公开(公告)号：AU2020397821A1

公开(公告)日：2022-06-23

申请号：AU2020397821

申请日：2020-11-15

Applicant: ACADEMIA SINICA

Inventor： YANG WEN-CHIN ,  TSAI KENG-CHANG

IPC: A61K31/7028 ,  A61K45/06 ,  G01N33/68

Abstract: Disulfide-Isomerase A4 (PDIA4) inhibitors and use thereof for inhibiting pancreatic β-cell pathogenesis and treating diabetes are disclosed. Drug candidates that inhibit PDIA4 with IC50 values ranging from 4 μM to 300 nM are identified. The compounds are highly active in augmenting insulin secretion from pancreatic β-cells. The representative compound No. 8 (4,5-dimethoxy-2-propiolamidobenzoic acid), alone or in combination with metformin, is effective in preserving pancreatic β-cell function, treating and/or reversing, returning blood glucose concentration to a normal level in a diabetic.

公开(公告)号：WO2011019827A9

公开(公告)日：2011-06-09

申请号：PCT/US2010045184

申请日：2010-08-11

Applicant: ACADEMIA SINICA ,  YANG AN-SUEI ,  LEE YU-CHING ,  CHEN ING-CHIEN ,  YU CHUNG-MING ,  HSU HUNG-JU ,  HUANG YI-JEN ,  CHANG HUNG-JU ,  TSAI KENG-CHANG ,  PENG HUNG-PIN

Inventor： YANG AN-SUEI ,  LEE YU-CHING ,  CHEN ING-CHIEN ,  YU CHUNG-MING ,  HSU HUNG-JU ,  HUANG YI-JEN ,  CHANG HUNG-JU ,  TSAI KENG-CHANG ,  PENG HUNG-PIN

IPC: C12P21/06

CPC classification number: C07K16/005 ,  C07K16/1018 ,  C07K16/22 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2319/02 ,  C12N15/1037 ,  C12N15/1051 ,  C12N15/73 ,  C12N2795/00022 ,  C40B40/08 ,  C40B50/06

Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.