公开(公告)号：AU2014203008B2

公开(公告)日：2016-03-31

申请号：AU2014203008

申请日：2014-06-03

Applicant: ACADEMIA SINICA

Inventor： CHANG TSEWEN ,  CHEN JIUN-BO ,  WU PHEIDIAS ,  HUNG ALFUR F

IPC: C07K16/28 ,  A61K38/10 ,  A61K39/395 ,  A61P37/00

Abstract: ANTI-CEmX ANTIBODIES CAPABLE OF BINDING TO HUMAN mIgE ON B LYMPHOCYTES Abstract The invention pertains to the generation and utility of antibodies that can bind effectively to CEmX domain on membrane-bound IgE (mlgE) expressed on the surface of human B lymphocytes. The CEmX domain of 52 amino acid residues, located between the CH4 domain and the C-terminal membrane-anchor peptide on human membrane-bound epsilon chain, had been suggested as an antigenic site for immunological targeting of B cells expressing mlgE. Previous reported monoclonal antibodies, including a20, which bind to RADWPGPP peptide at the C-terminal of CEmX, have now been found to bind poorly to mlgE on human B cells. We have discovered that only monoclonal antibodies specific for certain segments, such as GLAGGSAQSQRAPDRVL and HSGQQQGLPRAAGGSVPHPR, of CEmX can bind effectively to mlgE on human B cells and hence have the utility for targeting those B cells for the treatment of diseases mediated by IgE.

公开(公告)号：ES2811303T3

公开(公告)日：2021-03-11

申请号：ES15810347

申请日：2015-06-16

Applicant: ACADEMIA SINICA

Inventor： CHEN JIUN-BO ,  SHIUNG YU-YU ,  CHANG TSE-WEN

IPC: C07K16/42 ,  A61P37/06

Abstract: Un anticuerpo humanizado que tiene una actividad de unión a IgE humana libre, IgE unidas a la membrana en linfocitos B e IgE unida a CD23, pero que es incapaz de unirse a IgE unida a FcεRI, en donde dicho anticuerpo humanizado comprende una región variable de cadena pesada (VH) y una región variable de cadena ligera (VL), en donde la región variable de cadena pesada (VH) comprende una secuencia de aminoácidos que es idéntica a SEQ ID NO: 2; y en donde la región variable de cadena ligera (VL) comprende una secuencia de aminoácidos que es idéntica a SEQ ID NO: 4.

公开(公告)号：CA2943588A1

公开(公告)日：2015-12-23

申请号：CA2943588

申请日：2015-06-16

Applicant: ACADEMIA SINICA

Inventor： CHEN JIUN-BO ,  SHIUNG YU-YU ,  CHANG TSE-WEN

IPC: C07K16/00 ,  A61K39/00 ,  C12P21/08

Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.

公开(公告)号：IL214836A

公开(公告)日：2015-08-31

申请号：IL21483611

申请日：2011-08-25

Applicant: ACADEMIA SINICA ,  CHANG TSEWEN ,  CHEN JIUN-BO ,  WU PHEIDIAS C ,  HUNG ALFUR F

Inventor： CHANG TSEWEN ,  CHEN JIUN-BO ,  WU PHEIDIAS C ,  HUNG ALFUR F

IPC: A61K20060101 ,  A61P20060101 ,  C07K20060101

公开(公告)号：HUE036920T2

公开(公告)日：2018-08-28

申请号：HUE10745796

申请日：2010-02-25

Applicant: ACADEMIA SINICA

Inventor： CHANG TSE WEN ,  CHEN JIUN-BO ,  WU PHEIDIAS ,  HUNG ALFUR

IPC: C07K16/28 ,  A61K38/10 ,  A61P37/00 ,  C07K16/42

公开(公告)号：DK2401300T3

公开(公告)日：2018-04-23

申请号：DK10745796

申请日：2010-02-25

Applicant: ACADEMIA SINICA

Inventor： CHANG TSEWEN ,  CHEN JIUN-BO ,  WU PHEIDIAS C ,  HUNG ALFUR F

IPC: C07K16/28 ,  A61K38/10 ,  A61K39/395 ,  A61P37/00 ,  C07K16/42

公开(公告)号：SG11201607046VA

公开(公告)日：2016-10-28

申请号：SG11201607046V

申请日：2015-06-16

Applicant: ACADEMIA SINICA

Inventor： CHEN JIUN-BO ,  SHIUNG YU-YU ,  CHANG TSE-WEN

IPC: C07K16/00 ,  A61K39/00 ,  C12P21/08

Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.

公开(公告)号：AU2010217100B2

公开(公告)日：2014-03-27

申请号：AU2010217100

申请日：2010-02-25

Applicant: ACADEMIA SINICA

Inventor： CHANG TSEWEN ,  CHEN JIUN-BO ,  WU PHEIDIAS C ,  HUNG ALFUR F

IPC: C07K16/28 ,  A61K38/10 ,  A61K39/395 ,  A61P37/00

Abstract: The invention pertains to the generation and utility of antibodies that can bind effectively to C&egr;mX domain on membrane-bound IgE (mIgE) expressed on the surface of human B lymphocytes. The C&egr;mX domain of 52 amino acid residues, located between the CH4 domain and the C-terminal membrane-anchor peptide on human membrane-bound epsilon chain, had been suggested as an antigenic site for immunological targeting of B cells expressing mlgE. Previous reported monoclonal antibodies, including a20, which bind to RADWPGPP peptide at the C-terminal of C&egr;mX, have now been found to bind poorly to mlgE on human B cells. We have discovered that only monoclonal antibodies specific for certain segments, such as GLAGGSAQSQRAPDRVL and HSGQQQGLPRAAGGSVPHPR, of C&egr;mX can bind effectively to mlgE on human B cells and hence have the utility for targeting those B cells for the treatment of diseases mediated by IgE.

公开(公告)号：NZ723520A

公开(公告)日：2018-06-29

申请号：NZ72352015

申请日：2015-06-16

Applicant: ACADEMIA SINICA

Inventor： CHEN JIUN-BO ,  SHIUNG YU-YU ,  CHANG TSE-WEN

IPC: C07K16/00 ,  A61K39/00 ,  C12P21/08

Abstract: A humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, and IgE bound by CD23, but not to IgE bound by FcɛRI. The CDR-H1, CDR-H2 and CDR-H3 of the antibody respectively comprise the amino acid sequences of SEQ ID NOs: 5-7, and the CDR-L1, CDR-L2 and CDR-L3 of the antibody respectively comprise the amino acid sequences of SEQ ID NOs: 8-10.

公开(公告)号：AU2015277379A1

公开(公告)日：2016-09-08

申请号：AU2015277379

申请日：2015-06-16

Applicant: ACADEMIA SINICA ,  LIANG CHI MING

Inventor： CHEN JIUN-BO ,  SHIUNG YU-YU ,  CHANG TSE-WEN

IPC: C07K16/00 ,  A61K39/00 ,  C12P21/08

Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.