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公开(公告)号：IL318755A
公开(公告)日：2025-04-01
申请号：IL31875525
申请日：2025-02-02
Applicant: ACADEMIA SINICA , CHI HUEY WONG , CHE MA , HAN YI HUANG
Inventor： CHI-HUEY WONG , CHE MA , HAN-YI HUANG
IPC: A61K39/00 , A61K39/12 , A61K39/215 , A61P31/04 , A61P31/14
Abstract: The present disclosure provides a glycoengineered SARS-CoV-2 spike protein which is capable of eliciting an enhanced immune response relative to a native spike protein of SARS-CoV-2 and its variants. The glycoengineered spike protein exposes the glycosylation sites and at the same time preserves the tertiary structure of the spike protein. The present disclosure therefore provides improved immunogens, vaccines, and methods for better prevention and treatment of the emerging coronavirus infections.
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公开(公告)号：IL314125B1
公开(公告)日：2025-04-01
申请号：IL31412524
申请日：2024-07-04
Applicant: ACADEMIA SINICA , CHI HUEY WONG , CHE MA , HAN YI HUANG
Inventor： CHI-HUEY WONG , CHE MA , HAN-YI HUANG
IPC: A61K39/00 , A61K39/12 , A61K39/215 , A61P31/04 , A61P31/14
Abstract: The present disclosure provides a glycoengineered SARS-CoV-2 spike protein which is capable of eliciting an enhanced immune response relative to a native spike protein of SARS-CoV-2 and its variants. The glycoengineered spike protein exposes the glycosylation sites and at the same time preserves the tertiary structure of the spike protein. The present disclosure therefore provides improved immunogens, vaccines, and methods for better prevention and treatment of the emerging coronavirus infections.
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公开(公告)号：BR112022022558A2
公开(公告)日：2022-12-13
申请号：BR112022022558
申请日：2021-05-07
Applicant: ACADEMIA SINICA
Inventor： CHI-HUEY WONG , HSIN-YU LIAO , SHIH-CHI WANG , YI-AN KO , KUO-I LIN , CHE MA , TING-JEN CHENG
IPC: A61K38/16 , A61K39/155 , C12N7/04
Abstract: POLIPEPTÍDEO DE HEMAGLUTININA (HA) DO VÍRUS INFLUENZA QUIMÉRICO, COMPOSIÇÃO IMUNOGÊNICA, MÉTODO DE IMUNIZAÇÃO DE UM INDIVÍDUO CONTRA O VÍRUS INFLUENZA OU PREVENÇÃO DE UMA DOENÇA DO VÍRUS INFLUENZA, POLINUCLEOTÍDEO RECOMBINANTE, VETOR E CÉLULA HOSPEDEIRA. A presente descrição refere-se a um polipeptídeo de hemaglutinina (HA) do vírus influenza quimérico, compreendendo uma ou mais sequências de domínio tronco, cada uma tendo pelo menos 60% de homologia com uma sequência consenso de domínio tronco do subtipo H1 HA (H1 HA) e/ou subtipo H5 HA (H5 HA), fundido com uma ou mais sequências de domínio de cabeça globular, cada uma tendo pelo menos 60% de homologia com uma sequência de consenso de domínio de cabeça globular do subtipo H1 HA (H1 HA) ou subtipo H5 HA (H5 HA).
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公开(公告)号：IL248607D0
公开(公告)日：2016-12-29
申请号：IL24860716
申请日：2016-10-30
Applicant: ACADEMIA SINICA , CHI-HUEY WONG , JUINE-RUEY CHEN , CHE MA , CHENG-CHI WANG
Inventor： CHI-HUEY WONG , JUINE-RUEY CHEN , CHE MA , CHENG-CHI WANG
IPC: A61K20060101
Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.
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公开(公告)号：AU2010229675A1
公开(公告)日：2011-10-27
申请号：AU2010229675
申请日：2010-03-26
Applicant: ACADEMIA SINICA
Inventor： CHI-HUEY WONG , CHE MA , CHENG-CHI WANG , JUINE-RUEY CHEN
IPC: C07K14/11 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K39/29 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , C07K14/135 , C07K14/155 , C07K14/18 , C12P21/02
Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.
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Patent Agency Ranking
公开(公告)号：IL264873B2
公开(公告)日：2023-08-01
申请号：IL26487319
申请日：2019-02-17
Applicant: CHO PHARMA INC , ACADEMIA SINICA , LIN NAN HORNG , LIN YA HUANG , SACHIN S SHIVATARE , LI TZU CHEN , CHI HUEY WONG , CHUNG YI WU , TING CHENG
Inventor： LIN NAN-HORNG , LIN-YA HUANG , SACHIN S SHIVATARE , LI-TZU CHEN , CHI-HUEY WONG , CHUNG-YI WU , TING CHENG
Abstract: A mutant of EndoS2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO:1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of EndoS2 has a low hydrolyzing activity and a high tranglycosylation activity, as compared to those of the wild-type EndoS2. A method for preparing an engineered glycoprotein using the mutant of EndoS2 includes coupling an activated oligosaccharide to a glycoprotein acceptor. The activated oligosaccharide is a glycan oxazoline.
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公开(公告)号：IL293502A
公开(公告)日：2022-08-01
申请号：IL29350222
申请日：2022-06-01
Applicant: ACADEMIA SINICA , CHI HUEY WONG , CHUNG YI WU
Inventor： CHI-HUEY WONG , CHUNG-YI WU
IPC: F27D11/08
Abstract: Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.
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公开(公告)号：IL266526D0
公开(公告)日：2019-07-31
申请号：IL26652619
申请日：2019-05-08
Applicant: CHI HUEY WONG , ACADEMIA SINICA , CHUNG YI WU
Inventor： CHI-HUEY WONG , CHUNG-YI WU
IPC: F27D20060101
Abstract: Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.
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公开(公告)号：IL226143A
公开(公告)日：2020-04-30
申请号：IL22614313
申请日：2013-05-02
Applicant: ACADEMIA SINICA , CHI HUEY WONG , CHE MA , YUNG CHIEH TSENG
Inventor： CHI-HUEY WONG , CHE MA , YUNG-CHIEH TSENG
Abstract: Methods for producing virus particles and viral antigens with simplified glycosylation profiles, such as mono-glycosylated forms of HIV, HCV, Dengue virus, West Nile virus and influenza virus. When used as targets for vaccine production, the conserved nature of such sites generate vaccines that are less sensitive to viral mutations. Such methods may include the use of glycosylation inhibitors for production of viruses or viral antigens with simplified glycosylation profiles.
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10.发明专利
公开(公告)号：MX2013004996A
公开(公告)日：2014-02-27
申请号：MX2013004996
申请日：2011-11-04
Applicant: ACADEMIA SINICA
Inventor： CHI-HUEY WONG , CHE MA , YUNG-CHIEH TSENG
Abstract: Se proporcionan métodos para producción de partículas de virus con glucosilación simplificada en proteínas estructurales o de superficie. Cuando se utilizan como objetivos para producción de vacunas, la naturaleza conservada de dichos sitios genera vacunas que son más sensibles a mutaciones víricas. Se describe el uso de inhibidores de glucosilación para producción de virus con perfiles de glucosilación simplificados. Se proporciona una descripción de ejemplo de los virus de la influenza y métodos para producción de partículas de virus de influenza monoglucosilada. Se proporcionan métodos para producción de formas monoglucosiladas de virus de influenza A, NIBRG-14 (H5N1).
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