公开(公告)号：CA2981883A1

公开(公告)日：2016-10-20

申请号：CA2981883

申请日：2016-04-12

Applicant: ACADEMIA SINICA

Inventor： WU HAN-CHUNG ,  LU RUEI-MIN ,  CHIU CHIUNG-YI ,  LIU I-JU ,  CHANG YU-LING

IPC: C07K16/28

Abstract: An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74) is disclosed. The epitope within the domain 3 of the VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. Use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting tumor growth, tumor angiogenesis, and/or inducing cancer cell cytotoxicity in a subject in need thereof is also disclosed. Also disclosed is a method of detecting the presence of VEGFR2 in a tumor vascular endothelial cell or a cancer cell in a biological sample.

公开(公告)号：AU2016249991A1

公开(公告)日：2017-10-12

申请号：AU2016249991

申请日：2016-04-12

Applicant: ACADEMIA SINICA

Inventor： WU HAN-CHUNG ,  LU RUEI-MIN ,  CHIU CHIUNG-YI ,  LIU I-JU ,  CHANG YU-LING

IPC: C07K16/28

Abstract: An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74) is disclosed. The epitope within the domain 3 of the VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. Use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting tumor growth, tumor angiogenesis, and/or inducing cancer cell cytotoxicity in a subject in need thereof is also disclosed. Also disclosed is a method of detecting the presence of VEGFR2 in a tumor vascular endothelial cell or a cancer cell in a biological sample.

公开(公告)号：ES2882276T3

公开(公告)日：2021-12-01

申请号：ES16780542

申请日：2016-04-12

Applicant: ACADEMIA SINICA

Inventor： WU HAN-CHUNG ,  LU RUEI-MIN ,  CHIU CHIUNG-YI ,  LIU I-JU ,  CHANG YU-LING

IPC: C07K16/28 ,  A61K31/33 ,  A61K39/395 ,  A61P35/00 ,  A61P35/02 ,  C07K16/30 ,  C12N15/11

Abstract: Un anticuerpo o un fragmento de unión a antígeno del mismo que tiene una afinidad de unión específica a un epítope que se encuentra dentro del dominio 3 del receptor 2 del factor de crecimiento endotelial vascular humano (VEGFR2; SEQ ID NO: 74), en donde el epítope dentro del dominio 3 del VEGFR2 se encuentra entre los residuos de aminoácidos 250 y 270 de SEQ ID NO: 74, y además en donde el anticuerpo o fragmento de unión a antígeno del mismo comprende una región variable de cadena pesada (VH) y una región variable de cadena ligera (VL), la VH comprende VH CDR1, VH CDR2 y VH CDR3 y la VL comprende VL CDR1, VL CDR2 y VL CDR3, en donde: la VH CDR1, VH CDR2 y VH CDR3 comprenden la secuencia de aminoácidos de SEQ ID NO: 6, SEQ ID NO: 7 y SEQ ID NO: 8, respectivamente; y la VL CDR1, VL CDR2 y VL CDR3 comprenden la secuencia de aminoácidos de SEQ ID NO: 9, Asp Ala Ser y SEQ ID NO: 73, respectivamente.

公开(公告)号：CA2981883C

公开(公告)日：2019-10-22

申请号：CA2981883

申请日：2016-04-12

Applicant: ACADEMIA SINICA

Inventor： WU HAN-CHUNG ,  LU RUEI-MIN ,  CHIU CHIUNG-YI ,  LIU I-JU ,  CHANG YU-LING

IPC: C07K16/28

Abstract: An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74) is disclosed. The epitope within the domain 3 of the VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. Use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting tumor growth, tumor angiogenesis, and/or inducing cancer cell cytotoxicity in a subject in need thereof is also disclosed. Also disclosed is a method of detecting the presence of VEGFR2 in a tumor vascular endothelial cell or a cancer cell in a biological sample.

公开(公告)号：AU2016249991B2

公开(公告)日：2021-03-25

申请号：AU2016249991

申请日：2016-04-12

Applicant: ACADEMIA SINICA

Inventor： WU HAN-CHUNG ,  LU RUEI-MIN ,  CHIU CHIUNG-YI ,  LIU I-JU ,  CHANG YU-LING

IPC: C07K16/28

Abstract: An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74) is disclosed. The epitope within the domain 3 of the VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. Use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting tumor growth, tumor angiogenesis, and/or inducing cancer cell cytotoxicity in a subject in need thereof is also disclosed. Also disclosed is a method of detecting the presence of VEGFR2 in a tumor vascular endothelial cell or a cancer cell in a biological sample.

公开(公告)号：SG11201707949XA

公开(公告)日：2017-10-30

申请号：SG11201707949X

申请日：2016-04-12

Applicant: ACADEMIA SINICA

Inventor： WU HAN-CHUNG ,  LU RUEI-MIN ,  CHIU CHIUNG-YI ,  LIU I-JU ,  CHANG YU-LING

IPC: C07K16/28

Abstract: An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74) is disclosed. The epitope within the domain 3 of the VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. Use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting tumor growth, tumor angiogenesis, and/or inducing cancer cell cytotoxicity in a subject in need thereof is also disclosed. Also disclosed is a method of detecting the presence of VEGFR2 in a tumor vascular endothelial cell or a cancer cell in a biological sample.