公开(公告)号：EP1882737A4

公开(公告)日：2010-01-27

申请号：EP06756354

申请日：2006-05-18

Applicant: AJINOMOTO KK

Inventor： KURODA SHINJI ,  NOZAKI HIROYUKI ,  WATANABE KUNIHIKO ,  YOKOZEKI KENZO ,  IMABAYASHI YUKI

IPC: C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12P13/04

CPC classification number: C12N9/1014 ,  C12P13/06 ,  C12Y201/02001

公开(公告)号：EP2578203A4

公开(公告)日：2013-07-24

申请号：EP11786790

申请日：2011-05-27

Applicant: AJINOMOTO KK

Inventor： AMINO YUSUKE ,  TAKINO YOSHINOBU ,  KURODA SHINJI ,  IWASAKI KEIJI ,  KANEKO MEGUMI ,  OKURA FUMIE

IPC: A61K8/49 ,  A61Q1/02 ,  A61Q15/00 ,  A61Q17/00 ,  A61Q19/02 ,  C07D277/06 ,  C07D417/04 ,  C07D513/08

CPC classification number: C07D277/06 ,  A61K8/49 ,  A61K8/4926 ,  A61Q1/02 ,  A61Q15/00 ,  A61Q17/00 ,  A61Q19/02 ,  C07D417/04 ,  C07D513/08 ,  C07K5/06139

公开(公告)号：AT524544T

公开(公告)日：2011-09-15

申请号：AT06756354

申请日：2006-05-18

Applicant: AJINOMOTO KK

Inventor： KURODA SHINJI ,  NOZAKI HIROYUKI ,  WATANABE KUNIHIKO ,  YOKOZEKI KENZO ,  IMABAYASHI YUKI

IPC: C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12P13/04

公开(公告)号：CA2472133A1

公开(公告)日：2003-07-17

申请号：CA2472133

申请日：2002-12-27

Applicant: AJINOMOTO KK

Inventor： HIROSE NAOKO ,  OHNISHI TOMOYUKI ,  KURODA SHINJI ,  HAMADA TAKAYUKI

IPC: C07C303/40 ,  C07C303/44 ,  C07C311/18 ,  C07C311/41 ,  C07C303/36

Abstract: A process for producing high-purity crystals which comprises using a polar solvent as a good solvent (e.g., an alcohol or an alcohol/water mixed solven t) and water as a poor solvent to crystallize the benzenesulfonamide derivative represented by the following formula (1); novel crystals of the nitrobenzenesulfonamide derivative represented by the following formula (2), which is an intermediate for the derivative (1); and a process for producing the novel crystals.

公开(公告)号：EP2786741A4

公开(公告)日：2015-08-26

申请号：EP12853735

申请日：2012-11-30

Applicant: AJINOMOTO KK

Inventor： TAKINO YOSHINOBU ,  OKURA FUMIE ,  KURODA SHINJI

IPC: A61K8/49 ,  A61K8/34 ,  A61K8/36 ,  A61K8/44 ,  A61K8/60 ,  A61K8/64 ,  A61K8/97 ,  A61K31/426 ,  A61P17/00 ,  A61P17/16 ,  A61P43/00 ,  A61Q19/02

CPC classification number: A61K8/49 ,  A61K8/361 ,  A61K8/368 ,  A61K8/44 ,  A61K8/445 ,  A61K8/4973 ,  A61K8/498 ,  A61K8/602 ,  A61K8/64 ,  A61K8/97 ,  A61K31/426 ,  A61Q19/02

Abstract: Provided is a cosmetic agent superior in a whitening effect (including prophylaxis and removal of pigmented spot) and having high safety. In addition, a superior melanin production suppressive agent is provided. A cosmetic agent or melanin production suppressive agent comprising (A) a cysteine derivative represented by the formula (I) or a salt thereof: wherein X and Y are each independently OR 1 or NHR 2 wherein R 1 and R 2 are each independently a hydrogen atom or a C 1-22 alkyl group; Z is a hydrogen atom or a C 1-22 alkyl group; and W is a C 1-22 alkyl group, a C 1-22 alkoxy group or a C 1-22 alkylamino group, and (B) a whitening agent.

公开(公告)号：EP2239335A4

公开(公告)日：2011-07-06

申请号：EP09701789

申请日：2009-01-16

Applicant: AJINOMOTO KK

Inventor： KURODA SHINJI ,  SUGIYAMA MASAKAZU ,  WATANABE KUNIHIKO ,  SUZUKI SHUNICHI ,  YOKOZEKI KENZO ,  KASHIWAGI TATSUKI

IPC: C12P13/06 ,  C12N1/21 ,  C12N9/10 ,  C12N15/09

CPC classification number: C12N9/1029 ,  C12P13/04

公开(公告)号：AT442452T

公开(公告)日：2009-09-15

申请号：AT06010436

申请日：2006-05-19

Applicant: AJINOMOTO KK

Inventor： NOZAKI HIROYUKI ,  KURODA SHINJI ,  WATANABE KUNIHIKO ,  YOKOZEKI KENZO

IPC: C12P13/06 ,  C12N9/10

Abstract: The present invention provides a new method for producing ²-hydroxy amino acid and its optically-active isomer in a convenient manner. The ²-hydroxy amino acid is produced by reacting a predetermined D-±-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to a genus selected from the group consisting of genera Paracoccus, Aminobacter, and Ensifer.

公开(公告)号：DE602006009010D1

公开(公告)日：2009-10-22

申请号：DE602006009010

申请日：2006-05-19

Applicant: AJINOMOTO KK

Inventor： NOZAKI HIROYUKI ,  KURODA SHINJI ,  WATANABE KUNIHIKO ,  YOKOZEKI KENZO

IPC: C12P13/06 ,  C12N9/10

Abstract: The present invention provides a new method for producing ²-hydroxy amino acid and its optically-active isomer in a convenient manner. The ²-hydroxy amino acid is produced by reacting a predetermined D-±-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to a genus selected from the group consisting of genera Paracoccus, Aminobacter, and Ensifer.

公开(公告)号：AU2002362189A1

公开(公告)日：2003-07-24

申请号：AU2002362189

申请日：2002-12-27

Applicant: AJINOMOTO KK

Inventor： KURODA SHINJI ,  OHNISHI TOMOYUKI ,  HIROSE NAOKO

IPC: C07C303/40 ,  C07C303/44 ,  C07C311/18 ,  C07C311/41 ,  C07C303/36

Abstract: The present invention relates to a method of producing a highly pure crystal, which includes crystallization of a benzenesulfonamide derivative of the following formula (1) using a polar solvent as a good solvent (e.g., alcohol or a mixed solvent of alcohol and water) and water as a poor solvent, and a novel crystal of a nitrobenzenesulfonamide derivative of the following formula (2), which is an intermediate for the derivative, and a production method thereof:

公开(公告)号：JP2006320294A

公开(公告)日：2006-11-30

申请号：JP2005148659

申请日：2005-05-20

Applicant: AJINOMOTO KK

Inventor： NOZAKI HIROYUKI ,  KURODA SHINJI ,  WATABE OTOHIKO ,  YOKOZEKI KENZO

IPC: C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12P13/04

Abstract: PROBLEM TO BE SOLVED: To provide a new method for producing a β-hydroxyamino acid and an optically active substance thereof according to a simple technique. SOLUTION: A prescribed D-α-amino acid is reacted with 5,10-methylenetetrahydrofolic acid and/or a prescribed aldehyde in the presence of an enzyme derived from microorganisms belonging to any genus of the group consisting of the genera Paracoccus, Aminobacter and Ensifer. Thereby, the β-hydroxyamino acid is produced. COPYRIGHT: (C)2007,JPO&INPIT