公开(公告)号：AU2014203008B2

公开(公告)日：2016-03-31

申请号：AU2014203008

申请日：2014-06-03

Applicant: ACADEMIA SINICA

Inventor： CHANG TSEWEN ,  CHEN JIUN-BO ,  WU PHEIDIAS ,  HUNG ALFUR F

IPC: C07K16/28 ,  A61K38/10 ,  A61K39/395 ,  A61P37/00

Abstract: ANTI-CEmX ANTIBODIES CAPABLE OF BINDING TO HUMAN mIgE ON B LYMPHOCYTES Abstract The invention pertains to the generation and utility of antibodies that can bind effectively to CEmX domain on membrane-bound IgE (mlgE) expressed on the surface of human B lymphocytes. The CEmX domain of 52 amino acid residues, located between the CH4 domain and the C-terminal membrane-anchor peptide on human membrane-bound epsilon chain, had been suggested as an antigenic site for immunological targeting of B cells expressing mlgE. Previous reported monoclonal antibodies, including a20, which bind to RADWPGPP peptide at the C-terminal of CEmX, have now been found to bind poorly to mlgE on human B cells. We have discovered that only monoclonal antibodies specific for certain segments, such as GLAGGSAQSQRAPDRVL and HSGQQQGLPRAAGGSVPHPR, of CEmX can bind effectively to mlgE on human B cells and hence have the utility for targeting those B cells for the treatment of diseases mediated by IgE.

公开(公告)号：ES2665495T3

公开(公告)日：2018-04-26

申请号：ES10745796

申请日：2010-02-25

Applicant: ACADEMIA SINICA

Inventor： CHANG TSE WEN ,  CHEN JIUN-BO ,  WU PHEIDIAS ,  HUNG ALFUR

IPC: C07K16/28 ,  A61K38/10 ,  A61K39/395 ,  A61P37/00 ,  C07K16/42

Abstract: Un anticuerpo específico para CεmX o un fragmento del mismo, que es capaz de unirse a IgE unida a la membrana sobre linfocitos B humanos e incapaz de unirse al péptido RADWPGPP, en donde el anticuerpo o el fragmento del mismo se une a GLAGGSAQSQRAPDRVL (SEQ ID Nº: 2).

公开(公告)号：HUE036920T2

公开(公告)日：2018-08-28

申请号：HUE10745796

申请日：2010-02-25

Applicant: ACADEMIA SINICA

Inventor： CHANG TSE WEN ,  CHEN JIUN-BO ,  WU PHEIDIAS ,  HUNG ALFUR

IPC: C07K16/28 ,  A61K38/10 ,  A61P37/00 ,  C07K16/42