公开(公告)号：DE69816832T2

公开(公告)日：2004-05-27

申请号：DE69816832

申请日：1998-03-11

Applicant: ADDEX PHARMACEUTICALS S A

Inventor： FINK-JENSEN ANDERS ,  FOGED CHRISTIAN

IPC: C07D223/16 ,  A61K31/55 ,  A61P25/20 ,  C07D405/04 ,  C07H21/00

Abstract: The present invention provides novel uses of the compounds of general formula (I) wherein R3 is hydrogen, alkyl or cycloalkyl; R4 is hydrogen or R4 together with R10 represents a bridge; R7 is hydroxy or alkoxy; R10, R11, R12 independently repent hydrogen, trifluoromethyl, halogen or alkyl; or R10 together with R11 represents a bridge, or R11 together with R12 represents a bridge the bridge in both cases being chosen among -O-CH2-CH2-, -O-CH2-CH2-CH2-, -O-CH=CH-, -CH2-CH2-CH2-, -CH2-CH=CH- or -CH2-CH2-CH2-CH2-; R13 is hydrogen, halogen or alkyl; and pharmaceutically acceptable salts thereof in combination with a pharmaceutically acceptable carrier for the manufacture of a pharmaceutical composition for treatment of sleep disorders and/or sleep disturbances.

公开(公告)号：DE69816832D1

公开(公告)日：2003-09-04

申请号：DE69816832

申请日：1998-03-11

Applicant: ADDEX PHARMACEUTICALS S A

Inventor： FINK-JENSEN ANDERS ,  FOGED CHRISTIAN

IPC: C07D223/16 ,  A61K31/55 ,  A61P25/20 ,  C07D405/04 ,  C07H21/00

Abstract: The present invention provides novel uses of the compounds of general formula (I) wherein R3 is hydrogen, alkyl or cycloalkyl; R4 is hydrogen or R4 together with R10 represents a bridge; R7 is hydroxy or alkoxy; R10, R11, R12 independently repent hydrogen, trifluoromethyl, halogen or alkyl; or R10 together with R11 represents a bridge, or R11 together with R12 represents a bridge the bridge in both cases being chosen among -O-CH2-CH2-, -O-CH2-CH2-CH2-, -O-CH=CH-, -CH2-CH2-CH2-, -CH2-CH=CH- or -CH2-CH2-CH2-CH2-; R13 is hydrogen, halogen or alkyl; and pharmaceutically acceptable salts thereof in combination with a pharmaceutically acceptable carrier for the manufacture of a pharmaceutical composition for treatment of sleep disorders and/or sleep disturbances.