公开(公告)号：MX2017002333A

公开(公告)日：2017-08-28

申请号：MX2017002333

申请日：2015-08-21

Applicant: ACADEMIA SINICA

Inventor： HSIN-YU LEE ,  CHUNG-YI WU ,  CHI-HUEY WONG

IPC: C07K14/33 ,  C07K14/34

Abstract: Esta divulgación incluye una composición inmunogenica que contiene (a) a un conjunto de glicano que incluye un portador y uno o más glicanos, en donde cada uno de los uno o más glicanos se conjugan con el portador mediante un enlazador, y opcionalmente (b) un adyuvante. Los uno o más glicanos son cada uno un derivado de Globo H.

公开(公告)号：IL264873B2

公开(公告)日：2023-08-01

申请号：IL26487319

申请日：2019-02-17

Applicant: CHO PHARMA INC ,  ACADEMIA SINICA ,  LIN NAN HORNG ,  LIN YA HUANG ,  SACHIN S SHIVATARE ,  LI TZU CHEN ,  CHI HUEY WONG ,  CHUNG YI WU ,  TING CHENG

Inventor： LIN NAN-HORNG ,  LIN-YA HUANG ,  SACHIN S SHIVATARE ,  LI-TZU CHEN ,  CHI-HUEY WONG ,  CHUNG-YI WU ,  TING CHENG

IPC: A61K39/00 ,  A61P35/00 ,  A61P35/02 ,  C07K16/28 ,  C12P21/00

Abstract: A mutant of EndoS2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO:1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of EndoS2 has a low hydrolyzing activity and a high tranglycosylation activity, as compared to those of the wild-type EndoS2. A method for preparing an engineered glycoprotein using the mutant of EndoS2 includes coupling an activated oligosaccharide to a glycoprotein acceptor. The activated oligosaccharide is a glycan oxazoline.

公开(公告)号：IL293502A

公开(公告)日：2022-08-01

申请号：IL29350222

申请日：2022-06-01

Applicant: ACADEMIA SINICA ,  CHI HUEY WONG ,  CHUNG YI WU

Inventor： CHI-HUEY WONG ,  CHUNG-YI WU

IPC: F27D11/08

Abstract: Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.

公开(公告)号：IL266526D0

公开(公告)日：2019-07-31

申请号：IL26652619

申请日：2019-05-08

Applicant: CHI HUEY WONG ,  ACADEMIA SINICA ,  CHUNG YI WU

Inventor： CHI-HUEY WONG ,  CHUNG-YI WU

IPC: F27D20060101

Abstract: Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.