公开(公告)号：ES2438518T3

公开(公告)日：2014-01-17

申请号：ES11176167

申请日：2008-02-11

Applicant: ACADEMIA SINICA

Inventor： YANG WEN-CHIN ,  CHANG LEE-TIAN

IPC: A61K31/7034 ,  A61K36/28 ,  A61P3/10

Abstract: Un extracto de Bidens pilosa que comprende una cantidad eficaz de un compuesto de la siguiente fórmula: para usar en el tratamiento de la diabetes tipo II en un sujeto que lo necesita, en donde R1 es H, C1-C10 alquilo, C2-C10 alquenilo, C2-C10 alquinilo, C3-C20 cicloalquilo, C3-C20 cicloalquenilo, C1-C20heterocicloalquilo, C1-C20 heterocicloalquenilo, arilo, o heteroarilo; R2 es H o un residuo de monosacárido; R3 es H o C1-C10 alquilo; m es 2, 3, o 4; o es 0, 1,2, 3, o 4; y p es 1, 2, 3, o 4.

公开(公告)号：AU2020397821A1

公开(公告)日：2022-06-23

申请号：AU2020397821

申请日：2020-11-15

Applicant: ACADEMIA SINICA

Inventor： YANG WEN-CHIN ,  TSAI KENG-CHANG

IPC: A61K31/7028 ,  A61K45/06 ,  G01N33/68

Abstract: Disulfide-Isomerase A4 (PDIA4) inhibitors and use thereof for inhibiting pancreatic β-cell pathogenesis and treating diabetes are disclosed. Drug candidates that inhibit PDIA4 with IC50 values ranging from 4 μM to 300 nM are identified. The compounds are highly active in augmenting insulin secretion from pancreatic β-cells. The representative compound No. 8 (4,5-dimethoxy-2-propiolamidobenzoic acid), alone or in combination with metformin, is effective in preserving pancreatic β-cell function, treating and/or reversing, returning blood glucose concentration to a normal level in a diabetic.

公开(公告)号：WO2013074273A8

公开(公告)日：2013-06-20

申请号：PCT/US2012062322

申请日：2012-10-27

Applicant: ACADEMIA SINICA ,  LIANG CHI MING

Inventor： YANG WEN-CHIN ,  CHANG LEE-TIAN

IPC: A61K36/00 ,  A01N25/08

CPC classification number: A61K31/7028 ,  A23K10/30 ,  A23K20/00 ,  A23K20/10 ,  A23K20/163 ,  A23K20/195 ,  A23K50/70 ,  A23K50/75 ,  A23K50/80 ,  A23V2002/00 ,  A23V2200/32 ,  A61K36/00 ,  A61K36/28

Abstract: A composition for use in prevention, inhibition and/or treatment of coccidiosis in an animal is disclosed. The composition comprises an effective amount of Bidens pilosa, an active constituent thereof, or an active compound isolated therefrom. In another aspect, a composition for use in preventing and/or treating coccidiosis, and/or enhancing growth in an animal is disclosed, the composition comprising an animal feed and an effective amount of Bidens pilosa, or an isolated active constituent comprising a polyacetylenic compound.

Abstract translation: 公开了用于预防，抑制和/或治疗动物体内球虫病的组合物。 该组合物包含有效量的双歧杆菌，其活性成分或由其分离的活性化合物。 另一方面，公开了用于预防和/或治疗球虫病和/或增强动物生长的组合物，所述组合物包含动物饲料和有效量的双歧杆菌（Bidens pilosa），或包含聚炔化合物的分离的活性成分 。

公开(公告)号：BR112022001074A2

公开(公告)日：2022-03-15

申请号：BR112022001074

申请日：2020-07-18

Applicant: ACADEMIA SINICA

Inventor： YANG WEN-CHIN

IPC: A61K31/7028 ,  A23K20/195 ,  A61K36/28

Abstract: formulações fitogênicas anticoccidianas. a presente invenção se refere a formulações fitogênicas anticoccidianas. especificamente, composições anticoccidiana e uso das mesmas são divulgados. uma composição anticoccidiana compreende (a) uma quantidade eficaz de extrato de artemisia indica; e (b) uma quantidade eficaz de extrato de bidens pilosa. a composição pode compreender ainda um veículo, excipiente ou portador farmaceuticamente aceitável e/ou uma ração animal. as composições anticoccidianas podem ser usadas na fabricação de um medicamento para matar oocistos coccídeos, inibir a esporulação de oocistos, reduzir a invasão de esporozoítos e diminuir as fezes sanguinolentas, ou para aliviar ou tratar a coccidiose, em um sujeito em necessidade do mesmo. em um outro aspecto, a invenção se refere ao uso de uma formulação anticoccidiana compreendendo uma quantidade eficaz de extrato de artemisia indica e um veículo farmaceuticamente aceitável na fabricação de um medicamento para matar oocistos coccídeos e inibir a esporulação de oocistos coccídeos e a invasão de esporozoítos.

公开(公告)号：AT530186T

公开(公告)日：2011-11-15

申请号：AT08101484

申请日：2008-02-11

Applicant: ACADEMIA SINICA

Inventor： YANG WEN-CHIN ,  CHANG LEE-TIAN

IPC: A61K31/7034 ,  A61K36/28 ,  A61P3/10

Abstract: This invention relates to a method of treating type II diabetes with a polyacetylenic compound of the following formula: in which R 1 is H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 ) alkynyl, C 3 -C 20 cycloalkyl, C 3 -C 20 cycloalkenyl, C 1 -C 20 heterocycloalkyl, C 1 -C 20 heterocycloalkenyl, aryl, or heteroaryl; R 2 is H or a monosaccharide residue; R 3 is H or C 1 -C 10 alkyl; m is 2, 3, or 4; n is 0, 1, 2, or 3; o is 0,1, 2, 3, or 4; and p is 1, 2, 3, or 4.

公开(公告)号：WO2015157476A3

公开(公告)日：2015-12-03

申请号：PCT/US2015025015

申请日：2015-04-09

Applicant: ACADEMIA SINICA ,  LIANG CHI MING

Inventor： YANG WEN-CHIN ,  CHANG LEE-TIAN ,  HUANG SHOU-HSIEN

IPC: A61K31/7036 ,  A61K31/7028

CPC classification number: A61K31/7028 ,  A61K31/155 ,  A61K31/216 ,  A61K31/235 ,  A61K31/341 ,  A61K31/4439 ,  A61K31/58 ,  A61K31/7105 ,  A61K38/43 ,  A61K45/06 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/30 ,  G01N33/6893 ,  G01N2333/99 ,  G01N2500/04 ,  G01N2800/042

Abstract: A Pdia4 inhibitor for use in preventing, alleviating and/or treating diabetes and/or diabetes-related complications in a subject in need thereof is disclosed, wherein the Pdia4 inhibitor does not comprise cytopiloyene. A Pdia4 inhibitor and one other anti-diabetic agent for use in combination therapy in preventing, alleviating, treating diabetes and diabetes-related complications, and/or reversing diabetes in a subject in need thereof is also disclosed, wherein the Pdia4 inhibitors for use in combination therapy may comprise cytopiloyene. Also disclosed are methods for diagnosing, treating and monitoring diabetes, and methods of screening for a Pdia4 inhibitor and/or an anti-diabetic agent.

Abstract translation: 公开了用于预防，减轻和/或治疗有需要的受试者的糖尿病和/或糖尿病相关并发症的Pdia4抑制剂，其中Pdia4抑制剂不包含细胞滴定板。 还公开了用于预防，缓解，治疗糖尿病和糖尿病相关并发症和/或逆转有需要的受试者的糖尿病的联合治疗中的Pdia4抑制剂和一种其它抗糖尿病药物，其中所述Pdia4抑制剂用于 联合治疗可能包括细胞色素 还公开了用于诊断，治疗和监测糖尿病的方法，以及筛选Pdia4抑制剂和/或抗糖尿病药的方法。