公开(公告)号：WO2007050732A1

公开(公告)日：2007-05-03

申请号：PCT/US2006/041739

申请日：2006-10-27

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur, R. ,  BAYBURT, Erol, K. ,  KOENIG, John, R. ,  MARSH, Kennan, C. ,  SCHMIDT, Robert, G., Jr. ,  LEE, Chih-Hung ,  WANG, Weili ,  DAANEN, Jerome, F. ,  BROWN, Brian, S.

Inventor： GOMTSYAN, Arthur, R. ,  BAYBURT, Erol, K. ,  KOENIG, John, R. ,  MARSH, Kennan, C. ,  SCHMIDT, Robert, G., Jr. ,  LEE, Chih-Hung ,  WANG, Weili ,  DAANEN, Jerome, F. ,  BROWN, Brian, S.

IPC: C07D231/56 ,  C07D407/12 ,  A61K31/416 ,  A61P13/00

CPC classification number: C07D405/12 ,  C07D231/56 ,  C07D403/12 ,  C07F9/65038

Abstract: Compounds of formula (I), wherein A, R 1 , R 2 , and R 3 are defined in the specification, and which are useful as therapeutic compounds particularly for treating disorders or conditions associated with inflammation, pain, bladder overactivity, urinary incontinence, and other disorders caused by or exacerbated by TRPV1.

Abstract translation: 其中A，R 1，R 2和R 3的式（I）化合物在说明书中定义，并且它们是有用的 作为特别用于治疗与炎症，疼痛，膀胱过度活动，尿失禁以及由TRPV1引起或加剧的其它障碍有关的疾病或病症的治疗性化合物。

公开(公告)号：EP1957464A1

公开(公告)日：2008-08-20

申请号：EP06817391.3

申请日：2006-10-27

Applicant: ABBOTT LABORATORIES

Inventor： GOMTSYAN, Arthur, R. ,  BAYBURT, Erol, K. ,  KOENIG, John, R. ,  MARSH, Kennan, C. ,  SCHMIDT, Robert, G., Jr. ,  LEE, Chih-Hung ,  WANG, Weili ,  DAANEN, Jerome, F. ,  BROWN, Brian, S.

IPC: C07D231/56 ,  C07D407/12 ,  A61K31/416 ,  A61P13/00

CPC classification number: C07D405/12 ,  C07D231/56 ,  C07D403/12 ,  C07F9/65038

Abstract: Compounds of formula (I), wherein A, R1, R2, and R3 are defined in the specification, and which are useful as therapeutic compounds particularly for treating disorders or conditions associated with inflammation, pain, bladder overactivity, urinary incontinence, and other disorders caused by or exacerbated by TRPV1.