公开(公告)号：WO2011021717A2

公开(公告)日：2011-02-24

申请号：PCT/JP2010064323

申请日：2010-08-18

Applicant: AJINOMOTO KK ,  SMIRNOV SERGEY VASILIEVICH ,  SAMSONOVA NATALIA NIKOLAEVNA ,  KOTLIAROVA VERONIKA ALEKSANDROVNA ,  RUSHKEVICH NATALIA YURIEVNA ,  FEDORINA EKATERINA ALEKSANDROVNA ,  SOKOLOV PAVEL MIKHAILOVICH ,  KOLOKOLOVA ALEKSANDRA VIKTOROVNA ,  OGAWA JUN ,  HIBI MAKOTO ,  SHIMIZU SAKAYU ,  IMABAYASHI YUKI ,  SUZUKI SHUNICHI ,  SUGIYAMA MASAKAZU

Inventor： SMIRNOV SERGEY VASILIEVICH ,  SAMSONOVA NATALIA NIKOLAEVNA ,  KOTLIAROVA VERONIKA ALEKSANDROVNA ,  RUSHKEVICH NATALIA YURIEVNA ,  FEDORINA EKATERINA ALEKSANDROVNA ,  SOKOLOV PAVEL MIKHAILOVICH ,  KOLOKOLOVA ALEKSANDRA VIKTOROVNA ,  OGAWA JUN ,  HIBI MAKOTO ,  SHIMIZU SAKAYU ,  IMABAYASHI YUKI ,  SUZUKI SHUNICHI ,  SUGIYAMA MASAKAZU

IPC: C12N9/02

CPC classification number: C12P13/06 ,  C12N9/0071 ,  C12P13/08 ,  C12P13/12

Abstract: A method for manufacturing hydroxylated amino acid, particularily hydroxylated isoleucine, hydroxylated methionine, hydroxylated threonine, hydroxylated leucine or hydroxylated valine, by enzymatic conversion using a dioxygenase.

Abstract translation: 通过使用双加氧酶的酶转化来制造羟基化氨基酸，特别是羟基化的异亮氨酸，羟基化甲硫氨酸，羟基化苏氨酸，羟基化亮氨酸或羟基化缬氨酸的方法。

公开(公告)号：EP1445323A4

公开(公告)日：2010-01-27

申请号：EP02783795

申请日：2002-12-09

Applicant: AJINOMOTO KK

Inventor： SUGIYAMA MASAKAZU ,  WATANABE KUNIHIKO ,  FUNAKOSHI NAO ,  AMINO YUSUKE ,  KAWAHARA SHIGERU ,  TAKEMOTO TADASHI

IPC: C12N9/88 ,  C12N15/55 ,  C12P13/04 ,  C12P13/14 ,  C12P17/10

CPC classification number: C12P17/10 ,  C12N9/88

Abstract: A process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin hopeful as a sweetener or the like, which comprises converting a substituted alpha -keto acid of the general formula (1) into a glutamic acid derivative of the general formula (2) in the presence of an enzyme catalyzing the conversion.

公开(公告)号：EP1026254A4

公开(公告)日：2003-05-28

申请号：EP98947895

申请日：1998-10-15

Applicant: AJINOMOTO KK

Inventor： SUGIYAMA MASAKAZU ,  SUZUKI SHUNICHI ,  MIHARA YASUHIRO ,  HASHIGUCHI KENICHI ,  YOKOZEKI KENZO

IPC: C12P7/18 ,  C12R1/01 ,  C12R1/02 ,  C12R1/025 ,  C12R1/03 ,  C12R1/04 ,  C12R1/06 ,  C12R1/065 ,  C12R1/13 ,  C12R1/15 ,  C12R1/18 ,  C12R1/20 ,  C12R1/265 ,  C12R1/365 ,  C12R1/38 ,  C12R1/465 ,  C12R1/48 ,  C12R1/545 ,  C12R1/56 ,  C12R1/58

CPC classification number: C12P7/18

Abstract: A process for preparing xylitol, characterized by allowing a microorganism belonging to the genus Gluconobacter, Acetobacter, Achromobacter, Agrobacterium, Arthrobacter, Azotobacter, Brevibacterium, Corynebacterium, Erwinia, Flavobacterium, Micrococcus, Norcardia, Planococcus, Pseudomonas, Rhodococcus, Morganella, Actinomadura, Actinomyces, or Streptomyces and having the capability of converting D-arabitol to xylitol to act on D-arabitol and harvesting the xylitol thus produced.

Abstract translation: 一种制备木糖醇的方法，其特征在于使属于葡糖杆菌属，醋杆菌属，无色杆菌属，农杆菌属，节杆菌属，固氮菌属，短杆菌属，棒杆菌属，欧文氏菌属，黄杆菌属，微球菌属，诺卡氏菌属，Planococcus球菌属，假单胞菌属，红球菌属，摩根氏菌属，Actinomadura属，放线菌属 或链霉菌属，并具有将D-阿拉伯糖醇转化成木糖醇以作用于D-阿拉伯醇并收获如此产生的木糖醇的能力。

公开(公告)号：EP1580268A4

公开(公告)日：2006-07-19

申请号：EP03777385

申请日：2003-12-09

Applicant: AJINOMOTO KK

Inventor： SUGIYAMA MASAKAZU ,  WATANABE KUNIHIKO ,  KASHIWAGI TATSUKI ,  SUZUKI EI-ICHIRO

IPC: C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N9/10 ,  C12P17/10 ,  C12N15/09 ,  C12N5/10 ,  C12P13/04

CPC classification number: C12N9/1096 ,  C12P17/10

Abstract: By substituting an amino acid residue at least at one position participating in the efficient formation of (2R,4R)-monatin (100-position, 180- to 183-positions, 243-position and 244-position) in the amino acid sequence of wild type D-aminotransferase represented by SEQ ID NO:2 in Sequence Listing, the D-aminotransferase can be mutated so that it can efficiently produce (2R,4R)-monatin having an elevated sweetness from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid.

公开(公告)号：DK2240574T3

公开(公告)日：2016-02-08

申请号：DK08863991

申请日：2008-12-22

Applicant: AJINOMOTO KK

Inventor： SMIRNOV SERGEY VASILIEVICH ,  SAMSONOVA NATALIA NIKOLAEVNA ,  KOTLIAROVA VERONIKA ALEKSANDROVNA ,  RUSHKEVICH NATALIA YURIEVNA ,  BEZNOSCHENKO OLGA SERGEEVNA ,  BACHINA TATYANA ALEKSANDROVNA ,  IMABAYASHI YUKI ,  SUGIYAMA MASAKAZU ,  SUZUKI SHUNICHI

IPC: C12N9/02 ,  C12P13/04 ,  C12P13/06 ,  C12P13/24

公开(公告)号：CA2714881C

公开(公告)日：2012-10-23

申请号：CA2714881

申请日：2003-08-26

Applicant: AJINOMOTO KK

Inventor： SUGIYAMA MASAKAZU ,  WATANABE KUNIHIKO

IPC: C12N15/09 ,  C12N15/60 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N9/10 ,  C12N9/88 ,  C12P7/40 ,  C12P7/42 ,  C12P7/50 ,  C12P13/04 ,  C12P13/14 ,  C12P17/10 ,  C12P21/06

Abstract: 4-(Indol-3-ylmethyl),4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.

公开(公告)号：AT463568T

公开(公告)日：2010-04-15

申请号：AT03792838

申请日：2003-08-26

Applicant: AJINOMOTO KK

Inventor： SUGIYAMA MASAKAZU ,  WATANABE KUNIHIKO

IPC: C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N9/88 ,  C12N15/60 ,  C12P7/40 ,  C12P7/42 ,  C12P7/50 ,  C12P13/04 ,  C12P13/14 ,  C12P17/10 ,  C12P21/06

Abstract: 4-(Indol-3-ylmethy)-4-hydroxy-2-oxogiutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas , Erwinia , Flavobacterium , or Xanthomonas.

公开(公告)号：AU2003289264A1

公开(公告)日：2004-06-30

申请号：AU2003289264

申请日：2003-12-09

Applicant: AJINOMOTO KK

Inventor： SUGIYAMA MASAKAZU ,  WATANABE KUNIHIKO ,  KASHIWAGI TATSUKI ,  SUZUKI EI-ICHIRO

IPC: C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N9/10 ,  C12P17/10 ,  C12N15/09 ,  C12P13/04 ,  C12N5/10

Abstract: A D-aminotransferase can be modified so as to efficiently produce (2R, 4R) -monatin having high sweetness intensity from 4- (indol-3-ylmethyl) -4-hydroxy-2-oxoglutaric acid by substituting an amino acid at least at one of positions (positions 100, 180 to 183, 243 and 244) involved in efficiently producing the (2R, 4R) -monatin in an amino acid sequence of a wild-type D-aminotransferase represented in SEQ ID NO:2.

公开(公告)号：CA2469012A1

公开(公告)日：2003-07-10

申请号：CA2469012

申请日：2002-12-09

Applicant: AJINOMOTO KK

Inventor： FUNAKOSHI NAO ,  KAWAHARA SHIGERU ,  TAKEMOTO TADASHI ,  AMINO YUSUKE ,  SUGIYAMA MASAKAZU ,  WATANABE KUNIHIKO

IPC: C12N9/88 ,  C12N15/55 ,  C12P13/04 ,  C12P13/14 ,  C12P17/10

Abstract: A process for producing efficiently glutamic acid derivatives (including sal ts thereof) such as monatin hopeful as a sweetener or the like, which comprises converting a substituted .alpha.-keto acid of the general formula (1) into a glutamic acid derivative of the general formula (2) in the presence of an enzyme catalyzing the conversion.

公开(公告)号：EP2239335A4

公开(公告)日：2011-07-06

申请号：EP09701789

申请日：2009-01-16

Applicant: AJINOMOTO KK

Inventor： KURODA SHINJI ,  SUGIYAMA MASAKAZU ,  WATANABE KUNIHIKO ,  SUZUKI SHUNICHI ,  YOKOZEKI KENZO ,  KASHIWAGI TATSUKI

IPC: C12P13/06 ,  C12N1/21 ,  C12N9/10 ,  C12N15/09

CPC classification number: C12N9/1029 ,  C12P13/04