ,  PLATA, Daniel, J. ,  STONER, Eric, J. ,  TIEN, Jien-Heh, J. ,  WITTENBERGER, Steven, J.

IPC: C07D215/14 ,  C07C69/96 ,  C07C68/06 ,  C07C271/12 ,  C07C269/06 ,  C07C43/303 ,  C07C33/03 ,  C07C47/22 ,  C07C57/04

CPC classification number: C07D215/14 ,  C07C68/06 ,  C07C69/96

Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.

公开(公告)号：EP1192139B1

公开(公告)日：2012-04-18

申请号：EP00942823.6

申请日：2000-06-15

Applicant: ABBOTT LABORATORIES

Inventor： ALLEN, Michael, S. ,  PREMCHANDRAN, Ramiya, H. ,  CHANG, Sou-Jen ,  CONDON, Stephen ,  DEMATTEI, John, J. ,  KING, Steven, A. ,  KOLACZKOWSKI, Lawrence ,  MANNA, Sukumar ,  NICHOLS, Paul J. ,  PATEL, Hemant, H. ,  PATEL, Subhash, R. ,  PLATA, Daniel, J. ,  STONER, Eric, J. ,  TIEN, Jien-Heh, J. ,  WITTENBERGER, Steven, J.

IPC: C07D215/14 ,  C07C69/96 ,  C07C68/06 ,  C07C271/12 ,  C07C269/06 ,  C07C43/303 ,  C07C33/03 ,  C07C47/22 ,  C07C57/04

CPC classification number: C07D215/14 ,  C07C68/06 ,  C07C69/96

Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.