公开(公告)号：WO2004027426A2

公开(公告)日：2004-04-01

申请号：PCT/US2003/028398

申请日：2003-09-10

Applicant: ABBOTT LABORATORIES

Inventor： PAN, Jeffrey, Y. ,  NEMCEK, Thomas, A. ,  GONZALEZ, Carlos ,  MASLANA, Eugene, S. ,  SABET, Reza, S. ,  DONNELLY, Jennifer, B. ,  BURNS, David, J. ,  GROEBE, Duncan, R. ,  WARRIOR, Usha

IPC: G01N33/543

CPC classification number: G01N33/559 ,  B01J19/0046 ,  B01J2219/0036 ,  B01J2219/00364 ,  B01J2219/00382 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00725 ,  B01J2219/0074 ,  C40B40/10 ,  C40B60/14 ,  G01N33/5436 ,  G01N2500/00

Abstract: A method for testing a multiplicity of chemical entities for the ability of these chemical entities to enhance or inhibit abiological process. In one embodiment, the method comprises the steps of: (a) providing a blank matrix having at least two major surfaces, the at least two major surfaces capable of receiving assay components and chemical entities; (b) applying at least one chemical entity to at least one of the at least two major surfaces of the blank matrix, whereby an impregnated matrix is formed; (c) applying to at least one of the at least two major surfaces ofthe impregnated matrix at least one assay component required for a biological process; and (d) evaluating the ability of the at least one chemical entity to enhance or inhibit the biological process involving the at least one assaycomponent. In the preferred embodiments, a response indicative of an enhancement or an inhibition of the aforementioned biological process can be detected by a tracer, which can be introduced to the impregnated matrix as an assay component. The response so detected can be preserved in the form of an image of the at least one of the two major surfaces of the impregnated matrix.

Abstract translation: 用于测试这些化学实体增强或抑制无生物过程的能力的多种化学实体的方法。 在一个实施方案中，所述方法包括以下步骤：（a）提供具有至少两个主表面的空白基质，所述至少两个主表面能够接受化验组分和化学实体; （b）将至少一种化学实体施加到坯体基体的至少两个主表面中的至少一个上，由此形成浸渍的基体; （c）向浸渍基质的至少两个主表面中的至少一个施加生物过程所需的至少一种测定组分; 和（d）评估所述至少一种化学实体增强或抑制涉及所述至少一种化验组分的生物学过程的能力。 在优选的实施方案中，指示上述生物过程的增强或抑制的应答可以通过示踪剂检测，示踪剂可以作为测定组分引入浸渍基质。 如此检测到的响应可以以浸渍基质的两个主表面中的至少一个的图像的形式保存。

公开(公告)号：EP1539343A2

公开(公告)日：2005-06-15

申请号：EP03797896.2

申请日：2003-09-10

Applicant: Abbott Laboratories

Inventor： PAN, Jeffrey, Y. ,  NEMCEK, Thomas, A. ,  GONZALEZ, Carlos ,  MASLANA, Eugene, S. ,  SABET, Reza, S. ,  DONNELLY, Jennifer, B. ,  BURNS, David, J. ,  GROEBE, Duncan, R. ,  WARRIOR, Usha

IPC: B01J19/00 ,  G01N33/559 ,  G01N33/543 ,  G01N33/549

CPC classification number: G01N33/559 ,  B01J19/0046 ,  B01J2219/0036 ,  B01J2219/00364 ,  B01J2219/00382 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00725 ,  B01J2219/0074 ,  C40B40/10 ,  C40B60/14 ,  G01N33/5436 ,  G01N2500/00

Abstract: A method for testing a multiplicity of chemical entities for the ability of these chemical entities to enhance or inhibit abiological process. In one embodiment, the method comprises the steps of: (a) providing a blank matrix having at least two major surfaces, the at least two major surfaces capable of receiving assay components and chemical entities; (b) applying at least one chemical entity to at least one of the at least two major surfaces of the blank matrix, whereby an impregnated matrix is formed; (c) applying to at least one of the at least two major surfaces ofthe impregnated matrix at least one assay component required for a biological process; and (d) evaluating the ability of the at least one chemical entity to enhance or inhibit the biological process involving the at least one assaycomponent. In the preferred embodiments, a response indicative of an enhancement or an inhibition of the aforementioned biological process can be detected by a tracer, which can be introduced to the impregnated matrix as an assay component. The response so detected can be preserved in the form of an image of the at least one of the two major surfaces of the impregnated matrix.

公开(公告)号：EP1068187A1

公开(公告)日：2001-01-17

申请号：EP99915341.4

申请日：1999-04-08

Applicant: ABBOTT LABORATORIES

Inventor： BA MAUNG, Nwe, Y. ,  BASHA, Anwer ,  DJURIC, Stevan, W. ,  GUBBINS, Earl, J. ,  LULY, Jay, R. ,  TU, Noah, P. ,  MADAR, David, J. ,  WARRIOR, Usha ,  WIEDEMAN, Paul, E. ,  ZHOU, Xun ,  WAGENAAR, Frank, L. ,  SCIOTTI, Richard, J.

IPC: C07D231/16 ,  A61K31/475 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/445 ,  A61K31/415 ,  C07D405/10 ,  C07D403/10 ,  C07D495/04 ,  C07D409/10 ,  C07D417/10 ,  C07D401/10 ,  C07D413/10 ,  C07D401/04 ,  C07D409/04 ,  C07D401/14 ,  C07D417/14 ,  C07D405/14

CPC classification number: C07D401/04 ,  C07D231/16 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D405/10 ,  C07D405/14 ,  C07D409/04 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/14 ,  C07D495/04

Abstract: Compounds having formula (I) are useful for treating diseases that are prevented by or ameliorated with Interleukin-2, Interleukin-4, or Interleukin-5 production inhibitors.