公开(公告)号：WO2015073515A1

公开(公告)日：2015-05-21

申请号：PCT/US2014/065182

申请日：2014-11-12

Applicant: ABBOTT LABORATORIES

Inventor： VAZHAPPILLY, Rema ,  LAI, Chron-Si ,  KUCHAN, Matthew

IPC: A61K31/355 ,  A61K31/20 ,  A61P11/00 ,  A61P25/00

CPC classification number: A61K31/355 ,  A23L33/10 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/047 ,  A61K31/20 ,  A61K31/202

Abstract: Disclosed herein are nutritional compositions for pregnant or lactating mothers, pre-term and term infants, toddlers and children which include natural vitamin E, a long chain polyunsaturated fatty acid (LC-PUFA) and a cartenoid such as lutein. Also disclosed are methods of administering these compositions for reducing or preventing the susceptibility of the fetal and newborn brain and lungs to hypoxia and the resulting disorders resulting therefrom including abnormal cognitive development, brain injury and lung injury.

Abstract translation: 本文公开了含有天然维生素E，长链多不饱和脂肪酸（LC-PUFA）和诸如叶黄素的电解质的怀孕或哺乳期母亲，早产儿和术前婴儿，幼儿和儿童的营养组合物。 还公开了施用这些组合物以减少或预防胎儿和新生儿脑和肺对缺氧的易感性的方法，以及由此产生的所得病症包括异常的认知发育，脑损伤和肺损伤。

公开(公告)号：WO2014047614A1

公开(公告)日：2014-03-27

申请号：PCT/US2013/061343

申请日：2013-09-24

Applicant: ABBOTT LABORATORIES

Inventor： VAZHAPPILLY, Rema ,  HAHN, Isabela Balassiano ,  DAS, Tapas ,  GELLING, Richard Wayne

IPC: A23L1/30 ,  A61K31/685 ,  A61K31/202 ,  A61K36/80

CPC classification number: A61K31/685 ,  A23L33/10 ,  A23L33/105 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/202 ,  A61K36/80 ,  A23V2200/322 ,  A23V2250/0612 ,  A23V2250/156 ,  A23V2250/1842 ,  A23V2250/1852 ,  A23V2250/1868 ,  A23V2250/21 ,  A23V2250/211 ,  A23V2250/5424 ,  A23V2250/628 ,  A23V2250/702 ,  A23V2250/704 ,  A23V2250/708 ,  A23V2250/71 ,  A23V2250/712 ,  A61K2300/00

Abstract: Methods and nutritional compositions for improving or enhancing cognitive function, muscle function, or both in a subject are provided. The nutritional compositions comprise a combination of Bacopa and phosphatidylserine-docosahexaenoic acid complex.

Abstract translation: 提供了用于改善或增强受试者的认知功能，肌肉功能或两者的方法和营养组合物。 营养组合物包含Bacopa和磷脂酰丝氨酸 - 二十二碳六烯酸复合物的组合。

公开(公告)号：WO2014200961A1

公开(公告)日：2014-12-18

申请号：PCT/US2014/041630

申请日：2014-06-10

Applicant: ABBOTT LABORATORIES

Inventor： VAZHAPPILLY, Rema ,  DAS, Tapas

IPC: A61K31/14 ,  A61K31/201 ,  A61K31/661 ,  A61P25/28

CPC classification number: A61K31/685 ,  A23L33/105 ,  A23L33/115 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/0095 ,  A61K31/14 ,  A61K31/201 ,  A61K31/661 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2250/1846 ,  A23V2250/1852 ,  A23V2250/188

Abstract: Compositions including an effective amount of each of phosphatidyl serine, choline, and oleic acid, and methods for improving cognitive performance that include administering such compositions to a subject, are described herein. The compositions can be nutritional compositions such as bars or liquids suitable for oral administration. The combination of phosphatidyl serine, choline, and oleic acid provides synergistic or complimentary modes of action that improve the overall effect of these compounds.

Abstract translation: 本文描述了包含有效量的磷脂酰丝氨酸，胆碱和油酸的组合物，以及包括向受试者施用此类组合物的用于改善认知功能的方法。 组合物可以是营养组合物，例如适于口服给药的酒吧或液体。 磷脂酰丝氨酸，胆碱和油酸的组合提供增效或补充作用模式，改善这些化合物的总体效果。

公开(公告)号：WO2014043685A1

公开(公告)日：2014-03-20

申请号：PCT/US2013/060120

申请日：2013-09-17

Applicant: ABBOTT LABORATORIES

Inventor： SATHYAVAGEESWARAN, Shreeram ,  VAZHAPPILLY, Rema ,  DAS, Tapas ,  GELLING, Richard Wayne

IPC: A23L1/30 ,  A23L1/29 ,  A61K31/19 ,  A61P25/00

CPC classification number: A61K31/19 ,  A23L2/52 ,  A23L33/10 ,  A23L33/115 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A23L33/40 ,  A61K47/36 ,  A61K47/42 ,  A61K47/44

Abstract: Disclosed are compositions, such as liquid and solid nutritional compositions, that contain beta-hydroxy-beta-methylbutyric acid and optionally at least one protein, carbohydrate, fat, or a combination of protein, carbohydrate, and fat. Also disclosed are methods of using the compositions for improving physical endurance, locomotion, mobility and cognition in an individual, including a pediatric individual.

Abstract translation: 公开了含有β-羟基-β-甲基丁酸和任选的至少一种蛋白质，碳水化合物，脂肪或蛋白质，碳水化合物和脂肪的组合的组合物，例如液体和固体营养组合物。 还公开了使用组合物来改善包括儿科个体在内的个体的身体耐力，运动，移动性和认知的方法。

公开(公告)号：WO2013086330A1

公开(公告)日：2013-06-13

申请号：PCT/US2012/068462

申请日：2012-12-07

Applicant: ABBOTT LABORATORIES

Inventor： VAZHAPPILLY, Rema ,  DAS, Tapas

IPC: A23L1/29 ,  A23L1/30 ,  A61K31/12 ,  A61K31/202 ,  A61K36/906 ,  A61P25/28

CPC classification number: A61K31/202 ,  A23L33/105 ,  A23L33/115 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/322 ,  A23V2250/1868 ,  A23V2250/2112 ,  A61K31/12 ,  A61K36/9066 ,  A61K2300/00

Abstract: Disclosed are nutritional compositions including a combination of Curcumin and/or bioavailable Curcumin and docosahexaenoic acid. The combination improves cognitive performance in an individual, and, in one embodiment, improves a cognitive impairment and/or brain dysfunction associated with age-related cognitive decline or cognitive decline resulting from a neurodegenerative disease. This combination is also effective in improving memory acquisition, memory retention and recall in an individual.

Abstract translation: 公开了包括姜黄素和/或生物可利用的姜黄素和二十二碳六烯酸的组合的营养组合物。 该组合提高个体的认知表现，并且在一个实施方案中，改善与由神经变性疾病引起的年龄相关的认知衰退或认知衰退相关的认知障碍和/或脑功能障碍。 这种组合对于改善个人的记忆获取，记忆保留和回忆也是有效的。

公开(公告)号：WO2013086327A1

公开(公告)日：2013-06-13

申请号：PCT/US2012/068456

申请日：2012-12-07

Applicant: ABBOTT LABORATORIES

Inventor： VAZHAPPILLY, Rema ,  DAS, Tapas ,  BAXTER, Jeffrey H.

IPC: A23J7/00 ,  A23L1/22 ,  A23L1/29 ,  A23L1/30 ,  A61K31/12 ,  A61K31/202 ,  A61K31/685 ,  A61K36/9066

CPC classification number: A61K31/685 ,  A23L33/105 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/12 ,  A61K36/9066 ,  A23V2200/322 ,  A23V2250/1852 ,  A23V2250/1868 ,  A23V2250/2112 ,  A61K2300/00

Abstract: Disclosed are nutritional compositions including a combination of Curcumin and/or bioavailable Curcumin and phosphatidylserine-docosahexaenoic acid. The combination improves cognitive performance in an individual, and, in one embodiment, improves a cognitive impairment and/or brain dysfunction associated with age-related cognitive decline or cognitive decline resulting from a neurodegenerative disease. This combination is also effective in improving memory acquisition, memory retention and recall in an individual.

Abstract translation: 公开了包括姜黄素和/或生物可利用的姜黄素和磷脂酰丝氨酸 - 二十二碳六烯酸的组合的营养组合物。 该组合提高个体的认知表现，并且在一个实施方案中，改善与由神经变性疾病引起的年龄相关的认知衰退或认知衰退相关的认知障碍和/或脑功能障碍。 这种组合对于改善个人的记忆获取，记忆保留和回忆也是有效的。

公开(公告)号：EP3007690A1

公开(公告)日：2016-04-20

申请号：EP14733942.8

申请日：2014-06-10

Applicant: Abbott Laboratories

Inventor： VAZHAPPILLY, Rema ,  DAS, Tapas

IPC: A61K31/14 ,  A61K31/201 ,  A61K31/661 ,  A61P25/28

CPC classification number: A61K31/685 ,  A23L33/105 ,  A23L33/115 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/0095 ,  A61K31/14 ,  A61K31/201 ,  A61K31/661 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2250/1846 ,  A23V2250/1852 ,  A23V2250/188

Abstract: Compositions including an effective amount of each of phosphatidyl serine, choline, and oleic acid, and methods for improving cognitive performance that include administering such compositions to a subject, are described herein. The compositions can be nutritional compositions such as bars or liquids suitable for oral administration. The combination of phosphatidyl serine, choline, and oleic acid provides synergistic or complimentary modes of action that improve the overall effect of these compounds.

公开(公告)号：EP3068386A1

公开(公告)日：2016-09-21

申请号：EP14803026.5

申请日：2014-11-12

Applicant: ABBOTT LABORATORIES

Inventor： VAZHAPPILLY, Rema ,  LAI, Chron-Si ,  KUCHAN, Matthew

IPC: A61K31/355 ,  A61K31/20 ,  A61P11/00 ,  A61P25/00

CPC classification number: A61K31/355 ,  A23L33/10 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/047 ,  A61K31/20 ,  A61K31/202

Abstract: Disclosed herein are nutritional compositions for pregnant or lactating mothers, pre-term and term infants, toddlers and children which include natural vitamin E, a long chain polyunsaturated fatty acid (LC-PUFA) and a cartenoid such as lutein. Also disclosed are methods of administering these compositions for reducing or preventing the susceptibility of the fetal and newborn brain and lungs to hypoxia and the resulting disorders resulting therefrom including abnormal cognitive development, brain injury and lung injury.

Abstract translation: 公开在用于怀孕或哺乳期的母亲，早产和足月婴儿，幼儿和儿童的哪个包括天然维生素E，长链多不饱和脂肪酸（LC-PUFA）和类胡萝卜素的营养组合物：如叶黄素。 所以盘游离缺失是从包括异常认知发展，脑陪审团和肺损伤减少或预防胎儿和新生儿的脑部和肺部的易感性缺氧和所产生的所得的疾病有综合管理组合物的方法。

公开(公告)号：EP2895013A1

公开(公告)日：2015-07-22

申请号：EP13766463.7

申请日：2013-09-17

Applicant: ABBOTT LABORATORIES

Inventor： SATHYAVAGEESWARAN, Shreeram ,  VAZHAPPILLY, Rema ,  DAS, Tapas ,  GELLING, Richard Wayne

IPC: A23L1/30 ,  A23L1/29 ,  A61K31/19 ,  A61P25/00

CPC classification number: A61K31/19 ,  A23L2/52 ,  A23L33/10 ,  A23L33/115 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A23L33/40 ,  A61K47/36 ,  A61K47/42 ,  A61K47/44

Abstract: Disclosed are compositions, such as liquid and solid nutritional compositions, that contain beta-hydroxy-beta-methylbutyric acid and optionally at least one protein, carbohydrate, fat, or a combination of protein, carbohydrate, and fat. Also disclosed are methods of using the compositions for improving physical endurance, locomotion, mobility and cognition in an individual, including a pediatric individual.