公开(公告)号：WO2008131000A2

公开(公告)日：2008-10-30

申请号：PCT/US2008/060472

申请日：2008-04-16

Applicant: ABBOTT LABORATORIES ,  ELMORE, Steven, W. ,  SOUERS, Andrew, J. ,  BRUNCKO, Milan ,  SONG, Xiaohong ,  WANG, Xilu ,  HASVOLD, Lisa, A. ,  WANG, Le ,  KUNZER, Aaron, R. ,  PARK, Cheol-min ,  WENDT, Michael, D. ,  TAO, Zhi-fu

Inventor： ELMORE, Steven, W. ,  SOUERS, Andrew, J. ,  BRUNCKO, Milan ,  SONG, Xiaohong ,  WANG, Xilu ,  HASVOLD, Lisa, A. ,  WANG, Le ,  KUNZER, Aaron, R. ,  PARK, Cheol-min ,  WENDT, Michael, D. ,  TAO, Zhi-fu

IPC: C07D209/34 ,  C07D401/12 ,  C07D413/06 ,  C07D417/04 ,  A61P35/00 ,  A61K31/404

CPC classification number: C07D209/42 ,  A61K31/5377 ,  C07D209/34 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D491/113

Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.

Abstract translation: 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。

公开(公告)号：WO2007040650A2

公开(公告)日：2007-04-12

申请号：PCT/US2006/018799

申请日：2006-05-12

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DING, Hong ,  ELMORE, Steven, W. ,  KUNZER, Aaron, R. ,  LYNCH, Christopher, L. ,  MCCELLAN, William, J. ,  PARK, Cheol Min ,  SONG, Xiahong ,  WANG, Xilu

Inventor： BRUNCKO, Milan ,  DING, Hong ,  ELMORE, Steven, W. ,  KUNZER, Aaron, R. ,  LYNCH, Christopher, L. ,  MCCELLAN, William, J. ,  PARK, Cheol Min ,  SONG, Xiahong ,  WANG, Xilu

IPC: C07D295/14 ,  C07D487/08 ,  C07D491/08 ,  A61K31/496

CPC classification number: C07D295/155 ,  C07D487/08 ,  C07D491/08

Abstract: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti?apoptotic family protein member are disclosed.

Abstract translation: 公开了抑制抗凋亡家族蛋白成员活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中发生表达一种或多种抗凋亡家族蛋白成员。

公开(公告)号：WO2002074747A1

公开(公告)日：2002-09-26

申请号：PCT/US2001/043168

申请日：2001-11-30

Applicant: ABBOTT LABORATORIES

Inventor： CLAIBORNE, Akiyo, K. ,  GWALTNEY, Stephen, L, II ,  HASVOLD, Lisa, A. ,  LI, Qun ,  LI, Tomgmei ,  LIN, Nan-Horng ,  MANTEI, Robert, A. ,  ROCKWAY, Todd, W. ,  SHAM, Hing, L. ,  SULLIVAN, Gerard, M. ,  TONG, Yunsong ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WANG, Weibo

IPC: C07D233/64

CPC classification number: C07D233/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having formula (I), are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

Abstract translation: 具有式（I）的取代的咪唑和噻唑可用于抑制法呢基转移酶。 还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。

公开(公告)号：WO2011068560A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/036844

申请日：2010-06-01

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert A. ,  McCLELLAN, William J. ,  PARK, Chang H. ,  PARK, Cheol-Min ,  PETROS, Andrew M. ,  SONG, Xiaohong ,  SOUERS, Andrew J. ,  SULLIVAN, Gerard M. ,  TAO, Zhi-Fu ,  WANG, Gary T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael D. ,  HANSEN, Todd M.

Inventor： BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert A. ,  McCLELLAN, William J. ,  PARK, Chang H. ,  PARK, Cheol-Min ,  PETROS, Andrew M. ,  SONG, Xiaohong ,  SOUERS, Andrew J. ,  SULLIVAN, Gerard M. ,  TAO, Zhi-Fu ,  WANG, Gary T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael D. ,  HANSEN, Todd M.

IPC: C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D309/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

CPC classification number: C07D209/08 ,  A61K31/635 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D309/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：WO2010065865A2

公开(公告)日：2010-06-10

申请号：PCT/US2009/066790

申请日：2009-12-04

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

Inventor： BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

IPC: C07D405/12 ,  A61K31/404 ,  A61P35/00

CPC classification number: C07D405/12 ,  C07D209/32 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D309/14 ,  C07D401/12 ,  C07D417/12

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。

公开(公告)号：WO2010065824A2

公开(公告)日：2010-06-10

申请号：PCT/US2009/066722

申请日：2009-12-04

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

Inventor： BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

IPC: A61P35/00 ,  A61K31/496 ,  C07D403/12

CPC classification number: C07D405/12 ,  C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。

公开(公告)号：WO2011150016A1

公开(公告)日：2011-12-01

申请号：PCT/US2011/037849

申请日：2011-05-25

Applicant: ABBOTT LABORATORIES ,  TAO, Zhi-Fu ,  WANG, Xilu ,  SOUERS, Andrew J. ,  CATRON, Nathaniel D. ,  SULLIVAN, Gerard

Inventor： TAO, Zhi-Fu ,  WANG, Xilu ,  SOUERS, Andrew J. ,  CATRON, Nathaniel D. ,  SULLIVAN, Gerard

IPC: A01N43/42 ,  A01N43/40 ,  A61K31/44 ,  A01N43/38

CPC classification number: C07D471/04 ,  A61K31/18 ,  A61K31/44 ,  A61K31/496 ,  A61P35/00 ,  C07F9/65616 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/411 ,  Y02A50/463

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：WO2011149492A1

公开(公告)日：2011-12-01

申请号：PCT/US2010/057587

申请日：2010-11-22

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George ,  ELMORE, Steven ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron R. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael ,  MANTEI, Robert ,  HANSEN, Todd, M.

Inventor： BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George ,  ELMORE, Steven ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron R. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael ,  MANTEI, Robert ,  HANSEN, Todd, M.

IPC: C07D471/04 ,  A61K31/437 ,  A61K35/00

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D209/82 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/463

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：WO2006127364A1

公开(公告)日：2006-11-30

申请号：PCT/US2006/019132

申请日：2006-05-17

Applicant: ABBOTT LABORATORIES ,  ELMORE, Steven ,  LYNCH, Christopher ,  WANG, Xilu

Inventor： ELMORE, Steven ,  LYNCH, Christopher ,  WANG, Xilu

IPC: C07D273/00 ,  C07D413/12 ,  A61K31/395 ,  A61P35/00

CPC classification number: C07D273/02 ,  C07D273/00 ,  C07D413/12

Abstract: Compounds of formula (I), in which B 1 and X 1 are together alkylene which is unsubstituted or substituted with =O and having one CH2 moiety unreplaced or replaced with CH=CH, O, NH or N(alkyl), which inhibit the activity of antiapoptotic Bcl-2 family protein members, compositions containing the compounds and methods of treating diseases during which are expressed one or more than one of an anti-apoptotic family protein member are disclosed.

Abstract translation: 其中B 1和X 2的式（I）化合物在一起是未被取代或被= O取代且具有一个CH2部分的亚烷基未置换或被CH = CH，O，NH或N（烷基），其抑制抗凋亡Bcl-2家族蛋白成员的活性，含有该化合物的组合物和治疗疾病的方法，其中表达一种或多种抗凋亡家族蛋白成员 被披露。

公开(公告)号：WO2005049593A2

公开(公告)日：2005-06-02

申请号：PCT/US2004/036770

申请日：2004-11-03

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  ELMORE, Steven ,  KUNZER, Aaron, R. ,  LYNCH, Christopher, L. ,  WANG, Xilu ,  WENDT, Michael, D.

Inventor： BRUNCKO, Milan ,  ELMORE, Steven ,  KUNZER, Aaron, R. ,  LYNCH, Christopher, L. ,  WANG, Xilu ,  WENDT, Michael, D.

IPC: C07D295/14

CPC classification number: C07D277/74 ,  C04B35/632 ,  C07C323/25 ,  C07C2601/16 ,  C07D205/04 ,  C07D207/16 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D295/13 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D409/12 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which are expressed one or more than one of an anti apoptotic protein family member.

Abstract translation: 公开了抑制抗凋亡蛋白质家族成员的活性的化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，在该疾病期间表达一种或多种抗 - 凋亡蛋白家族成员。