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    ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES,ADJUVANTS,AND INTIVIRAL,ANTIBACTERIAL,AND ANTICANCER AGENTS
    4.
    发明专利
    ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES,ADJUVANTS,AND INTIVIRAL,ANTIBACTERIAL,AND ANTICANCER AGENTS 未知

    公开(公告)号：ZA201101128B

    公开(公告)日：2013-11-27

    申请号：ZA201101128

    申请日：2011-02-11

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN ,  LIN KUN-HSIEN ,  HUNG JUNG-TUNG

    IPC: A61K20060101 ,  A61P20060101

    Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect. a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1: or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.

    ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES, ADJUVANTS, AND INTIVIRAL, ANTIBACTERIAL, AND ANTICANCER AGENTS
    7.
    发明申请
    ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES, ADJUVANTS, AND INTIVIRAL, ANTIBACTERIAL, AND ANTICANCER AGENTS 审中-公开
    ALPHA-GALACTOSYL CERAMIDE ANALOGS及其作为免疫抑制剂，调节剂和杀虫剂，抗真菌剂和抗原剂的用途

    公开(公告)号：WO2010006315A3

    公开(公告)日：2010-03-25

    申请号：PCT/US2009050328

    申请日：2009-07-10

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN ,  LIN KUN-HSIEN ,  CHENG Y S EDMOND ,  JAN JIA-TSRONG ,  LIN YI-LING ,  HUNG JUNG-TUNG

    Inventor： WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN ,  LIN KUN-HSIEN ,  CHENG Y S EDMOND ,  JAN JIA-TSRONG ,  LIN YI-LING ,  HUNG JUNG-TUNG

    IPC: A61K39/39 ,  A61K31/70 ,  A61P31/04 ,  A61P31/16 ,  A61P35/00

    CPC classification number: C07H15/18 ,  A61K31/7034 ,  A61K39/0011 ,  A61K2039/57

    Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (a- GalCer) analogs, and their use as immunotherapies, adjuvants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1 :; or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.

    Abstract translation: 本公开内容涉及合成的α-半乳糖神经酰胺（a-GalCer）类似物，以及它们作为免疫疗法，佐剂和抗病毒，抗菌和抗癌剂的用途。 一方面，在受试者中激活细胞因子应答的方法包括向受试者施用有效量的化合物，其中所述受试者具有包括细胞群的适应性免疫系统，所述群体包括至少一种淋巴细胞和 至少一种抗原呈递细胞，并且其中所述化合物由式1的结构表示： 或其药学上可接受的盐; 在化合物和抗原呈递细胞之间形成复合物，其中复合物的形成导致淋巴细胞上受体的活化; 并激活淋巴细胞以产生细胞因子反应。

    ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES
    8.
    发明申请
    ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES 审中-公开
    ALPHA-GALACTOSYL CERAMIDE ANALOGS及其作为免疫球蛋白使用

    公开(公告)号：WO2008128207A1

    公开(公告)日：2008-10-23

    申请号：PCT/US2008060275

    申请日：2008-04-14

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN

    Inventor： WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN

    IPC: A61K8/42 ,  A61K8/00 ,  C07C235/80 ,  C07C237/10

    CPC classification number: C07H15/26 ,  A61K8/68 ,  A61K2800/91 ,  A61Q17/005 ,  C07H15/06 ,  C07H15/18

    Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (a-GalCer) analogs, and their use as immunotherapies. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula (1) wherein, n is 0 to 25; X is selected from O and S; R 1 is selected from H, CH 3 , and phenyl, where phenyl is optionally substituted with H, OH, OCH 3 , F, CF 3 , phenyl, phenyl-F, C 1 -C 6 alkyl, or C 2 -C 6 branched alkyl; R 2 is selected from OH and H; R 3 is selected from C 1 -C 15 alkyl, and phenyl, where phenyl is optionally substituted with H, OH, OCH 3 , F, CF 3 , phenyl, C 1 -C 6 alkyl, or C 2 -C 6 branched alkyl; R 4 is selected from OH, OSO 3 H, OSO 3 Na, and OSO 3 K; and R 5 is selected from CH 2 OH and CO 2 H; or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.

    Abstract translation: 本公开内容涉及合成的α-半乳糖神经酰胺（a-GalCer）类似物，以及它们作为免疫治疗的用途。 一方面，在受试者中激活细胞因子应答的方法包括向受试者施用有效量的化合物，其中所述受试者具有包括细胞群的适应性免疫系统，所述群体包括至少一种淋巴细胞和 至少一个抗原呈递细胞，并且其中所述化合物由式（1）的结构表示，其中n为0至25; X选自O和S; R 1选自H，CH 3和苯基，其中苯基任选被H，OH，OCH 3，F，CF 苯基，苯基-F，C 1 -C 6烷基或C 2 -C 6亚烷基 >支链烷基; R 2选自OH和H; R 3选自C 1 -C 15烷基和苯基，其中苯基任选被H，OH，OCH 3取代， 3，F，CF 3，苯基，C 1 -C 6烷基或C 2 H 2 -C 6 -C 6支链烷基; R 4选自OH，OSO 3 H，OSO 3 Na和OSO 3 K; 和R 5选自CH 2 OH和CO 2 H; 或其药学上可接受的盐; 在化合物和抗原呈递细胞之间形成复合物，其中复合物的形成导致淋巴细胞上受体的活化; 并激活淋巴细胞以产生细胞因子反应。

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