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公开(公告)号:CA2981883A1
公开(公告)日:2016-10-20
申请号:CA2981883
申请日:2016-04-12
Applicant: ACADEMIA SINICA
Inventor: WU HAN-CHUNG , LU RUEI-MIN , CHIU CHIUNG-YI , LIU I-JU , CHANG YU-LING
IPC: C07K16/28
Abstract: An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74) is disclosed. The epitope within the domain 3 of the VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. Use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting tumor growth, tumor angiogenesis, and/or inducing cancer cell cytotoxicity in a subject in need thereof is also disclosed. Also disclosed is a method of detecting the presence of VEGFR2 in a tumor vascular endothelial cell or a cancer cell in a biological sample.
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公开(公告)号:CA2809677A1
公开(公告)日:2012-03-08
申请号:CA2809677
申请日:2011-08-30
Applicant: ACADEMIA SINICA , LIANG CHI MING
Inventor: WU HAN-CHUNG , LU RUEI-MIN
IPC: C07K16/30 , A61K9/14 , A61K39/395 , A61P35/00 , C07K16/28 , C07K17/02 , C12N15/13 , G01N33/574
Abstract: Antibodies that bind to c-Met are provided herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies and diagnostics. In certain embodiments, antibodies bind mammalian cell surface antigen (e.g., cancer cell surface antigen). The antibodies can also be endocytosed upon binding to cells. Cells that can be targeted by the antibodies include carcinomas, such as those in lung, kidney, liver, stomach, breast, and brain, etc.
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公开(公告)号:SG173593A1
公开(公告)日:2011-09-29
申请号:SG2011057023
申请日:2010-02-19
Applicant: ACADEMIA SINICA , LIANG CHI MING
Inventor: WU HAN-CHUNG , CHIU CHIEN-YU
Abstract: Cancer-targeting peptides and uses thereof in cancer therapy.
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公开(公告)号:AU2015377230A1
公开(公告)日:2017-07-13
申请号:AU2015377230
申请日:2015-07-13
Applicant: ACADEMIA SINICA
Inventor: WONG CHI-HUEY , HSU TSUI-LING , LOU YI-WEI , LIN CHIH-WEI , YEH SHIHH-CHI , WU CHUNG-YI , WU HAN-CHUNG
Abstract: Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and/or prostate cancer.
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公开(公告)号:CA2973886A1
公开(公告)日:2016-08-04
申请号:CA2973886
申请日:2016-01-30
Applicant: ACADEMIA SINICA
Inventor: WONG CHI-HUEY , WU CHUNG-YI , MA CHE , WU HAN-CHUNG
Abstract: The present disclosure relates to compositions and methods of use comprising antibodies or binding fragments thereof further comprising universal Fc glycoforms.
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公开(公告)号:CA2972067A1
公开(公告)日:2016-07-21
申请号:CA2972067
申请日:2015-07-13
Applicant: ACADEMIA SINICA
Inventor: WONG CHI-HUEY , HSU TSUI-LING , LOU YI-WEI , LIN CHIH-WEI , YEH SHIHH-CHI , WU CHUNG-YI , WU HAN-CHUNG
Abstract: Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and/or prostate cancer.
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公开(公告)号:AU2015206370A1
公开(公告)日:2016-07-07
申请号:AU2015206370
申请日:2015-01-16
Applicant: ACADEMIA SINICA
Inventor: LOU YI-WEI , LIN CHIH-WEI , YEH SHIH-CHI , HSU TSUI-LING , WU CHUNG-YI , WU HAN-CHUNG , WONG CHI-HUEY
IPC: C12N5/0793
Abstract: Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, lung, breast, mouse, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervix, ovary, and/or prostate cancer.
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公开(公告)号:AU2011296085A1
公开(公告)日:2013-03-28
申请号:AU2011296085
申请日:2011-08-30
Applicant: ACADEMIA SINICA , LIANG CHI MING
Inventor: WU HAN-CHUNG , LU RUEI-MIN
IPC: C12P21/06
Abstract: Antibodies that bind to c-Met are provided herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies and diagnostics. In certain embodiments, antibodies bind mammalian cell surface antigen (e.g., cancer cell surface antigen). The antibodies can also be endocytosed upon binding to cells. Cells that can be targeted by the antibodies include carcinomas, such as those in lung, kidney, liver, stomach, breast, and brain, etc.
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公开(公告)号:CA2678013A1
公开(公告)日:2008-08-21
申请号:CA2678013
申请日:2008-02-12
Applicant: ACADEMIA SINICA , UNIV NAT TAIWAN
Inventor: LIN CHIN-TARNG , WU HAN-CHUNG , CHANG DE-KUAN
Abstract: The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target lung canc er and were identified by phage display. Targeting phage PC5-2 and synthetic peptide SP5-2 were both able to recognize human pulmonary tumor specimens f rom lung cancer patients. In SCID mice bearing NSCLC xenografts, the targeti ng phage was able to target tumor masses specifically. When the peptide was coupled to liposomes containing the anti-cancer drugs vinorelbine or doxorub icin, the efficacy of these drugs against human lung cancer xenografts was i mproved, the survival rate increased, and the drug toxicity was reduced.
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公开(公告)号:CA2678051A1
公开(公告)日:2008-02-21
申请号:CA2678051
申请日:2008-02-12
Applicant: ACADEMIA SINICA , UNIV NAT TAIWAN
Inventor: WU HAN-CHUNG , LIN CHIN-TARNG , LEE TONG-YOUNG , KUO SZU-YAO
Abstract: The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovascul ature and were identified by in vivo phage display. One such peptide, SP5-52 , recognized the neovasculature of multiple tumors in SCED mice, but did not target normal blood vessels. This peptide also binds to blood vessels of hu man lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubici n enhanced the efficacy of the drug against multiple human cancer xenografts in SCED mice.
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