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公开(公告)号：WO1997021685A1
公开(公告)日：1997-06-19
申请号：PCT/US1996020440
申请日：1996-12-06
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , SHAM, Hing, Leung , NORBECK, Daniel, W. , CHEN, Xiaoqi , BETEBENNER, David, A. , KEMPF, Dale, J. , HERRIN, Thomas, R. , KUMAR, Gondi, N. , CONDON, Stephen, L. , COOPER, Arthur, J. , DICKMAN, Daniel, A. , HANNICK, Steven, M. , KOLACZKOWSKI, Lawrence , OLIVER, Patricia, A. , PLATA, Daniel, J. , STENGEL, Peter, J. , STONER, Eric, J. , TIEN, Jieh-Heh, J. , LIU, Jih-Hua , PATEL, Ketan, M.
IPC: C07D239/10
CPC classification number: C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
Abstract: A compound of formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
Abstract translation: 公开了式（I）化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。
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Patent Agency Ranking
公开(公告)号：WO2004024707A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/028396
申请日：2003-09-10
Applicant: ABBOTT LABORATORIES
Inventor： KU, Yi-Yin , PU, Yu-Ming , COWART, Marlon, D. , GRIEME, Timothy, A. , GUPTA, Ashok, K. , PLATA, Daniel, J.
IPC: C07D307/81
CPC classification number: C07D405/04 , C07C253/30 , C07C255/53 , C07D307/81
Abstract: The present invention relates to processes for preparing amine substituted benzofurans, and more particularly 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile, and salts thereof. Compounds prepared by the processes of the invention have demonstrated activity as histamine-3 receptor ligands.
Abstract translation: 本发明涉及制备胺取代的苯并呋喃的方法，特别是4-（2- {2 - [（2R）-2-甲基-1-吡咯烷基]乙基} -1-苯并呋喃-5-基）苄腈，和 的盐。 通过本发明方法制备的化合物已经证明作为组胺-3受体配体的活性。
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3.发明公开
公开(公告)号：EP1192139A1
公开(公告)日：2002-04-03
申请号：EP00942823.6
申请日：2000-06-15
Applicant: Abbott Laboratories
Inventor： ALLEN, Michael, S. , PREMCHANDRAN, Ramiya, H. , CHANG, Sou-Jen , CONDON, Stephen , DEMATTEI, John, J. , KING, Steven, A. , KOLACZKOWSKI, Lawrence , MANNA, Sukumar , NICHOLS, Paul, J. , PATEL, Hemant, H. , PATEL, Subhash, R. , PLATA, Daniel, J. , STONER, Eric, J. , TIEN, Jien-Heh, J. , WITTENBERGER, Steven, J.
IPC: C07D215/14 , C07C69/96 , C07C68/06 , C07C271/12 , C07C269/06 , C07C43/303 , C07C33/03 , C07C47/22 , C07C57/04
CPC classification number: C07D215/14 , C07C68/06 , C07C69/96
Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
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公开(公告)号：EP0882024B1
公开(公告)日：2002-02-06
申请号：EP96944941.2
申请日：1996-12-06
Applicant: Abbott Laboratories
Inventor： SHAM, Hing, Leung , NORBECK, Daniel, W. , CHEN, Xiaoqi , BETEBENNER, David, A. , KEMPF, Dale, J. , HERRIN, Thomas, R. , KUMAR, Gondi, N. , CONDON, Stephen, L. , COOPER, Arthur, J. , DICKMAN, Daniel, A. , HANNICK, Steven, M. , KOLACZKOWSKI, Lawrence , OLIVER, Patricia, A. , PLATA, Daniel, J. , STENGEL, Peter, J. , STONER, Eric, J. , TIEN, Jieh-Heh, J. , LIU, Jih-Hua , PATEL, Ketan, M.
IPC: C07D239/10 , C07D239/22 , C07D207/26 , C07D241/08 , C07D263/22 , C07D233/32 , C07D207/40 , A61K31/415
CPC classification number: C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
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公开(公告)号：EP0882024A1
公开(公告)日：1998-12-09
申请号：EP96944941.0
申请日：1996-12-06
Applicant: Abbott Laboratories
Inventor： SHAM, Hing, Leung , NORBECK, Daniel, W. , CHEN, Xiaoqi , BETEBENNER, David, A. , KEMPF, Dale, J. , HERRIN, Thomas, R. , KUMAR, Gondi, N. , CONDON, Stephen, L. , COOPER, Arthur, J. , DICKMAN, Daniel, A. , HANNICK, Steven, M. , KOLACZKOWSKI, Lawrence , OLIVER, Patricia, A. , PLATA, Daniel, J. , STENGEL, Peter, J. , STONER, Eric, J. , TIEN, Jieh-Heh, J. , LIU, Jih-Hua , PATEL, Ketan, M.
IPC: C07D , C07D253 , A61K31 , A61K38 , A61K45 , A61P31 , A61P43 , C07C231 , C07C235 , C07C273 , C07C275 , C07D207 , C07D211 , C07D223 , C07D233 , C07D239 , C07D241 , C07D243 , C07D263 , C07D265 , C07D267 , C07D277 , C07D279 , C07D281 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D417
CPC classification number: C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
Abstract: A compound of formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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6.发明授权
公开(公告)号：EP1192139B1
公开(公告)日：2012-04-18
申请号：EP00942823.6
申请日：2000-06-15
Applicant: ABBOTT LABORATORIES
Inventor： ALLEN, Michael, S. , PREMCHANDRAN, Ramiya, H. , CHANG, Sou-Jen , CONDON, Stephen , DEMATTEI, John, J. , KING, Steven, A. , KOLACZKOWSKI, Lawrence , MANNA, Sukumar , NICHOLS, Paul J. , PATEL, Hemant, H. , PATEL, Subhash, R. , PLATA, Daniel, J. , STONER, Eric, J. , TIEN, Jien-Heh, J. , WITTENBERGER, Steven, J.
IPC: C07D215/14 , C07C69/96 , C07C68/06 , C07C271/12 , C07C269/06 , C07C43/303 , C07C33/03 , C07C47/22 , C07C57/04
CPC classification number: C07D215/14 , C07C68/06 , C07C69/96
Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
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