公开(公告)号：JPH11124360A

公开(公告)日：1999-05-11

申请号：JP28493497

申请日：1997-10-17

Applicant: AGENCY IND SCIENCE TECHN

Inventor： KISHI RYOICHI ,  ICHIJO HISAO ,  SHINPO TOSHIO ,  SATO TAKAO ,  YOSOMIYA RYUTOKU ,  OGINO KAZUYOSHI

IPC: C07C233/49 ,  C07C271/22 ,  C08F20/60

Abstract: PROBLEM TO BE SOLVED: To obtain a new compound usable for copolymerization of a high molecular weight compound having an usage such as heat-sensitively responsible polymer by carrying out protection of the hydrogen atom of the amino group bonding to the α-carbon of an amino acid and the hydroxy group of the carboxyl group with a protecting group. SOLUTION: This compound is the one of formula I (Z is a protecting group of H of amino group; Y is the protecting group of hydroxy group of carboxyl group), e.g. a compound of formula II (Z is formula III; Bz1 is formula IV). The compound of formula I is obtained, for example, by dissolving a compound of formula V [Boc is (CH3 )3 COCO], dimethylaminopyridine and benzyl alcohol in methylene chloride, adding a water-soluble carbodiimide-hydrochloride to the methylene chloride solution to react, dropping 4N hydrochloric acid/ethyl acetate solution to the compound obtained by the reaction, dissolving the obtained product and triethylamine in tetrahydrofuran and, by adding acryloyl chloride to the tetrahydrofuran solution to react with the dissolved compound to provide the objective compound of formula II.

公开(公告)号：JPH11116639A

公开(公告)日：1999-04-27

申请号：JP28495097

申请日：1997-10-17

Applicant: AGENCY IND SCIENCE TECHN

Inventor： KISHI RYOICHI ,  ICHIJO HISAO ,  SHINPO TOSHIO ,  SATO TAKAO ,  YOSOMIYA RYUTOKU ,  OGINO KAZUYOSHI

IPC: C07B57/00 ,  C08F220/56 ,  C08F220/60

Abstract: PROBLEM TO BE SOLVED: To obtain the subject copolymer that has further higher transition point and can manifest the functions of recognition of amino acids and optical resolution by copolymerizing a monomer bearing an amino acid residue on its side chain and an N-isopropylacrylamide. SOLUTION: This copolymer is represented by formula I ((m), (n) are each the proportion in weight% of individual components in the copolymer) and is obtained by copolymerizing a compound of formula II (Z is a protecting group for H atom in an amino group; Y is a protecting group for hydroxyl in a carboxyl group, for example, benzyl and the like; protecting group Z is benzyloxycarbonyl, t-butoxy-carbonyl) with N-isopropylacrylamide followed by deprotection of the protecting groups Z and Y. This copolymer is dissolved in water at a lower temperature than the transition point, but causes a phase separation above the transition point and the aqueous solution becomes cloudy, thus it can be expectedly used as a thermally responding polymer. In addition, the copolymer can also be used as a reagent for discrimination of kinds of amino acids and for resolution of amino acids.