公开(公告)号：EP0720747B1

公开(公告)日：2002-07-17

申请号：EP94929339.3

申请日：1994-09-22

Applicant: ABBOTT LABORATORIES

Inventor： CLARK, Frederick L. ,  CLEMENS, John M. ,  HANCE, Robert B. ,  HENDRICK, Kendall B. ,  TAYI, Apparao ,  KANEWSKE, William J., III ,  LAGOCKI, Peter A. ,  MARTIN, Richard R. ,  McDOWELL, Douglas D. ,  MERRIAM, Richard A. ,  MOORE, Larry W. ,  OLEKSAK, Carl M. ,  PENNINGTON, Charles D. ,  RAYMOURE, William J. ,  RUMBAUGH, William D. ,  SCHMIDT, Linda S. ,  SCHRIER, Paul R. ,  SMITH, B.Jane ,  SPRONK, Adrian M. ,  WALKER, Edna S. ,  VAUGHT, James A. ,  VICKSTROM, Richard L. ,  WALKER, Donny Ray ,  WATKINS, William E., III ,  WINTER, Gary E. ,  WOHLFORD, Robert A. ,  CLIFT, Gilbert ,  CLOONAN, Kevin M. ,  MITCHELL, James E. ,  STANTON, Alyn K. ,  YOST, David A. ,  HILLS, David B.

IPC: G01N35/02

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：EP0755519A1

公开(公告)日：1997-01-29

申请号：EP93908481.0

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： CLARK, Frederic L. ,  CLIFT, Gilbert ,  HENDRICK, Kendall B. ,  KANEWSKE, William J., III ,  LAGOCKI, Peter A. ,  MARTIN, Richard R. ,  MITCHELL, James E. ,  MOORE, Larry W. ,  PENNINGTON, Charles D. ,  WALKER, Edna S. ,  SMITH, Jane B. ,  TAYI, Apparao ,  VAUGHT, James A. ,  YOST, David A. ,  MERRIAM, Richard A. ,  WALKER, Donny Ray ,  MCDOWELL, Douglas D. ,  RUMBAUGH, William A. ,  CLEMENS, John M.

IPC: B01L3 ,  B29C45 ,  B67D99 ,  C12M1 ,  G01F23 ,  G01N1 ,  G01N21 ,  G01N33 ,  G01N35 ,  G05D23 ,  H01J49 ,  H05B1 ,  B01L9

CPC classification number: G01N35/0095 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00277 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, havin apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26), reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable (34) to a process work station (46), whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：EP0755519B1

公开(公告)日：2003-10-01

申请号：EP93908481.0

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： CLARK, Frederic L. ,  CLIFT, Gilbert ,  HENDRICK, Kendall B. ,  KANEWSKE, William J., III ,  LAGOCKI, Peter A. ,  MARTIN, Richard R. ,  MITCHELL, James E. ,  MOORE, Larry W. ,  PENNINGTON, Charles D. ,  WALKER, Edna S. ,  SMITH, Jane B. ,  TAYI, Apparao ,  VAUGHT, James A. ,  YOST, David A. ,  MERRIAM, Richard A. ,  WALKER, Donny Ray ,  MCDOWELL, Douglas D. ,  RUMBAUGH, William A. ,  CLEMENS, John M.

IPC: G01N35/02

CPC classification number: G01N35/0095 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00277 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, havin apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26), reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable (34) to a process work station (46), whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：EP0634016B1

公开(公告)日：2001-09-19

申请号：EP93908561.9

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： SCHMIDT, Linda S. ,  SPRONK, Adrian M. ,  CLARK, Frederic L. ,  CLIFT, Gilbert ,  HENDRICK, Kendall B. ,  KANEWSKE, William J., III ,  LAGOCKI, Peter A. ,  MITCHELL, James E. ,  MARTIN, Richard R. ,  MOORE, Larry E. ,  PENNINGTON, Charles D. ,  WALKER, Edna S. ,  SMITH, Jane B. ,  TAYI, Apparao ,  VAUGHT, James A. ,  YOST, David A.

IPC: G01N33/543 ,  G01N35/02 ,  G01N33/483 ,  G01N33/538 ,  G01N33/53 ,  G01N33/02

CPC classification number: B01L3/50853 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/025 ,  G01N2001/007 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0453 ,  G01N2035/1025 ,  H01J49/04

Abstract: A method for verifying that an assay methodology is properly performed that assay reagents employed possess the necessary potency for accurately performing such assay methodology, and whether or not test samples or assay reagents have been tampered with or are adulterated, is described. The method is performed by employing an assay verification sample, comprising a positive analyte component and the test sample under analysis, wherein the assay verification sample is analyzed employing the same assay reagents and essentially the same assay methodology employed to analyze the test sample. The method is particularly useful for performing heterogeneous immunoassays on an automated continuous and random access analytical system.

公开(公告)号：EP0720747A1

公开(公告)日：1996-07-10

申请号：EP94929339.0

申请日：1994-09-22

Applicant: ABBOTT LABORATORIES

Inventor： CLARK, Frederick L. ,  CLEMENS, John M. ,  HANCE, Robert B. ,  HENDRICK, Kendall B. ,  TAYI, Apparao ,  KANEWSKE, William J., III ,  LAGOCKI, Peter A. ,  MARTIN, Richard R. ,  McDOWELL, Douglas D. ,  MERRIAM, Richard A. ,  MOORE, Larry W. ,  OLEKSAK, Carl M. ,  PENNINGTON, Charles D. ,  RAYMOURE, William J. ,  RUMBAUGH, William D. ,  SCHMIDT, Linda S. ,  SCHRIER, Paul R. ,  SMITH, B.Jane ,  SPRONK, Adrian M. ,  WALKER, Edna S. ,  VAUGHT, James A. ,  VICKSTROM, Richard L. ,  WALKER, Donny Ray ,  WATKINS, William E., III ,  WINTER, Gary E. ,  WOHLFORD, Robert A. ,  CLIFT, Gilbert ,  CLOONAN, Kevin M. ,  MITCHELL, James E. ,  STANTON, Alyn K. ,  YOST, David A. ,  HILLS, David B.

IPC: G01N33 ,  B01F11 ,  B01L3 ,  B29C45 ,  G01F23 ,  G01N21 ,  G01N35 ,  H01J49 ,  G01N1

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：EP0634016A1

公开(公告)日：1995-01-18

申请号：EP93908561.0

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： SCHMIDT, Linda S. ,  SPRONK, Adrian M. ,  CLARK, Frederic L. ,  CLIFT, Gilbert ,  HENDRICK, Kendall B. ,  KANEWSKE, William J., III ,  LAGOCKI, Peter A. ,  MITCHELL, James E. ,  MARTIN, Richard R. ,  MOORE, Larry E. ,  PENNINGTON, Charles D. ,  WALKER, Edna S. ,  SMITH, Jane B. ,  TAYI, Apparao ,  VAUGHT, James A. ,  YOST, David A.

IPC: B01L3 ,  G01N21 ,  G01N33 ,  G01N35 ,  H01J49 ,  B01L9 ,  G01N1

CPC classification number: B01L3/50853 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/025 ,  G01N2001/007 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0453 ,  G01N2035/1025 ,  H01J49/04

Abstract: A method for verifying that an assay methodology is properly performed that assay reagents employed possess the necessary potency for accurately performing such assay methodology, and whether or not test samples or assay reagents have been tampered with or are adulterated, is described. The method is performed by employing an assay verification sample, comprising a positive analyte component and the test sample under analysis, wherein the assay verification sample is analyzed employing the same assay reagents and essentially the same assay methodology employed to analyze the test sample. The method is particularly useful for performing heterogeneous immunoassays on an automated continuous and random access analytical system.