公开(公告)号：JP2009180731A

公开(公告)日：2009-08-13

申请号：JP2009019968

申请日：2009-01-30

Applicant: Agilent Technol Inc ,  アジレント・テクノロジーズ・インクAgilent Technologies, Inc.

Inventor： DOHERTY THOMAS P ,  KERNAN JEFFREY T ,  FOOTE JAMES D

IPC: G01N27/62

CPC classification number: H01J49/0045

Abstract: PROBLEM TO BE SOLVED: To reduce the number of metastable state atoms (molecules) of a carrier gas in a mass spectrometer, and also reduce a noise in a mass analysis. SOLUTION: A method for reducing noise in mass analysis includes: a step of ionizing a sample so as to generate ions of a specimen within the sample in the mass spectrometer; a step of separating the generated ions by a mass-charge ratio; a step of detecting the separated ions by a detector; and a step of introducing the gas in which the metastable state atoms (molecules) are reduced. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：为了减少质谱仪中载气的亚稳状态原子（分子）的数量，并且还减少质量分析中的噪声。 解决方案：用于降低质量分析中的噪声的方法包括：使样品电离以在质谱仪中产生样品内样品的离子的步骤; 通过质量充电比分离产生的离子的步骤; 通过检测器检测分离的离子的步骤; 以及引入其中亚稳态原子（分子）还原的气​​体的步骤。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：GB2379080B

公开(公告)日：2005-05-11

申请号：GB0207112

申请日：2002-03-26

Applicant: AGILENT TECHNOLOGIES INC

Inventor： YIN HONGFENG ,  DOHERTY THOMAS P ,  SWEDBURG SALLY A

IPC: H01J49/04

Abstract: The present invention relates to microdevices for introducing a small volume of a fluid sample into an ionization chamber. The microdevices are constructed from a substrate having a first and second opposing surfaces, the substrate having a microchannel formed in the first surface, and a cover plate arranged over the first surface, the cover plate in combination with the microchannel defining a conduit for conveying the sample. A sample inlet port is provided in fluid communication with the microchannel, wherein the sample inlet port allows the fluid sample from an external source to be conveyed in a defined sample flow path that travels, in order, through the sample inlet port, the conduit and a sample outlet port and into the ionization chamber. Optionally, the fluid sample undergoes a chemical or biochemical reaction within an integrated portion of the microdevice before reaching the ionization chamber. A nebulizing means nebulizes the fluid sample in a nebulizing region adjacent to the sample outlet port. The invention also relates to a method for introducing a fluid sample using the microdevice.

公开(公告)号：GB2379080A

公开(公告)日：2003-02-26

申请号：GB0207112

申请日：2002-03-26

Applicant: AGILENT TECHNOLOGIES INC

Inventor： YIN HONGFENG ,  DOHERTY THOMAS P ,  SWEDBURG SALLY A

IPC: H01J49/04

Abstract: A microfabricated device 30 for introducing a small volume of a fluid sample into the ionization chamber of an inductively coupled plasma mass spectrometer (ICP-MS) is constructed from a substrate 32 having first 34 and second 36 opposing surfaces. A microchannel 38 formed in the first surface 34 and a cover plate 50 arranged over the first surface 34 define a conduit for conveying the sample. A sample inlet port 54 in fluid communication with micro-channel 38 allows the fluid sample from an external source to be conveyed in a defined flow path through the conduit and a sample outlet port 56 into the ionisation chamber. Optionally, the sample undergoes a chemical or biochemical reaction within the microdevice before reaching the ionisation chamber. A nebulizing means 58 nebulises the fluid sample in a region adjacent to the outlet port.

公开(公告)号：WO2005045392A3

公开(公告)日：2006-01-19

申请号：PCT/US2004026959

申请日：2004-08-18

Applicant: AGILENT TECHNOLOGIES INC

Inventor： PITTARO RICHARD J ,  VERDONK EDWARD D ,  DOHERTY THOMAS P

IPC: B01L3/00 ,  G01N21/64 ,  G01N33/542 ,  G01N33/68 ,  C12Q1/68

CPC classification number: G01N21/6428 ,  B01L3/5027 ,  B82Y15/00 ,  G01N33/48721 ,  G01N33/542 ,  G01N33/6803 ,  G01N2021/6432

Abstract: The present invention provides an apparatus for detecting a nanoscale moiety and a method for sensing a nanoscale moiety. The apparatus includes a substrate having a nanopore, at least one excitable molecule attached to the substrate adjacent to the nanopore, and a light source for exciting the excitable molecule attached to the substrate adjacent to the nanopore wherein the excitable molecule is quenched by the quencher molecule on the nanoscale moiety as it passes by the excitable molecule. The invention also includes a method for detecting the presence or identity of the nanoscale moiety.

Abstract translation: 本发明提供了一种用于检测纳米尺度部分的装置和用于感测纳米尺度部分的方法。 该装置包括具有纳米孔的底物，与纳米孔相邻的至少一个可附着到基底上的可激发分子，以及用于激发附着于邻近纳米孔的底物的可激发分子的光源，其中可激发分子被猝灭剂分子淬灭 在纳米级部分通过可兴奋分子时。 本发明还包括用于检测纳米尺度部分的存在或身份的方法。