公开(公告)号：DE19909567B4

公开(公告)日：2006-01-19

申请号：DE19909567

申请日：1999-03-04

Applicant: AGILENT TECHNOLOGIES INC

Inventor： MAUZE GANAPATI R ,  GREENSTEIN MICHAEL ,  VERDONK EDWARD D ,  LUM PAUL

IPC: A61B5/151 ,  A61B5/15 ,  A61B10/00 ,  A61B10/02 ,  A61B17/32 ,  A61B17/34

Abstract: A multi-shaft apparatus for incising a substrate of soft resilient material such as a body tissue. The incising apparatus includes two or more incision shafts each having a distal edge. The shafts are not affixed to each other and are allowed to slide against each other to drive the distal edges alternately against the substrate to incise the substrate. In the case of incising a body tissue, such alternate motion would result in less pain to the patient than a puncture resulting from a sharp jab by a sharp shaft of similar size to the shafts.

公开(公告)号：WO2005045392A3

公开(公告)日：2006-01-19

申请号：PCT/US2004026959

申请日：2004-08-18

Applicant: AGILENT TECHNOLOGIES INC

Inventor： PITTARO RICHARD J ,  VERDONK EDWARD D ,  DOHERTY THOMAS P

IPC: B01L3/00 ,  G01N21/64 ,  G01N33/542 ,  G01N33/68 ,  C12Q1/68

CPC classification number: G01N21/6428 ,  B01L3/5027 ,  B82Y15/00 ,  G01N33/48721 ,  G01N33/542 ,  G01N33/6803 ,  G01N2021/6432

Abstract: The present invention provides an apparatus for detecting a nanoscale moiety and a method for sensing a nanoscale moiety. The apparatus includes a substrate having a nanopore, at least one excitable molecule attached to the substrate adjacent to the nanopore, and a light source for exciting the excitable molecule attached to the substrate adjacent to the nanopore wherein the excitable molecule is quenched by the quencher molecule on the nanoscale moiety as it passes by the excitable molecule. The invention also includes a method for detecting the presence or identity of the nanoscale moiety.

Abstract translation: 本发明提供了一种用于检测纳米尺度部分的装置和用于感测纳米尺度部分的方法。 该装置包括具有纳米孔的底物，与纳米孔相邻的至少一个可附着到基底上的可激发分子，以及用于激发附着于邻近纳米孔的底物的可激发分子的光源，其中可激发分子被猝灭剂分子淬灭 在纳米级部分通过可兴奋分子时。 本发明还包括用于检测纳米尺度部分的存在或身份的方法。