公开(公告)号：IL286492D0

公开(公告)日：2021-12-01

申请号：IL28649221

申请日：2021-09-19

Applicant: ACADEMIA SINICA ,  WONG CHI HUEY ,  LO HONG JAY

Inventor： WONG CHI-HUEY ,  LO HONG-JAY

IPC: A61P35/00 ,  C07H15/18 ,  C07K16/28 ,  C07K16/32

Abstract: Disclosed are a method of preparing a saccharide that contains a 3-fluoro-sialic acid and a method of bonding it to a homogeneous antibody. Also within the scope of this invention are compounds each containing a 3-fluoro-sialic acid, monoclonal antibodies bonded to α2,6-linked 3-fluoro-sialoside terminated N-glycans, and treatment of cancer with such monoclonal antibodies.

公开(公告)号：CA3131096A1

公开(公告)日：2020-10-08

申请号：CA3131096

申请日：2020-03-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  LO HONG-JAY

IPC: C07H3/02 ,  C07K16/30

Abstract: Disclosed are a method of preparing a saccharide that contains a 3-fluoro-sialic acid and a method of bonding it to a homogeneous antibody. Also within the scope of this invention are compounds each containing a 3-fluoro-sialic acid, monoclonal antibodies bonded to ?2,6-linked 3-fluoro-sialoside terminated N-glycans, and treatment of cancer with such monoclonal antibodies.