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公开(公告)号：WO2008002974A1
公开(公告)日：2008-01-03
申请号：PCT/US2007/072228
申请日：2007-06-27
Applicant: ABBOTT LABORATORIES , FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe
Inventor： FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe
IPC: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , A61K31/402 , A61P25/00
CPC classification number: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本发明涉及一系列取代的吡咯衍生物，包含其的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：WO2008073942A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/087090
申请日：2007-12-12
Applicant: ABBOTT LABORATORIES , GOPALAKRISHNAN, Murali , HONORE, Marie, P. , LEE, Chih-hung , MALYSZ, John , JI, Jianguo , LI, Tao , SCHRIMPF, Michael, R. , SIPPY, Kevin, B. , ANDERSON, David, J.
Inventor： GOPALAKRISHNAN, Murali , HONORE, Marie, P. , LEE, Chih-hung , MALYSZ, John , JI, Jianguo , LI, Tao , SCHRIMPF, Michael, R. , SIPPY, Kevin, B. , ANDERSON, David, J.
IPC: A61K31/4245 , A61P25/28 , A61K45/06
CPC classification number: A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
Abstract translation: 本发明涉及包含神经元烟碱性受体配体和a4β2正变构调节剂的组合物，其使用方法和相关制品。
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公开(公告)号：WO2009003074A3
公开(公告)日：2008-12-31
申请号：PCT/US2008/068264
申请日：2008-06-26
Applicant: ABBOTT LABORATORIES , GOPALAKRISHNAN, Murali , LI, Jinhe , CASSAR, Steven C , MALYSZ, John , ANDERSON, David J , GUBBINS, Earl J , BERTRAND, Daniel C
Inventor： GOPALAKRISHNAN, Murali , LI, Jinhe , CASSAR, Steven C , MALYSZ, John , ANDERSON, David J , GUBBINS, Earl J , BERTRAND, Daniel C
IPC: C07K14/435
Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.
Abstract translation: 本发明描述了新的胆碱能/ 5-羟色胺能嵌合受体并提供了适于筛选配体的方法和组合物，所述配体例如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。
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公开(公告)号：WO2008002956A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/072185
申请日：2007-06-27
Applicant: ABBOTT LABORATORIES , FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe , SARRIS, Kathy A. , MICHMERHUIZEN, Melissa J. , WANG, Ying
Inventor： FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe , SARRIS, Kathy A. , MICHMERHUIZEN, Melissa J. , WANG, Ying
CPC classification number: C07D417/04 , C07D413/04 , C07D417/14
Abstract: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
Abstract translation: 本发明涉及一系列噻唑啉和恶唑啉衍生物，其组合物，以及使用这些化合物治疗病症和病症的方法。
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Patent Agency Ranking
公开(公告)号：EP2173764A2
公开(公告)日：2010-04-14
申请号：EP08771975.3
申请日：2008-06-26
Applicant: Abbott Laboratories
Inventor： GOPALAKRISHNAN, Murali , LI, Jinhe , CASSAR, Steven C , MALYSZ, John , ANDERSON, David J , GUBBINS, Earl J , BERTRAND, Daniel C
IPC: C07K14/435
CPC classification number: C07K14/723 , C07K14/70571 , G01N33/566 , G01N2500/04
Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.
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公开(公告)号：EP2101763B1
公开(公告)日：2012-07-18
申请号：EP07869109.4
申请日：2007-12-12
Applicant: ABBOTT LABORATORIES
Inventor： GOPALAKRISHNAN, Murali , HONORE, Marie P. , LEE, Chih-hung , MALYSZ, John , JI, Jianguo , LI, Tao , SCHRIMPF, Michael R. , SIPPY, Kevin B. , ANDERSON, David J.
IPC: A61K31/4245 , A61P25/28 , A61K45/06
CPC classification number: A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
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公开(公告)号：EP2038278A2
公开(公告)日：2009-03-25
申请号：EP07812349.4
申请日：2007-06-27
Applicant: ABBOTT LABORATORIES
Inventor： FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe , SARRIS, Kathy A. , MICHMERHUIZEN, Melissa J. , WANG, Ying
IPC: C07D417/04 , C07D413/04 , C07D417/14 , A61K31/422 , A61K31/427
CPC classification number: C07D417/04 , C07D413/04 , C07D417/14
Abstract: The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are regulated by the nicotinic acetylcholine receptors.
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公开(公告)号：EP2101763A2
公开(公告)日：2009-09-23
申请号：EP07869109.4
申请日：2007-12-12
Applicant: ABBOTT LABORATORIES
Inventor： GOPALAKRISHNAN, Murali , HONORE, Marie P. , LEE, Chih-hung , MALYSZ, John , JI, Jianguo , LI, Tao , SCHRIMPF, Michael R. , SIPPY, Kevin B. , ANDERSON, David J.
IPC: A61K31/4245 , A61P25/28 , A61K45/06
CPC classification number: A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
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公开(公告)号：EP2041085A1
公开(公告)日：2009-04-01
申请号：EP07812375.9
申请日：2007-06-27
Applicant: ABBOTT LABORATORIES
Inventor： FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe
IPC: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , A61K31/402 , A61P25/00
CPC classification number: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
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