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    METHOD FOR USING A BLANK MATRIX IN A CONTINUOUS FORMAT HIGH THROUGHPUT SCREENING PROCESS
    1.
    发明申请
    METHOD FOR USING A BLANK MATRIX IN A CONTINUOUS FORMAT HIGH THROUGHPUT SCREENING PROCESS 审中-公开
    在连续格式中使用空白矩阵的方法高通过筛选过程

    公开(公告)号：WO2004027426A2

    公开(公告)日：2004-04-01

    申请号：PCT/US2003/028398

    申请日：2003-09-10

    Applicant: ABBOTT LABORATORIES

    Inventor： PAN, Jeffrey, Y. ,  NEMCEK, Thomas, A. ,  GONZALEZ, Carlos ,  MASLANA, Eugene, S. ,  SABET, Reza, S. ,  DONNELLY, Jennifer, B. ,  BURNS, David, J. ,  GROEBE, Duncan, R. ,  WARRIOR, Usha

    IPC: G01N33/543

    CPC classification number: G01N33/559 ,  B01J19/0046 ,  B01J2219/0036 ,  B01J2219/00364 ,  B01J2219/00382 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00725 ,  B01J2219/0074 ,  C40B40/10 ,  C40B60/14 ,  G01N33/5436 ,  G01N2500/00

    Abstract: A method for testing a multiplicity of chemical entities for the ability of these chemical entities to enhance or inhibit abiological process. In one embodiment, the method comprises the steps of: (a) providing a blank matrix having at least two major surfaces, the at least two major surfaces capable of receiving assay components and chemical entities; (b) applying at least one chemical entity to at least one of the at least two major surfaces of the blank matrix, whereby an impregnated matrix is formed; (c) applying to at least one of the at least two major surfaces ofthe impregnated matrix at least one assay component required for a biological process; and (d) evaluating the ability of the at least one chemical entity to enhance or inhibit the biological process involving the at least one assaycomponent. In the preferred embodiments, a response indicative of an enhancement or an inhibition of the aforementioned biological process can be detected by a tracer, which can be introduced to the impregnated matrix as an assay component. The response so detected can be preserved in the form of an image of the at least one of the two major surfaces of the impregnated matrix.

    Abstract translation: 用于测试这些化学实体增强或抑制无生物过程的能力的多种化学实体的方法。 在一个实施方案中，所述方法包括以下步骤：（a）提供具有至少两个主表面的空白基质，所述至少两个主表面能够接受化验组分和化学实体; （b）将至少一种化学实体施加到坯体基体的至少两个主表面中的至少一个上，由此形成浸渍的基体; （c）向浸渍基质的至少两个主表面中的至少一个施加生物过程所需的至少一种测定组分; 和（d）评估所述至少一种化学实体增强或抑制涉及所述至少一种化验组分的生物学过程的能力。 在优选的实施方案中，指示上述生物过程的增强或抑制的应答可以通过示踪剂检测，示踪剂可以作为测定组分引入浸渍基质。 如此检测到的响应可以以浸渍基质的两个主表面中的至少一个的图像的形式保存。

    APPARATUS AND METHOD FOR ELECTROPHYSIOLOGICAL TESTING
    4.
    发明公开
    APPARATUS AND METHOD FOR ELECTROPHYSIOLOGICAL TESTING 审中-公开
    用于电生理测试的装置和方法

    公开(公告)号：EP1266219A2

    公开(公告)日：2002-12-18

    申请号：EP01922545.7

    申请日：2001-03-21

    Applicant: ABBOTT LABORATORIES

    Inventor： TRUMBULL, Jonathan, D. ,  BERTRAND, Daniel, C. ,  BRIGGS, Clark, A. ,  MCKENNA, David, G. ,  MASLANA, Eugene, S. ,  BLANCHARD, David, P. ,  PAN, Jeffrey, Y. ,  BOJAN, Peter, M. ,  NEMCEK, Thomas, A.

    IPC: G01N33/487 ,  G01N35/02 ,  G01N33/50

    CPC classification number: G01N35/028

    Abstract: A method and apparatus for running a plurality of tests concurrently to obtain data relating to the electrophysiological properties of receptors and channels in biological membranes of test subjects, such as, for example, Xenopus oocytes. The invention further provides software for controlling, acquiring, and recording data relating to electrophysiological properties of receptors and channels in biological membranes of test subjects, such as, for example, oocytes. This invention increases the throughput rate for experiments and assays employing receptors and ion channels expressed in biological membranes of test subjects, such as, for example, oocytes. In the case of an oocyte, these receptors and channels may be natively expressed (endogenous), may be placed into the oocyte (exogenous), or may be expressed from other RNA or DNA previously placed into the oocyte (exogenous). The invention provides a means for a sole researcher to operate a plurality of electrophysiological test stations in the time and space conventionally required by a single electrophysiological test station. The invention automates these stations and provides a means for a sole individual to perform large sets of experiments that would be physically and mentally exhausting in the absence of this invention. In addition, this invention provides efficient database and data analysis software integrated with the data acquisition software, thereby increasing the user's data-handling productivity to keep pace with the augmented data generation capacity.

    Abstract translation: 用于同时运行多个测试以获得与测试受试者（例如非洲爪蟾卵母细胞）的生物膜中的受体和通道的电生理学特性有关的数据的方法和装置。 本发明进一步提供了用于控制，获取和记录与受试者（例如卵母细胞）的生物膜中的受体和通道的电生理学特性有关的数据的软件。 本发明提高了使用受试者（例如卵母细胞）的生物膜中表达的受体和离子通道的实验和测定的通过率。 在卵母细胞的情况下，这些受体和通道可以是天然表达的（内源性的），可以被置于卵母细胞中（外源性的），或者可以从先前置于卵母细胞（外源性）的其他RNA或DNA中表达。 本发明提供了一种用于唯一研究者在单个电生理测试站通常所需的时间和空间中操作多个电生理学测试站的手段。 本发明使这些站自动化，并为单个人提供了一种手段，用于执行大量的实验，在没有本发明的情况下，这些实验在身体上和精神上都会耗尽。 此外，本发明提供了与数据采集软件集成的高效数据库和数据分析软件，从而提高了用户的数据处理生产率，以跟上增强的数据生成能力。

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