中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

13 records (took 0.019 seconds)

    RISK ASSESSMENT FOR ADVERSE DRUG REACTIONS
    7.
    发明专利
    RISK ASSESSMENT FOR ADVERSE DRUG REACTIONS 未知

    公开(公告)号：CA2544369C

    公开(公告)日：2014-08-05

    申请号：CA2544369

    申请日：2004-06-18

    Applicant: ACADEMIA SINICA

    Inventor： CHEN YUAN-TSONG ,  HUNG SHUEN-IU ,  CHUNG WEN-HUNG ,  WU JER-YUARN

    IPC: C12Q1/68 ,  G01N33/94

    Abstract: The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug hypersensitivity syndrome (HSS). It was discovered that an HLA-13 allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most significant for carbamazepine-induced SJS/TEN, wherein all the patients tested have the HLA-13*1502 allele. In addition, another HLA-13 allele, HLA-B*5801, is particularly associated with SJS/TEN or HSS induced by allopurinol. Milder cutaneous reactions, such as maculopapular rash, erythema multiforme (EM), urticaria, and fixed drug eruption, are particularly associated with a third allele, HLA-13*4601. For any of the alleles, genetic markers (e.g., HLA markers, microsatellite, or single nucleotide polymorphism markers) located between the DRB1 and HLA-A region of the specific HLA-B haplotype can also be used for the test.

Patent Agency Ranking