公开(公告)号：WO1998028331A2

公开(公告)日：1998-07-02

申请号：PCT/US1997023405

申请日：1997-12-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BRIGGS, Clark, A. ,  GOPALAKRISHNAN, Murali ,  MCKENNA, David, G. ,  MONTEGGIA, Lisa, M. ,  ROCH, Jean-Marc ,  SULLIVAN, James, P. ,  TOUMA, Edward

IPC: C07K14/00

CPC classification number: C07K14/70571 ,  A61K38/00

Abstract: A variant human alpha 7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human alpha 7 nAChR. Nucleic acid molecules encoding the variant human alpha 7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Abstract translation: 提供了变体人α7烟碱乙酰胆碱受体（nAChR）多肽，其中变体在野生型人α7nAChR的缬氨酸-274位含有氨基酸取代。 还提供了编码变体人α7nAChR的核酸分子，含有该核酸分子的载体和宿主细胞。 此外，提供了用于产生变体的方法，就是使用这些变体来筛选化合物在nAChR的活性的方法。

公开(公告)号：EP0946726A2

公开(公告)日：1999-10-06

申请号：EP97954155.0

申请日：1997-12-22

Applicant: Abbott Laboratories

Inventor： BRIGGS, Clark, A. ,  GOPALAKRISHNAN, Murali ,  MCKENNA, David, G. ,  MONTEGGIA, Lisa, M. ,  ROCH, Jean-Marc ,  SULLIVAN, James, P. ,  TOUMA, Edward

IPC: G01N33 ,  C07K14 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12Q1 ,  A61K38

CPC classification number: C07K14/70571 ,  A61K38/00

Abstract: A variant human α7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human α7 nAChR. Nucleic acid molecules encoding the variant human α7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.