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    CONDUCTIVE NANOCRYSTALLINE DIAMOND MICRO-ELECTRODE SENSORS AND ARRAYS FOR IN-VIVO CHEMICAL SENSING OF NEUROTRANSMITTERS AND NEUROACTIVE SUBSTANCES AND METHOD OF FABRICATION THEREOF
    1.
    发明申请
    CONDUCTIVE NANOCRYSTALLINE DIAMOND MICRO-ELECTRODE SENSORS AND ARRAYS FOR IN-VIVO CHEMICAL SENSING OF NEUROTRANSMITTERS AND NEUROACTIVE SUBSTANCES AND METHOD OF FABRICATION THEREOF 审中-公开
    导电纳米金刚石微电极传感器和神经递质和神经活性物质的化学传感器阵列及其制备方法

    公开(公告)号：WO2014052618A1

    公开(公告)日：2014-04-03

    申请号：PCT/US2013/061958

    申请日：2013-09-26

    Applicant: ADVANCED DIAMOND TECHNOLOGIES, INC.

    Inventor： ARUMUGAM, Prabhu, U ,  SIDDIQUI, Shabnam ,  ZENG, Hongjun

    IPC: A61B5/04

    CPC classification number: A61B5/685 ,  A61B5/0048 ,  A61B5/04001 ,  A61B5/0422 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2562/125

    Abstract: Conductive diamond micro-electrode sensors and sensor arrays are disclosed for in vivo chemical sensing. Also provided is a method of fabrication of individual sensors and sensor arrays. Reliable, sensitive and selective chemical micro-sensors may be constructed for real-time, continuous monitoring of neurotransmitters and neuro-active substances in vivo . Each sensor comprises a conductive microwire, having a distal end comprising a tip, coated with nanocrystalline or ultrananocrystalline conductive diamond, and an overlying insulating layer. Active sensor areas of the conductive diamond layer are defined by openings in the insulating layer at the distal end. Multiple sensor areas may be defined by a 2 or 3 dimensional pattern of openings near the tip. This structure limits interference from surrounding areas for improved signal to noise ratio, sensitivity and selectivity. Using fast-scan cyclic voltammetry and high speed multiplexers, multiple sensors can be arrayed to provide 3-D spatial, and near real-time monitoring.

    Abstract translation: 公开了用于体内化学感测的导电金刚石微电极传感器和传感器阵列。 还提供了制造各个传感器和传感器阵列的方法。 可以构建可靠，灵敏和选择性的化学微传感器，用于体内神经递质和神经活性物质的实时连续监测。 每个传感器包括导电微线，其具有包括尖端的远端，涂覆有纳米晶体或超微晶体导电金刚石，以及覆盖绝缘层。 导电金刚石层的有源传感器区域由远端绝缘层中的开口限定。 多个传感器区域可以由尖端附近的开口的2或3维图案限定。 这种结构限制了周围区域的干扰，提高了信噪比，灵敏度和选择性。 使用快速扫描循环伏安法和高速多路复用器，可以对多个传感器进行排列，以提供3-D空间和近实时监控。

    OZONE GENERATORS, METHODS OF MAKING OZONE GENERATORS, AND METHODS OF GENERATING OZONE
    2.
    发明申请
    OZONE GENERATORS, METHODS OF MAKING OZONE GENERATORS, AND METHODS OF GENERATING OZONE 审中-公开
    臭氧发生器，制造臭氧发生器的方法以及臭氧发生方法

    公开(公告)号：WO2018075920A1

    公开(公告)日：2018-04-26

    申请号：PCT/US2017/057645

    申请日：2017-10-20

    Applicant: ADVANCED DIAMOND TECHNOLOGIES, INC.

    Inventor： ZENG, Hongjun ,  CERES, Donato M. ,  WAGNER, John

    IPC: C25B9/08 ,  C25B11/04 ,  C25B1/13 ,  C01B13/11

    Abstract: An electrolytic ozone generator includes an anode with a longitudinal edge, a cathode with a longitudinal edge spaced apart from the cathode, and an isolator. The isolator electrically separates the cathode from the anode and is semi-impermeable. The anode and cathode are impermeable for generating ozone in a flow area fluidly coupling longitudinal edges of the anode and the cathode. Ozone water apparatus, methods of making electrolytic ozone generators, and methods of generating ozone using electrolytic ozone generators are also described.

    Abstract translation: 电解臭氧发生器包括具有纵向边缘的阳极，具有与阴极隔开的纵向边缘的阴极以及隔离器。 隔离器将阴极与阳极电分离并且是半渗透性的。 阳极和阴极不可渗透以在流体区域中产生臭氧，所述流动区域流体连接阳极和阴极的纵向边缘。 还描述了臭氧水装置，制造电解臭氧发生器的方法以及使用电解臭氧发生器产生臭氧的方法。

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