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公开(公告)号：JP2005135916A
公开(公告)日：2005-05-26
申请号：JP2004315861
申请日：2004-10-29
Inventor： LI GANGGIANG , GOODLEY PAUL C , YIN HONGFENG
CPC classification number: H01J49/167
Abstract: PROBLEM TO BE SOLVED: To improve a function of an electro spray device disposed so that a spray needle and an ion extraction interface become orthogonal to each other.
SOLUTION: An interface axis 122 is disposed in a relationship so as to cross a spray nozzle axis 124, an angle defined between the nozzle axis 124 and the interface axis 122 are set from around 75 ° and around 105 °. An interface 106 is possible to operate to accept a voltage from an interface power source, and an auxiliary electrode 140 can operate for accepting a voltage from an auxiliary power source. The electrode 140 can operate, to regulate electric field at an outlet orifice and disposed in a relationship possible to operate against the orifice. The electro spray device can operate to define an ion passage, through which ions on their ways from the orifice to an inlet are passed and the electrode 140 is disposed outside the ion passage.
COPYRIGHT: (C)2005,JPO&NCIPIAbstract translation: 要解决的问题：为了改善布置成使得喷针和离子提取界面彼此正交的电喷装置的功能。 解决方案：接口轴线122以与喷嘴轴线124交叉的关系设置，在喷嘴轴线124和界面轴线122之间限定的角度设定为大约75°和大约105°。 接口106可以操作以接受来自接口电源的电压，并且辅助电极140可以操作以接受来自辅助电源的电压。 电极140可以操作以调节出口孔处的电场并且以关于孔的作用的关系设置。 电喷雾装置可以操作以限定离子通道，通过离子通道离开通道，通过该离子通道从孔口到入口的离子通过，电极140设置在离子通道的外部。 版权所有（C）2005，JPO＆NCIPI
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公开(公告)号：JP2006276021A
公开(公告)日：2006-10-12
申请号：JP2006091679
申请日：2006-03-29
Inventor： KILLEEN KEVIN P , YIN HONGFENG , KRAICZEK KARSTEN G
CPC classification number: G01N30/10 , G01N30/20 , G01N30/34 , G01N30/6095 , G01N2030/201 , G01N2030/202 , G01N2030/385
Abstract: PROBLEM TO BE SOLVED: To provide an improved microflow control system for reducing delay time in gradient high-speed liquid chromatography. SOLUTION: In this method, a device, which includes a mechanism for optionally diverting a part of mobile phase, flowing through a mobile phase transport pipe, into a liquid transport pipe containing stationary phase to separate sample components, is used. This device is equipped with the liquid transport pipe, containing stationary phase communicated with at least one mobile phase transport pipe which includes the mechanism for optionally diverting a part of mobile phase flowing through the mobile phase transport pipe, and the remainder of the mobile phase flows into the liquid transport pipe containing the stationary phase. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：提供改进的微流控制系统，用于减少梯度高速液相色谱中的延迟时间。 解决方案：在该方法中，使用包括用于将流过流动相输送管的流动相的一部分转移到含有固定相的液体输送管中以分离样品组分的机构的装置。 该装置配备有液体输送管，其包含与至少一个流动相输送管连通的固定相，其包括用于可选地转移流过流动相输送管的流动相的一部分的机构，以及流动相流的其余部分 进入含有固定相的液体输送管。 版权所有（C）2007，JPO＆INPIT
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3.发明专利Device and method using fluid-transporting feature of differing dwell time 审中-公开使用不同时间的流体传输特征的装置和方法
公开(公告)号：JP2007139782A
公开(公告)日：2007-06-07
申请号：JP2006312863
申请日：2006-11-20
Inventor： BRENNEN REID , YIN HONGFENG , KILLEEN KEVIN , SCHLEIFER ARTHUR
CPC classification number: G01N30/34 , B01F13/0059 , B01F13/0094 , B01L3/502746 , B01L2300/0867 , B01L2400/0418 , B01L2400/0487 , B01L2400/084 , Y10T137/2224
Abstract: PROBLEM TO BE SOLVED: To provide an improved fluid technology which is capable of using gradient liquid chromatography and reducing the amount of waste liquid, free of complications, has reproducibility, and shortens the delay time. SOLUTION: A fluidic device is provided with a plurality of fluid-transporting features, extending from a common inlet to a common outlet, and a means for effecting a fluid flow through the fluid-transporting features. Each feature has a differing fluid dwell time. The means for effecting a fluid flow cooperates with the fluid-transporting features, merges fluids from the fluid-transporting features, and produces an output stream from the common outlet. The output stream exhibits at least one desired characteristic generated as the result of the differing dwell times. It is thereby possible to generate a stream of a micro-volume flow rate and to obtain a smooth gradient in gradient liquid chromatography also. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：为了提供能够使用梯度液相色谱和减少没有并发症的废液的量的改进的流体技术，具有再现性并缩短延迟时间。 解决方案：流体装置设置有从公共入口延伸到公共出口的多个流体输送特征，以及用于实现流体流过流体输送特征的装置。 每个功能都具有不同的流体停留时间。 用于实现流体流动的装置与流体输送特征协作，合并来自流体输送特征的流体，并从公共出口产生输出流。 输出流表现出由于不同停留时间而产生的至少一个期望特性。 从而可以产生微量流量的流，并且也可以在梯度液相色谱中获得平滑的梯度。 版权所有（C）2007，JPO＆INPIT
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4.发明专利Fluid device with adjacent conductive layer on inner surface and outer surface 审中-公开在内表面和外表面上具有相邻导电层的流体装置
公开(公告)号：JP2007256261A
公开(公告)日：2007-10-04
申请号：JP2007000045
申请日：2007-01-04
Inventor： FAZZIO SHANE R , KILLEEN KEVIN P , GOEL ATUL , BRENNEN REID , YIN HONGFENG
CPC classification number: G01N27/44791 , B01L3/5027 , B01L9/527 , B01L2200/027 , B01L2300/069 , B01L2300/0887 , B01L2400/0421
Abstract: PROBLEM TO BE SOLVED: To provide microfluidic device which has a configuration for enabling an easier interconnection with an analytical instrument and its forming method by using caddie. SOLUTION: This fluid device 10 includes body section 11 and adjacent conductive layer 100. The body section 11 comprises inner surface and outer surface. The inner surface demarcates well and fluid carrier feature 25 such as micro feature in which well and fluid are fluently communicating. The adjacent conductive layer 100 is located on well sidewall 46S and selected area on inner/outer surfaces, where a contact pad area is formed on the outer surface 44 as electrically-connected with an arbitrary fluid in the fluid carrier feature 25. COPYRIGHT: (C)2008,JPO&INPIT
Abstract translation: 要解决的问题：提供一种微流体装置，其具有能够更容易地与分析仪器相互连接的构造及其通过使用球童的形成方法。 解决方案：该流体装置10包括主体部分11和相邻的导电层100.主体部分11包括内表面和外表面。 内表面划分好，流体载体特征25例如微孔特征，其中井和流体是流体通信的。 相邻的导电层100位于阱侧壁46S和内/外表面上的选定区域，其中在外表面44上形成与流体载体特征25中的任意流体电连接的接触焊盘区域。 版权所有（C）2008，JPO＆INPIT
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公开(公告)号：JP2007218899A
公开(公告)日：2007-08-30
申请号：JP2006340752
申请日：2006-12-19
Inventor： YIN HONGFENG , KILLEEN KEVIN , BRENNEN REID
CPC classification number: G01N30/20 , G01N30/02 , G01N30/6095 , G01N30/7266 , G01N2030/202 , Y10T436/25 , B01D15/14
Abstract: PROBLEM TO BE SOLVED: To provide a micro fluidic separation device reduced in broadening of a band. SOLUTION: The present invention provides the fluidic separation device 10 and method capable of reducing sample broadening. A column 25 is arranged in a downstream of a holding chamber 53, and a fluid supply means provides a fluid flow effective to convey a sample along a flow passage extended from the holding chamber up to the separation column. A sample is usually converged in the flow passage in an upstream of the separation column. An electrospray mass spectrometer may be provided optionally, and may be used in microfluid application. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：提供减少带宽变宽的微流体分离装置。 解决方案：本发明提供了能够减少样品加宽的流体分离装置10和方法。 柱25布置在保持室53的下游，并且流体供应装置提供有效地沿着沿着从保持室延伸到分离塔的流动通道输送样品的流体流。 样品通常在分离塔的上游会聚在流动通道中。 可以任选地提供电喷雾质谱仪，并且可以在微流体应用中使用。 版权所有（C）2007，JPO＆INPIT
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Patent Agency Ranking
公开(公告)号：JP2006215033A
公开(公告)日：2006-08-17
申请号：JP2006026362
申请日：2006-02-02
Inventor： YIN HONGFENG , KILLEEN KEVIN P
CPC classification number: G01N30/463 , B01L3/0268 , B01L3/502738 , B01L2300/0681 , B01L2300/0816 , B01L2400/0622 , B01L2400/0644 , G01N30/7266
Abstract: PROBLEM TO BE SOLVED: To provide a technique for multi-dimensional separation of samples, which is suitably applicable to biological molecular analysis although it is easy to manufacture and simple in structure. SOLUTION: The device for separation comprises a first substrate containing a first separated fluid transport mechanism for separating molecules in a sample according to a first characteristic and a second substrate including a second separated fluid transport mechanism for separating molecules in the sample according to a second characteristic. The first and second substrates are located in different planes, and the first and second separated fluid transport mechanisms are mutually connectable by being controlled. COPYRIGHT: (C)2006,JPO&NCIPI
Abstract translation: 要解决的问题：提供一种用于样品的多维分离的技术，其适用于生物分子分析，尽管其易于制造并且结构简单。 解决方案：用于分离的装置包括含有第一分离的流体输送机构的第一基材，所述第一分离的流体输送机构用于根据第一特征分离样品中的分子，以及第二基材，所述第二基材包括用于分离样品中的分子的第二分离的流体输送机构， 第二个特点。 第一和第二基板位于不同的平面中，并且第一和第二分离的流体输送机构通过受控而相互连接。 版权所有（C）2006，JPO＆NCIPI
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公开(公告)号：JP2006134877A
公开(公告)日：2006-05-25
申请号：JP2005311205
申请日：2005-10-26
Inventor： SEAWARD KAREN L , YIN HONGFENG , KILLEEN KEVIN P , SOBEK DANIEL , ROITMAN DANIEL
CPC classification number: H01J49/167 , G01N30/7266
Abstract: PROBLEM TO BE SOLVED: To provide an electrospray device capable of reproducing a Taylor cone by a device for a polymer without increasing the volume of the cone. SOLUTION: This electrospray device 108 comprises; a body 116; a tip 118 extending from the body 116 and containing a polymer material; and a hydrophobic coating 160 substantially selectively covering the tip 118. The hydrophobic coating 160 is formed of a nonconductive material. COPYRIGHT: (C)2006,JPO&NCIPI
Abstract translation: 解决的问题：提供能够通过聚合物的装置再生泰勒锥体而不增加锥体的电喷装置。 解决方案：该电喷雾装置108包括： 身体116; 从主体116延伸并包含聚合物材料的尖端118; 以及基本上选择性地覆盖尖端118的疏水涂层160.疏水涂层160由非导电材料形成。 版权所有（C）2006，JPO＆NCIPI
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公开(公告)号：WO2015047598A2
公开(公告)日：2015-04-02
申请号：PCT/US2014051708
申请日：2014-08-19
Applicant: AGILENT TECHNOLOGIES INC , YIN HONGFENG , BRENNEN REID A , LYSTER ERIC , SLOCUM ROGER
Inventor： YIN HONGFENG , BRENNEN REID A , LYSTER ERIC , SLOCUM ROGER
IPC: G01N30/26
CPC classification number: G01N30/606 , G01N30/6065 , G01N30/6086
Abstract: A liquid chromatography (LC) column includes a wall having a length along a central axis from the inlet end to the outlet end, the wall enclosing a column interior and having a column radius relative to the central axis, the wall comprising a structured portion configured such that the column radius varies along the length; and a plurality of particles packed in the column interior, wherein at least some of the particles are in contact with the structured portion.
Abstract translation: 液相色谱（LC）柱包括壁，该壁具有从入口端到出口端的中心轴线的长度，所述壁围绕柱内部并具有相对于中心轴线的柱半径，所述壁包括构造的结构部分 使得柱半径沿长度变化; 以及填充在塔内部的多个颗粒，其中至少一些颗粒与结构化部分接触。
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9.发明专利
公开(公告)号：DE102019212150A1
公开(公告)日：2021-02-18
申请号：DE102019212150
申请日：2019-08-13
Applicant: AGILENT TECHNOLOGIES INC
Inventor： GEOVANOS ARES , YIN HONGFENG , LANG MICHAEL , ORTMANN THOMAS
Abstract: System (1), umfassend: einen Chromatographiesäulenadapter (10) mit einem Kanal (11), der sich zwischen einer ersten Seite (13) und einer zweiten Seite (14) des Chromatographiesäulenadapters (10) erstreckt; eine Chromatographiesäule (30), die zur Fluidkommunikation mit dem Kanal (11) an der ersten Seite (13) des Chromatographiesäulenadapters (10) ankoppelbar ist; eine Kapillare (20), die zur Fluidkommunikation mit dem Kanal (11) an der zweiten Seite (14) des Chromatographiesäulenadapters (10) mit einer Stirnseite (22) voran in einer Einsetzrichtung (A) in den Kanal (11) einsetzbar ist. Um das Chromatographieverhalten zu verbessern, verjüngt sich eine Mantelfläche (21) der Kapillare (20) zur Stirnseite (22) hin und ist derart konfiguriert, dass in einem in den Kanal (11) eingesetzten Zustand bei Beaufschlagung der Kapillare (20) mit einer Kraft in Einsetzrichtung (A) eine Presspassung zwischen der Mantelfläche (21) der Kapillare (20) und dem Chromatographiesäulenadapter (10) im Bereich des Kanals (11) realisiert ist. Weiterhin ist ein System (60) zum Klemmen einer Chromatographiesäulenanordnung offenbart.
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公开(公告)号：GB2433449B
公开(公告)日：2011-01-26
申请号：GB0625308
申请日：2006-12-19
Applicant: AGILENT TECHNOLOGIES INC
Inventor： YIN HONGFENG , KILLENN KEVIN , BRENNEN REID
Abstract: Fluidic separation devices and methods with reduced sample broadening are provided. A column is located downstream from a holding chamber, and a flow providing means provides fluid flow effective to convey a sample along a flow path that extends from the holding chamber into the separation column. The sample is typically focused in the flow path upstream from the separation column. Optionally, the invention may be employed with electrospray mass spectrometry and in microfluidic applications.
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