公开(公告)号：WO2012161812A1

公开(公告)日：2012-11-29

申请号：PCT/US2012/026685

申请日：2012-02-27

Applicant: ABBOTT LABORATORIES ,  TONG, Yunsong ,  PENNING, Thomas, D. ,  FLORJANCIC, Alan ,  MIYASHIRO, Julie ,  WOODS, Keith W.

Inventor： TONG, Yunsong ,  PENNING, Thomas, D. ,  FLORJANCIC, Alan ,  MIYASHIRO, Julie ,  WOODS, Keith W.

IPC: C07D487/14 ,  A61K31/4375 ,  A61P35/00

CPC classification number: C07D487/14

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, ( l ) wherein X, Y, Z, R 3 and R 4 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，（I）其中X，Y，Z，R 3和R 4在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：WO2007140233A1

公开(公告)日：2007-12-06

申请号：PCT/US2007/069630

申请日：2007-05-24

Applicant: ABBOTT LABORATORIES ,  DIEBOLD, Robert B. ,  DJURIC, Stevan W. ,  GIRANDA, Vincent L ,  HEXAMER, Laura ,  LIN, Nan-horng ,  MIYASHIRO, Julie M. ,  PENNING, Thomas D. ,  PRZYTULINSKA, Magdalena ,  SOWIN, Thomas ,  SULLIVAN, Gerard ,  TAO, Zhi-fu ,  TONG, Yunsong ,  VASUDEVAN, Anil ,  WANG, Le ,  WOODS, Keith W. ,  XIA, Zhiren ,  ZHANG, Henry Q.

Inventor： DIEBOLD, Robert B. ,  DJURIC, Stevan W. ,  GIRANDA, Vincent L ,  HEXAMER, Laura ,  LIN, Nan-horng ,  MIYASHIRO, Julie M. ,  PENNING, Thomas D. ,  PRZYTULINSKA, Magdalena ,  SOWIN, Thomas ,  SULLIVAN, Gerard ,  TAO, Zhi-fu ,  TONG, Yunsong ,  VASUDEVAN, Anil ,  WANG, Le ,  WOODS, Keith W. ,  XIA, Zhiren ,  ZHANG, Henry Q.

IPC: C07C225/20 ,  C07D249/14 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20 ,  A61P35/00 ,  A61K31/132 ,  A61K31/505

CPC classification number: C07D249/14 ,  C07C225/20 ,  C07C2601/02 ,  C07C2601/04 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20

Abstract: Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

Abstract translation: 公开了抑制Plk1的化合物，含有该化合物的组合物和使用该化合物治疗疾病的方法。

公开(公告)号：WO2011008915A1

公开(公告)日：2011-01-20

申请号：PCT/US2010/042067

申请日：2010-07-15

Applicant: ABBOTT LABORATORIES ,  FLORJANCIC, Alan ,  TONG, Yunsong ,  PENNING, Thomas

Inventor： FLORJANCIC, Alan ,  TONG, Yunsong ,  PENNING, Thomas

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, formula (I) wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，式（I）其中R 1a，R 1b，R 1c，X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：WO2011008830A1

公开(公告)日：2011-01-20

申请号：PCT/US2010/041935

申请日：2010-07-14

Applicant: ABBOTT LABORATORIES ,  PENNING, Thomas, D. ,  GANDHI, Viraj, B. ,  ZHU, Guidong ,  TONG, Yunsong ,  WOODS, Keith, W. ,  LAI, Chunqiu ,  GONG, Jane ,  FLORJANCIC, Alan, S.

Inventor： PENNING, Thomas, D. ,  GANDHI, Viraj, B. ,  ZHU, Guidong ,  TONG, Yunsong ,  WOODS, Keith, W. ,  LAI, Chunqiu ,  GONG, Jane ,  FLORJANCIC, Alan, S.

IPC: C07D487/04 ,  A61K317/519 ,  A61P35/00

CPC classification number: C07D487/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R 1a , R 1b , X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：WO2005047294A1

公开(公告)日：2005-05-26

申请号：PCT/US2004/036582

申请日：2004-11-03

Applicant: ABBOTT LABORATORIES ,  TAO, Zhi-Fu ,  LIN, Nan-Horng ,  WANG, Le ,  SOWIN, Thomas, J. ,  SULLIVAN, Gerard M. ,  TONG, Yunsong ,  PRZYTULINSKA, Magdalenna ,  LI, Gaoquan

Inventor： TAO, Zhi-Fu ,  LIN, Nan-Horng ,  WANG, Le ,  SOWIN, Thomas, J. ,  SULLIVAN, Gerard M. ,  TONG, Yunsong ,  PRZYTULINSKA, Magdalenna ,  LI, Gaoquan

IPC: C07D498/08

CPC classification number: C07D498/08 ,  C07D498/18

Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds

Abstract translation: 具有式（I）的化合物可用于抑制蛋白激酶。 还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法

公开(公告)号：WO2002074747A1

公开(公告)日：2002-09-26

申请号：PCT/US2001/043168

申请日：2001-11-30

Applicant: ABBOTT LABORATORIES

Inventor： CLAIBORNE, Akiyo, K. ,  GWALTNEY, Stephen, L, II ,  HASVOLD, Lisa, A. ,  LI, Qun ,  LI, Tomgmei ,  LIN, Nan-Horng ,  MANTEI, Robert, A. ,  ROCKWAY, Todd, W. ,  SHAM, Hing, L. ,  SULLIVAN, Gerard, M. ,  TONG, Yunsong ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WANG, Weibo

IPC: C07D233/64

CPC classification number: C07D233/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having formula (I), are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

Abstract translation: 具有式（I）的取代的咪唑和噻唑可用于抑制法呢基转移酶。 还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。

公开(公告)号：WO2010083220A1

公开(公告)日：2010-07-22

申请号：PCT/US2010/020903

申请日：2010-01-13

Applicant: ABBOTT LABORATORIES ,  TONG, Yunsong ,  PENNING, Thomas, D. ,  PRZYTULINSKA, Magdalena

Inventor： TONG, Yunsong ,  PENNING, Thomas, D. ,  PRZYTULINSKA, Magdalena

IPC: C07D263/58 ,  C07D413/04 ,  C07D413/10 ,  C07D263/57 ,  A61K31/423 ,  A61P35/04 ,  A61P29/00 ,  A61P25/16

CPC classification number: C07D413/04 ,  C07D263/57 ,  C07D263/58 ,  C07D413/10

Abstract: Inhibitors of poly(ADP-ribose)polymerase having a structure of Formula (I), ways to make them and methods of treating patients using them are disclosed.

Abstract translation: 公开了具有式（I）结构的聚（ADP-核糖）聚合酶的抑制剂，其制备方法和使用它们治疗患者的方法。

公开(公告)号：WO2010083199A1

公开(公告)日：2010-07-22

申请号：PCT/US2010/020878

申请日：2010-01-13

Applicant: ABBOTT LABORATORIES ,  PRZYTULINSKA, Magdalena, K. ,  PENNING, Thomas, D. ,  TONG, Yunsong

Inventor： PRZYTULINSKA, Magdalena, K. ,  PENNING, Thomas, D. ,  TONG, Yunsong

IPC: C07D417/04 ,  C07D417/10 ,  A61K31/428 ,  A61K31/4409 ,  A61P35/04

CPC classification number: C07D417/04 ,  C07D417/10

Abstract: Inhibitors of poly(ADP-ribose)polymerase having a structure of Formula (I), ways to make them and methods of treating patients using them are disclosed.

Abstract translation: 公开了具有式（I）结构的聚（ADP-核糖）聚合酶的抑制剂，其制备方法和使用它们治疗患者的方法。

公开(公告)号：EP1339695A1

公开(公告)日：2003-09-03

申请号：EP01273519.7

申请日：2001-11-30

Applicant: Abbott Laboratories

Inventor： CLAIBORNE, Akiyo, K. ,  GWALTNEY, Stephen, L, II ,  HASVOLD, Lisa, A. ,  LI, Qun ,  LI, Tomgmei ,  LIN, Nan-Horng ,  MANTEI, Robert, A. ,  ROCKWAY, Todd, W. ,  SHAM, Hing, L. ,  SULLIVAN, Gerard, M. ,  TONG, Yunsong ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WANG, Weibo

IPC: C07D233/64 ,  A61K31/4164 ,  C07D401/12 ,  A61P35/00

CPC classification number: C07D233/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：EP2454257A1

公开(公告)日：2012-05-23

申请号：EP10749531.9

申请日：2010-07-15

Applicant: Abbott Laboratories

Inventor： FLORJANCIC, Alan ,  TONG, Yunsong ,  PENNING, Thomas

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, formula (I) wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.