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    MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF
    2.
    发明申请
    MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF 审中-公开
    5-HT受体的调节剂及其使用方法

    公开(公告)号：WO2010124042A2

    公开(公告)日：2010-10-28

    申请号：PCT/US2010/031974

    申请日：2010-04-22

    Applicant: ABBOTT LABORATORIES ,  ABBOTT GMBH & CO. KG ,  WANG, Ying ,  BREWER, Jason, T. ,  AKRITOPOULOU-ZANZE, Irini ,  DJURIC, Stevan, W. ,  POHLKI, Frauke ,  BRAJE, Wilfried ,  RELO, Ana-Lucia

    Inventor： WANG, Ying ,  BREWER, Jason, T. ,  AKRITOPOULOU-ZANZE, Irini ,  DJURIC, Stevan, W. ,  POHLKI, Frauke ,  BRAJE, Wilfried ,  RELO, Ana-Lucia

    IPC: C07D498/04

    CPC classification number: C07D498/04 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D491/04

    Abstract: The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2- a ][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2- a ][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1 H -pyrido[3,4- d ][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2- a ][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7 H -pyrazino[1,2- a ][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1 H -pyrazino[2,1- d ][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2- d ]pyrido[3,2- b ][1,4]diazepine derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

    Abstract translation: 本申请涉及1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1,4]苯并二氮杂，1,2,3,4,4a， 7-八氢吡嗪并[1,2-a] [1,5]苯并二氮杂，2,3,4,4a，5,6,7,11b-八氢-1H-吡啶并[3,4-d] [2]苯并氮杂， 1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1]苯并氮杂，1,2,3,4,4a，5-六氢-7H-吡嗪并[1,2 -a] [4,1]苯并氧氮杂和2,3,4,4a，5,6-六氢-1H-吡嗪并[2,1-d] [1,5]苯并氧氮杂和5,6,7,7a ，其中R 1，R 2，R 3，R 4，R 5，R 6，R 6，R 5，R 6， X1，X2，X3，X4，Y1，Y2和Y3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

    3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES
    4.
    发明申请
    3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES 审中-公开
    3-喹啉基氨基取代的二价衍生物

    公开(公告)号：WO2005066166A2

    公开(公告)日：2005-07-21

    申请号：PCT/US2004/041366

    申请日：2004-12-10

    Applicant: ABBOTT LABORATORIES ,  JI, Jianguo ,  LI, Tao ,  WANG, Ying

    Inventor： JI, Jianguo ,  LI, Tao ,  WANG, Ying

    IPC: C07D453/00

    CPC classification number: C07D453/02

    Abstract: Compounds of formula (I); wherein A is N or N + -O - ; n is 0, 1, or 2; Y is O, S, -NH-, and -N-alkyl-; Ar 1 is both 6-membered aromatic rings; Ar 2 is 5- or 6-membered aromatic rings with a -NR 8 R 9 group, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

    Abstract translation: 式（I）化合物; 其中A是N或N + O - ; n为0,1或2; Y是O，S，-NH-和-N-烷基 - ; Ar 1是6元芳环; Ar 2是具有如本文所定义的-NR 8 R 9基团的5-或6-元芳环。 该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。 还公开了具有式（I）化合物的药物组合物和使用这些化合物和组合物的方法。

    3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES
    5.
    发明公开
    3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES 审中-公开
    3-喹啉基氨基取代的双芳基衍生物

    公开(公告)号：EP1699785A2

    公开(公告)日：2006-09-13

    申请号：EP04813664.2

    申请日：2004-12-10

    Applicant: ABBOTT LABORATORIES

    Inventor： JI, Jianguo ,  LI, Tao ,  WANG, Ying

    IPC: C07D453/00 ,  A61K31/439 ,  A61P25/00

    CPC classification number: C07D453/02

    Abstract: Compounds of formula (I); wherein A is N or N+-O-; n is 0, 1, or 2; Y is O, S, -NH-, and -N-alkyl-; Ar1 is both 6-membered aromatic rings; Ar2 is 5- or 6-membered aromatic rings with a -NR8R9 group, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

    Abstract translation: 式（I）化合物; 其中A是N或N + -O-; n是0,1或2; Y是O，S，-NH-和-N-烷基 - ; Ar1都是6元芳环; Ar 2是如本文所定义的具有-NR 8 R 9基团的5元或6元芳族环。 该化合物可用于治疗由α7nAChR配体阻止或改善的病症或障碍。 还公开了具有式（I）化合物的药物组合物和使用这些化合物和组合物的方法。

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