公开(公告)号：JPH0399070A

公开(公告)日：1991-04-24

申请号：JP23600389

申请日：1989-09-12

Applicant: AGENCY IND SCIENCE TECHN

Inventor： OKUNO HIROAKI ,  ODAKA MASATO ,  SHIMURA TAKEHIKO ,  TOMOHIRO TAKENORI ,  RII AA RETSUKU

IPC: C07D263/22

Abstract: PURPOSE:To prepare the subject compound useful as a raw material or intermediate for drugs such as anticonvulsants by reacting an ethanolamine derivative with carbon dioxide in the presence of a photosensitizer, a thiol, a phosphine, a tertiary amine and oxygen. CONSTITUTION:An ethanolamine derivative (e.g. 3-amino-1-phenylethanol) is reacted with carbon dioxide in the presence of a tertiary amine (e.g. triethylamine) in a solvent such as acetonitrile at the room temperature, mixed with a photosensitizer [e.g. tris(2,2'-bipyridinyl)ruthenium (II) chloride], a phosphine (e.g. tri-n-butyl phosphine) and a thiol (e.g. thiphenol) and subsequently irradiated with light to provide the objective compound wherein a reaction vessel contacting with air is employed. The immobilization of the carbon dioxide permits to reduce the concentration of the carbon dioxide in the atmosphere, prevent the warming of the earth and provide substances having high additional values.

公开(公告)号：JPH0692945A

公开(公告)日：1994-04-05

申请号：JP26926792

申请日：1992-09-11

Applicant: AGENCY IND SCIENCE TECHN

Inventor： KUBOTA YASUHIKO ,  ODAKA MASATO ,  TOMOHIRO TAKENORI ,  OKUNO HIROAKI

IPC: C07D263/22 ,  C07D263/58 ,  C07D265/10 ,  C07D265/12 ,  C07D265/18

Abstract: PURPOSE:To provide the method for producing a cyclic urethane compound by reacting an aminoalcohol with carbon dioxide. CONSTITUTION:An aminoalcohol is reacted with carbon dioxide in the presence of a tertiary amine, a trivalent organic phosphorus compound and an organic halide compound to produce the cyclic urethane compound. The method can provide the cyclic urethane compound at the ordinary temperature under the ordinary pressure in a high yield. Further, the chemical fixation of the carbon dioxide and the treatment of the organic halide compound can simultaneously be performed.

公开(公告)号：JPH0472085A

公开(公告)日：1992-03-06

申请号：JP18119690

申请日：1990-07-09

Applicant: AGENCY IND SCIENCE TECHN

Inventor： TOMOHIRO TAKENORI ,  ODAKA MASATO ,  KUBOTA YASUHIKO ,  SHIMURA TAKEHIKO ,  OKUNO HIROAKI

IPC: C07C65/105 ,  C25B3/02

Abstract: PURPOSE:To produce aromatic carboxylic acid having high additional value from carbon dioxide with rather low voltage and high current efficiency by effecting the electrochemical reaction of aromatic ketone and carbon dioxide in the presence of specified cluster. CONSTITUTION:The reaction of aromatic ketone and carbon dioxide is effected on electrodes in the presence of iron-sulfur cluster expressed by formula (1) or molybdenum-iron-sulfur cluster expressed by formula (2) or (3). In the formula (1), R is phenyl group, benzyl group or tertiary butyl group, X is tetramethylammonium group or tetraethylammonium group, and n is 1, 2, 3 or 4. In the formulae (2), (3), R is phenyl group, benzyl group or ethyl group, X is same as in the formula (1), and n is 2,3,4 or 5. These clusters act as a catalyst for electron movement, and thereby, efficient reaction is possible at a low electric voltage. Thereby, carbon dioxide can be efficiently fixed, which produces aromatic carboxylic acid.

公开(公告)号：JPS61291779A

公开(公告)日：1986-12-22

申请号：JP13377385

申请日：1985-06-19

Applicant: AGENCY IND SCIENCE TECHN

Inventor： FUKAYA TOSHIO ,  ODAKA MASATO

IPC: F03G7/00

Abstract: PURPOSE:To utilize effectively energy by producing differential pressure between gas components through a gas selecting permeable material and converting this differential pressure to energy easy to utilize. CONSTITUTION:An upper portion of a container 1 is constituted from a gas selecting permeable material 2 like polyimide resin film reinforced with a perforated glass for example. This container 1 is disposed in the atmosphere which makes the gas selecting permeable material 2 less permeable, and gas component GA such as permeable carbon dioxide, herium, neon, is enclosed in the container 1. this gas component GA permeates through said material 2 to produce differential pressure between the atmosphere and the interior of the container 1 to pump up water into the container 1 through a pipe with this differential pressure.

公开(公告)号：JPH04108796A

公开(公告)日：1992-04-09

申请号：JP22611190

申请日：1990-08-28

Applicant: AGENCY IND SCIENCE TECHN

Inventor： OKUNO HIROAKI ,  SHIMURA TAKEHIKO ,  TOMOHIRO TAKENORI ,  OKADA TOMOKO ,  ODAKA MASATO

IPC: A61K31/28 ,  A61K31/282 ,  A61K31/555 ,  A61K31/70 ,  A61K31/7135 ,  A61P35/00 ,  C07C211/09 ,  C07C211/36 ,  C07D239/54 ,  C07D239/553 ,  C07F9/6558 ,  C07F15/00 ,  C07H23/00

Abstract: PURPOSE:To obtain the subject complex useful as a medical drug having an antitumor activity by a ready method in high yield by reacting a specific compound with uridine, etc., in the presence of a silver salt and an oxidizing agent. CONSTITUTION:A compound expressed by formula I [X is Cl or I; Y is NH3, CnH2n+1NH2 (n=1-12), NH2-CmH2mNH2 ((m) is 2-10) or expressed by formula II] is reacted with uridine, thymidine, uracil, thymine, 2'-deoxyuridine, uridine-5'- monophosphate, 5-fluorouracil or 1,2-diaminocyclohexane in the presence of a silver salt and an oxidizing agent to afford the aimed complex. Besides, number of platinum atoms in the molecule is preferably 6-15.

公开(公告)号：JPH04112879A

公开(公告)日：1992-04-14

申请号：JP23128190

申请日：1990-08-31

Applicant: AGENCY IND SCIENCE TECHN

Inventor： ODAKA MASATO ,  TOMOHIRO TAKENORI ,  KUBOTA YASUHIKO ,  SHIMURA TAKEHIKO ,  OKUNO HIROAKI

IPC: C07D263/20 ,  B01J31/22 ,  C01G49/12 ,  C07B61/00 ,  C07D263/22

Abstract: PURPOSE:To obtain the title compound using a reagent having low toxicity at ordinary temperature and pressure by reacting a specific ethanolamine derivative with carbon dioxide in the presence of an iron-sulfur complex, aromatic thiol, triphenylphosphine and oxygen. CONSTITUTION:An ethanolamine derivative (e.g. 2-amino-1-phenylethanol) expressed by formula II [R and R are H, (substituted) lower alkyl or (substituted) phenyl] is reacted with carbon dioxide in the presence of an iron- sulfur complex expressed by formula I, aromatic thiol (e.g. 2-mercaptopyridine), triphenylphosphine and oxygen to provide the aimed compound expressed by formula III Furthermore, the above-mentioned reaction is further preferably carried out in the presence of a tert. amine (e.g. triethylamine).