公开(公告)号：WO1995008774A2

公开(公告)日：1995-03-30

申请号：PCT/US1994010850

申请日：1994-09-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CLARK, Frederick, L. ,  CLEMENS, John, M. ,  HANCE, Robert, B. ,  HENDRICK, Kendall, B. ,  TAYI, Apparao ,  KANEWSKE, William, J., III ,  LAGOCKI, Peter, A. ,  MARTIN, Richard, R. ,  McDOWELL, Douglas, D. ,  MERRIAM, Richard, A. ,  MOORE, Larry, W. ,  OLEKSAK, Carl, M. ,  PENNINGTON, Charles, D. ,  RAYMOURE, William, J. ,  RUMBAUGH, William, D. ,  SCHMIDT, Linda, S. ,  SCHRIER, Paul, R. ,  SMITH, B., Jane ,  SPRONK, Adrian, M. ,  WALKER, Edna, S. ,  VAUGHT, James, A. ,  VICKSTROM, Richard, L. ,  WALKER, Donny, Ray ,  WATKINS, William, E., III ,  WINTER, Gary, E.

IPC: G01N35/02

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

Abstract translation: 一种自动化，连续和随机存取分析系统，其具有能够使用不同测定方法同时进行液体样品的多个测定的装置和方法，并且在相同或不同样品的同一或不同样品上进行多个不同测定 时间段被披露。 还公开了一种操作自动化连续和随机存取分析系统的方法，其能够同时进行多个液体样品的多次测定，其中多个液体样品的各种测定的调度之后是产生单位剂量一次性并单独转移 将第一液体样品和试剂加入到反应容器中，而不引发测定反应顺序，随后将单位剂量一次性物理转移到加工工作站，由此在孵育期间实现单位剂量的一次性试剂和样品的混合物。 该系统能够以任何顺序执行多于一次的计划分析，以及提供多于此类计划的测定的测定。 自动，连续和随机存取分析系统还能够通过至少两种测定程序独立地和单独地分析温育的反应混合物。

公开(公告)号：WO1993020450A1

公开(公告)日：1993-10-14

申请号：PCT/US1993002811

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CLARK, Frederic, L. ,  CLIFT, Gilbert ,  HENDRICK, Kendall, B. ,  LAGOCKI, Peter, A. ,  MARTIN, Richard, R. ,  MITCHELL, James, E. ,  MOORE, Larry, W. ,  PENNINGTON, Charles, D. ,  WALKER, Edna, S. ,  SMITH, Jane, B. ,  TAYI, Apparao ,  VAUGHT, James, A. ,  YOST, David, A. ,  KANEWSKE, William, J., III

IPC: G01N35/02

CPC classification number: H01J49/04 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  Y10S435/809 ,  Y10S436/807 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: An automated, continuous and random access analytical system (18), having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system (18) capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26) and reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation (52), whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system (18) is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system (18) is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

Abstract translation: 一种自动化，连续和随机存取分析系统（18），其具有能够使用不同测定方法同时进行液体样品的多个测定的装置和方法，以及在相同或不同样品上进行多个不同测定时提供连续和随机存取 在同一时期内披露。 还公开了一种操作自动连续和随机存取分析系统（18）的方法，其能够同时实现多个液体样品的多次测定，其中多个液体样品的各种测定的调度之后是产生单位剂量一次性和 将第一液体样品（26）和试剂（30）分别转移到反应容器（34）而不引发测定反应顺序，然后将单位剂量的一次性物理转移到处理工作站（52），由此将 在孵育期间实现单位剂量一次性试剂和样品（34）。 系统（18）能够以任何顺序执行多于一个的计划分析，以及多于此类调度测定的测定。 自动化，连续和随机存取分析系统（18）还能够通过至少两种测定程序独立地和单独地分析温育的反应混合物。

公开(公告)号：WO1993020441A1

公开(公告)日：1993-10-14

申请号：PCT/US1993002791

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CLARK, Frederic, L. ,  CLIFT, Gilbert ,  HENDRICK, Kendall, B. ,  KANEWSKE, William, J., III ,  LAGOCKI, Peter, A. ,  MARTIN, Richard, R. ,  MITCHELL, James, E. ,  MOORE, Larry, W. ,  PENNINGTON, Charles, D. ,  WALKER, Edna, S. ,  SMITH, Jane, B. ,  TAYI, Apparao ,  VAUGHT, James, A. ,  YOST, David, A. ,  RUMBAUGH, William ,  WINTER, Gary, E. ,  HANCE, Robert, B. ,  STANTON, Alyn, K. ,  OLEKSAK, Carl, M. ,  WATKINS, William, E., III ,  VICKSTROM, Richard, L. ,  CLOONAN, Kevin, M. ,  WOHLFORD, Robert, A. ,  HILLS, David, B., Jr. ,  SCHRIER, Paul, R.

IPC: G01N33/53

CPC classification number: G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26), reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable (34) to a process work station, whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

Abstract translation: 一种自动化，连续和随机存取分析系统，其具有能够使用不同测定方法同时进行液体样品的多个测定的装置和方法，并且在相同或不同样品的同一或不同样品上进行多个不同测定 时间段被披露。 还公开了一种操作自动化连续和随机存取分析系统的方法，其能够同时进行多个液体样品的多次测定，其中多个液体样品的各种测定的调度之后是产生单位剂量一次性并单独转移 第一液体样品（26），试剂（30）到反应容器（34），而不引发测定反应序列，然后将单位剂量一次性（34）物理转移到处理工作站，由此将单元 剂量一次性试剂和样品（34）在孵育期间实现。 该系统能够以任何顺序执行多于一次的计划分析，以及提供多于此类计划的测定的测定。 自动，连续和随机存取分析系统还能够通过至少两种测定程序独立地和单独地分析温育的反应混合物。

公开(公告)号：WO1993020440A1

公开(公告)日：1993-10-14

申请号：PCT/US1993002644

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CLARK, Frederic, L. ,  CLIFT, Gilbert ,  HENDRICK, Kendall, B. ,  KANEWSKE, William, J., III ,  LAGOCKI, Peter, A. ,  MARTIN, Richard, R. ,  MITCHELL, James, E. ,  MOORE, Larry, W. ,  PENNINGTON, Charles, D. ,  WALKER, Edna, S. ,  SMITH, Jane, B. ,  TAYI, Apparao ,  VAUGHT, James, A. ,  YOST, David, A. ,  MERRIAM, Richard, A. ,  WALKER, Donny, Ray ,  MCDOWELL, Douglas, D. ,  RUMBAUGH, William, A. ,  CLEMENS, John, M.

IPC: G01N33/53

CPC classification number: G01N35/0095 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00277 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, havin apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26), reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable (34) to a process work station (46), whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

Abstract translation: 一种自动化，连续和随机存取分析系统，能够同时使用不同测定方法进行液体样品多重测定的自动化，连续和随机存取分析系统，并且在相同或不同的样品上进行多个不同测定 时间段被披露。 还公开了一种操作自动化连续和随机存取分析系统的方法，其能够同时进行多个液体样品的多次测定，其中多个液体样品的各种测定的调度之后是产生单位剂量一次性并单独转移 第一液体样品（26），试剂（30）到反应容器（34），而不引发测定反应顺序，然后将单位剂量一次性（34）物理转移到处理工作站（46），由此混合 的单位剂量一次性试剂和样品（34）在孵育期间实现。 该系统能够以任何顺序执行多于一次的计划分析，以及提供多于此类计划的测定的测定。 自动，连续和随机存取分析系统还能够通过至少两种测定程序独立地和单独地分析温育的反应混合物。

公开(公告)号：WO1993020444A1

公开(公告)日：1993-10-14

申请号：PCT/US1993002776

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  RAYMOURE, William, J. ,  CLARK, Frederic, L. ,  CLIFT, Gilbert ,  HENDRICK, Kendall, B. ,  KANEWSKE, William, J., III ,  LAGOCKI, Peter, A. ,  MARTIN, Richard, R. ,  MITCHELL, James, E. ,  MOORE, Larry, E. ,  PENNINGTON, Charles, D. ,  WALKER, Edna, S. ,  SMITH, Jane, B. ,  TAYI, Apparao ,  VAUGHT, James, A. ,  YOST, David, A.

IPC: G01N33/546

CPC classification number: B01L3/50853 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A method for modifying a liquid assay reagent to provide prolonged homogeneity thereof, particularly where the liquid assay reagent comprises microparticles for performing a heterogeneous immunoassay, is provided wherein the addition of an inert material to a liquid assay reagent achieves neutral density to thereby prolong the homogeneity thereof for extended periods of time. A method for the automated agitation of assay reagents to maintain the homogeneity thereof with an automated, continuous and random access analytical instrument is also provided. The automated mixing is accomplished by a back and forth motion of a carousel onto which assay reagent containers or packs are mounted with asymmetric pauses which can be completed within a short period of time. The carousel acceleration, velocity, distance moved, and pause-asymmetry are optimized to provide rapid assay reagent resuspension without foaming or bubble formation. Accordingly, periodic removal of assay reagent packs by an operator in order to mix the reagents is not necessary.

Abstract translation: 提供一种用于改变液体测定试剂以提供其延长的均匀性的方法，特别是在液体测定试剂包含用于进行非均相免疫测定的微粒的情况下，其中向液体测定试剂中加入惰性物质达到中性密度从而延长均匀性 延长时间。 还提供了一种用于自动搅拌测定试剂以保持其与自动化，连续和随机存取分析仪器的同质性的方法。 自动化混合是通过旋转木马的来回运动完成的，在该转盘上，分析试剂容器或包装件以不对称的停顿方式安装在该转盘上，可以在短时间内完成。 旋转木马加速度，速度，移动距离和暂停不对称性被优化，以提供快速的测定试剂重悬浮而没有起泡或气泡形成。 因此，为了混合试剂，由操作者定期去除测定试剂包是不必要的。

公开(公告)号：WO1993020443A1

公开(公告)日：1993-10-14

申请号：PCT/US1993002777

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SCHMIDT, Linda, S. ,  SPRONK, Adrian, M. ,  CLARK, Frederic, L. ,  CLIFT, Gilbert ,  HENDRICK, Kendall, B. ,  KANEWSKE, William, J., III ,  LAGOCKI, Peter, A. ,  MITCHELL, James, E. ,  MARTIN, Richard, R. ,  MOORE, Larry, E. ,  PENNINGTON, Charles, D. ,  WALKER, Edna, S. ,  SMITH, Jane, B. ,  TAYI, Apparao ,  VAUGHT, James, A. ,  YOST, David, A.

IPC: G01N33/543

CPC classification number: B01L3/50853 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/025 ,  G01N2001/007 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0453 ,  G01N2035/1025 ,  H01J49/04

Abstract: A method for verifying that an assay methodology is properly performed that assay reagents employed possess the necessary potency for accurately performing such assay methodology, and whether or not test samples or assay reagents have been tampered with or are adulterated, is described. The method is performed by employing an assay verification sample, comprising a positive analyte component and the test sample under analysis, wherein the assay verification sample is analyzed employing the same assay reagents and essentially the same assay methodology employed to analyze the test sample. The method is particularly useful for performing heterogeneous immunoassays on an automated continuous and random access analytical system.

Abstract translation: 描述了用于验证测定方法学的方法，所用测定试剂具有用于准确地进行这种测定方法学以及测试样品或测定试剂是否被篡改或掺杂的必要效力。 该方法通过采用包含正分析物组分和待分析的测试样品的测定验证样品进行，其中使用相同的测定试剂和用于分析测试样品的基本相同的测定方法分析测定验证样品。 该方法对于在自动连续和随机存取分析系统上进行异质免疫测定特别有用。

公开(公告)号：WO1993019928A1

公开(公告)日：1993-10-14

申请号：PCT/US1993002790

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KANEWSKE, William, J., III ,  VAUGHT, James, A. ,  VICKSTROM, Richard, L. ,  CLARK, Frederic, L. ,  CLIFT, Gilbert ,  HENDRICK, Kendall, B. ,  LAGOCKI, Peter, A. ,  MARTIN, Richard, E. ,  MITCHELL, James, E. ,  MOORE, Larry, E. ,  PENNINGTON, Charles, D. ,  WALKER, Edna, S. ,  SMITH, Jane, B. ,  TAYI, Apparao ,  YOST, David, A.

IPC: B29D23/22

CPC classification number: B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A plastic assay cuvette (506) having the desired optical properties for the analysis of a test sample or reaction mixture thereof, and a method for making such a plastic assay cuvette (506), are described. The optical properties of the plastic assay cuvette (506) are substantially the same as the optical properties of glass wherein low birefringence throughout the optical read region (516) thereof is provided. When used for the analysis of a test sample or reaction mixture thereof, such as in fluorescence polarization assays and absorbance assays, the plastic assay cuvette (506) provides accurate and reproducible disposable assay cuvette which can be used in place of conventional glass assay cuvettes.

Abstract translation: 描述了具有用于分析测试样品或其反应混合物的所需光学性质的塑料分析试管（506）以及制备这种塑料分析试管（506）的方法。 塑料分析试管（506）的光学性质与玻璃的光学性质基本相同，其玻璃的光学读取区域（516）的双折射率低。 当用于分析测试样品或其反应混合物时，例如在荧光偏振测定和吸光度测定中，塑料分析比色皿（506）提供可用于代替常规玻璃分析比色皿的精确和可重现的一次性分析比色皿。

公开(公告)号：EP0637283A1

公开(公告)日：1995-02-08

申请号：EP93908570.0

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： KANEWSKE, William, J., III ,  VAUGHT, James, A. ,  VICKSTROM, Richard, L. ,  CLARK, Frederic, L. ,  CLIFT, Gilbert ,  HENDRICK, Kendall, B. ,  LAGOCKI, Peter, A. ,  MARTIN, Richard, E. ,  MITCHELL, James, E. ,  MOORE, Larry, E. ,  PENNINGTON, Charles, D. ,  WALKER, Edna, S. ,  SMITH, Jane, B. ,  TAYI, Apparao ,  YOST, David, A.

IPC: B01L3 ,  B29C45 ,  B29D11 ,  B29D23 ,  G01N21 ,  G01N33 ,  G01N35 ,  H01J49 ,  B01L9 ,  G01N1

CPC classification number: B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A plastic assay cuvette (506) having the desired optical properties for the analysis of a test sample or reaction mixture thereof, and a method for making such a plastic assay cuvette (506), are described. The optical properties of the plastic assay cuvette (506) are substantially the same as the optical properties of glass wherein low birefringence throughout the optical read region (516) thereof is provided. When used for the analysis of a test sample or reaction mixture thereof, such as in fluorescence polarization assays and absorbance assays, the plastic assay cuvette (506) provides accurate and reproducible disposable assay cuvette which can be used in place of conventional glass assay cuvettes.

公开(公告)号：EP0720747B1

公开(公告)日：2002-07-17

申请号：EP94929339.3

申请日：1994-09-22

Applicant: ABBOTT LABORATORIES

Inventor： CLARK, Frederick L. ,  CLEMENS, John M. ,  HANCE, Robert B. ,  HENDRICK, Kendall B. ,  TAYI, Apparao ,  KANEWSKE, William J., III ,  LAGOCKI, Peter A. ,  MARTIN, Richard R. ,  McDOWELL, Douglas D. ,  MERRIAM, Richard A. ,  MOORE, Larry W. ,  OLEKSAK, Carl M. ,  PENNINGTON, Charles D. ,  RAYMOURE, William J. ,  RUMBAUGH, William D. ,  SCHMIDT, Linda S. ,  SCHRIER, Paul R. ,  SMITH, B.Jane ,  SPRONK, Adrian M. ,  WALKER, Edna S. ,  VAUGHT, James A. ,  VICKSTROM, Richard L. ,  WALKER, Donny Ray ,  WATKINS, William E., III ,  WINTER, Gary E. ,  WOHLFORD, Robert A. ,  CLIFT, Gilbert ,  CLOONAN, Kevin M. ,  MITCHELL, James E. ,  STANTON, Alyn K. ,  YOST, David A. ,  HILLS, David B.

IPC: G01N35/02

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：EP0746769A1

公开(公告)日：1996-12-11

申请号：EP93908571.0

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： CLARK, Frederic, L. ,  CLIFT, Gilbert ,  HENDRICK, Kendall, B. ,  KANEWSKE, William, J., III ,  LAGOCKI, Peter, A. ,  MARTIN, Richard, R. ,  MITCHELL, James, E. ,  MOORE, Larry, W. ,  PENNINGTON, Charles, D. ,  WALKER, Edna, S. ,  SMITH, Jane, B. ,  TAYI, Apparao ,  VAUGHT, James, A. ,  YOST, David, A. ,  RUMBAUGH, William ,  WINTER, Gary, E. ,  HANCE, Robert, B. ,  STANTON, Alyn, K. ,  OLEKSAK, Carl, M. ,  WATKINS, William, E., III ,  VICKSTROM, Richard, L. ,  CLOONAN, Kevin, M. ,  WOHLFORD, Robert, A. ,  HILLS, David, B., Jr. ,  SCHRIER, Paul, R.

IPC: B01L3 ,  G01N1 ,  G01N21 ,  G01N33 ,  G01N35 ,  G05D23 ,  H01J49 ,  H02P8 ,  H05B41 ,  B01L9

CPC classification number: G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26), reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable (34) to a process work station, whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.