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1.发明申请A VARIANT HUMAN ALPHA-7 ACETYLCHOLINE RECEPTOR SUBUNIT, AND METHODS OF PRODUCTION AND USE THEREOF 审中-公开一种变体人类ALPHA-7乙酰胆碱受体亚型及其生产和使用方法
公开(公告)号：WO1998028331A2
公开(公告)日：1998-07-02
申请号：PCT/US1997023405
申请日：1997-12-22
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , BRIGGS, Clark, A. , GOPALAKRISHNAN, Murali , MCKENNA, David, G. , MONTEGGIA, Lisa, M. , ROCH, Jean-Marc , SULLIVAN, James, P. , TOUMA, Edward
IPC: C07K14/00
CPC classification number: C07K14/70571 , A61K38/00
Abstract: A variant human alpha 7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human alpha 7 nAChR. Nucleic acid molecules encoding the variant human alpha 7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
Abstract translation: 提供了变体人α7烟碱乙酰胆碱受体（nAChR）多肽，其中变体在野生型人α7nAChR的缬氨酸-274位含有氨基酸取代。 还提供了编码变体人α7nAChR的核酸分子，含有该核酸分子的载体和宿主细胞。 此外，提供了用于产生变体的方法，就是使用这些变体来筛选化合物在nAChR的活性的方法。
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公开(公告)号：EP0970205A2
公开(公告)日：2000-01-12
申请号：EP98901183.8
申请日：1998-01-07
Applicant: Abbott Laboratories
IPC: C12N15/12 , C12N15/70 , C12N15/85 , C12N1/21 , C12N5/10 , C12Q1/02 , C07K14/47 , C07K16/18 , A61K38/17
Abstract: The present invention provides an isolated or purified polynucleotide that encodes human endosulfine polypeptide. Isoforms of human endosulfine are also disclosed. The invention also provides methods of making recombinant human endosulfine using the polynucleotides and host cells transformed with the polynucleotides.
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3.发明公开A VARIANT HUMAN ALPHA-7 ACETYLCHOLINE RECEPTOR SUBUNIT, AND METHODS OF PRODUCTION AND USE THEREOF 失效修饰的人ALPHA 7乙酰胆碱受体亚单位，METHODENZU他们的生产和及其用途
公开(公告)号：EP0946726A2
公开(公告)日：1999-10-06
申请号：EP97954155.0
申请日：1997-12-22
Applicant: Abbott Laboratories
Inventor： BRIGGS, Clark, A. , GOPALAKRISHNAN, Murali , MCKENNA, David, G. , MONTEGGIA, Lisa, M. , ROCH, Jean-Marc , SULLIVAN, James, P. , TOUMA, Edward
CPC classification number: C07K14/70571 , A61K38/00
Abstract: A variant human α7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human α7 nAChR. Nucleic acid molecules encoding the variant human α7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
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