公开(公告)号：DK2568976T3

公开(公告)日：2016-01-11

申请号：DK11731548

申请日：2011-05-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  CHENG YIH-SHYUN ,  SHIE JIUN-JIE

IPC: A61K31/00 ,  A61K31/665 ,  A61K31/683

公开(公告)号：CA2835489A1

公开(公告)日：2011-11-17

申请号：CA2835489

申请日：2011-05-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  CHENG YIH-SHYUN ,  SHIE JIUN-JIE

IPC: A61K31/7024 ,  A61P31/16 ,  G01N33/573

Abstract: Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of oseltamivir-resistant influenza viruses by competitive binding assays utilizing non- oseltamivir influenza virus neuraminidase inhibitors and oseltamivir carboxylate are provided. Influenza virus neuraminidase inhibitors coupled to sensors and useful for employment in the methods of the invention are disclosed. Novel phosphonate compounds active as neuraminidase inhibitors against wild-type and oseltamivir-resistant influenza strains of H1N1, H5N1 and H3N2 viruses are disclosed. An enantioselective synthetic route to preparation of these phosphonate compounds via sialic acid is provided.

公开(公告)号：DK2975409T3

公开(公告)日：2018-12-17

申请号：DK15181446

申请日：2011-05-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  CHENG YIH-SHYUN ,  SHIE JIUN-JIE

IPC: G01N33/569

公开(公告)号：CA2835489C

公开(公告)日：2018-03-06

申请号：CA2835489

申请日：2011-05-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  CHENG YIH-SHYUN ,  SHIE JIUN-JIE

IPC: A61K31/7008 ,  A61P31/16 ,  C07F9/655 ,  G01N33/569 ,  G01N33/573

Abstract: Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of oseltamivir-resistant influenza viruses by competitive binding assays utilizing non- oseltamivir influenza virus neuraminidase inhibitors and oseltamivir carboxylate are provided. Influenza virus neuraminidase inhibitors coupled to sensors and useful for employment in the methods of the invention are disclosed. Novel phosphonate compounds active as neuraminidase inhibitors against wild-type and oseltamivir-resistant influenza strains of H1N1, H5N1 and H3N2 viruses are disclosed. An enantioselective synthetic route to preparation of these phosphonate compounds via sialic acid is provided.