公开(公告)号：WO02085840A9

公开(公告)日：2003-03-06

申请号：PCT/JP0203754

申请日：2002-04-16

Applicant: AJINOMOTO KK ,  KAWAHARA SHIGERU ,  TAKEMOTO TADASHI ,  FUJITA SHINJI ,  OHNO AYAKO

Inventor： KAWAHARA SHIGERU ,  TAKEMOTO TADASHI ,  FUJITA SHINJI ,  OHNO AYAKO

IPC: C07C231/02 ,  C07C231/08 ,  C07C233/47 ,  C07K5/072 ,  C07K5/075 ,  C12P13/02 ,  C12P13/20 ,  C12P21/02 ,  C07K1/06 ,  C07K1/30

CPC classification number: C07K5/0613 ,  C07C231/02 ,  C07C231/08 ,  C12P13/02 ,  C12P13/20 ,  C12P21/02 ,  C07C233/47

Abstract: A process for efficiently and industrially advantageously producing an N-formylamino acid by reacting an amino acid or its salt with formamide and/or methyl formate in the presence of a base. A process for efficiently and industrially advantageously producing N-formyl- alpha -aspartylphenylalanine methyl ester, which is a precursor of aspartame, by an enzymatic fusion reaction of N-formylaspartic acid with phenylalanine methyl ester wherein the concentration of N-formylaspartic acid is specified or the reaction is carried out in the presence of a trialkyl phosphate. A process for efficiently and industrially advantageously producing N-formyl- alpha -aspartylphenylalanine methyl ester having a high purity by adjusting the pH value of a phenylalanine methyl ester adduct of N-formyl- alpha -aspartylphenylalanine methyl ester.

Abstract translation: 一种通过在碱存在下使氨基酸或其盐与甲酰胺和/或甲酸甲酯反应而有效和工业上有利地生产N-甲酰氨基酸的方法。 通过N-甲酰天冬氨酸与苯丙氨酸甲酯的酶融合反应有效地产生N-甲酰基-α-天冬氨酰苯丙氨酸甲酯（其是天冬甜素的前体）的方法，其中指定N-甲酰天冬氨酸的浓度或 反应在磷酸三烷基酯存在下进行。 通过调节N-甲酰基-α-天冬酰苯基苯丙氨酸甲酯的苯丙氨酸甲酯加合物的pH值，有效地和工业上有利地生产具有高纯度的N-甲酰基-asp-酰基苯丙氨酸甲酯的方法。

公开(公告)号：WO0147949A9

公开(公告)日：2001-09-20

申请号：PCT/JP0009247

申请日：2000-12-25

Applicant: AJINOMOTO KK ,  NAGASHIMA KAZUTAKA ,  AOKI YUUICHI ,  ONO ERIKO ,  TAKEMOTO TADASHI

Inventor： NAGASHIMA KAZUTAKA ,  AOKI YUUICHI ,  ONO ERIKO ,  TAKEMOTO TADASHI

IPC: A23L27/30 ,  C07K5/072 ,  C07K5/075 ,  A23L1/236

CPC classification number: C07K5/06113 ,  A23L27/32

Abstract: Commercially favorable crystals of N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L- alpha -aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener with a high degree of sweetness, having a high stability and a good purity.

Abstract translation: 商业上有利的N- [N- [3-（3-羟基-4-甲氧基苯基）丙基] -L-α-天冬氨酰基] -L-苯丙氨酸1-甲酯晶体，其可用作高度甜味剂的甜味剂 甜度高，稳定性高，纯度好。

公开(公告)号：EP1719758A4

公开(公告)日：2009-07-15

申请号：EP05704032

申请日：2005-01-18

Applicant: AJINOMOTO KK

Inventor： MORI KENICHI ,  TAKEMOTO TADASHI

IPC: C07D209/20 ,  A23L27/30 ,  C07B55/00 ,  C07B57/00

CPC classification number: C07D209/20 ,  A23L27/31

Abstract: A process for efficiently producing a monatin useful as a sweetener, especially an optically active monatin, comprising carrying out a reaction of isomerization at 2-position of a monatin whose 2-position and 4-position configurations are different from each other in the presence of an aldehyde in a mixed solvent of water and organic solvent at a pH of 4 to 11 and simultaneously performing crystallization of a monatin whose 2-position and 4-position configurations are identical with each other or a salt thereof.

公开(公告)号：EP1449832A4

公开(公告)日：2005-02-02

申请号：EP02783681

申请日：2002-11-29

Applicant: AJINOMOTO KK

Inventor： AMINO YUSUKE ,  YUZAWA KAZUKO ,  MORI KENICHI ,  TAKEMOTO TADASHI

IPC: A23L2/60 ,  A23L27/20 ,  A23L27/30 ,  C07C229/36 ,  C07D209/08 ,  C07D209/20 ,  A23G3/00 ,  A23L1/226 ,  A23L1/236 ,  C07D403/06 ,  C07D405/06

CPC classification number: C07D209/20 ,  A23L2/60 ,  A23L27/30 ,  A23L27/32

Abstract: It is intended to newly provide crystals of non-natural stereoisomer salts of monatin which are usable as sweeteners. Because of being stable and having a high degree of sweetness, these crystals are expected as useful as sweeteners or components thereof as well as agents for imparting sweetness to foods and drinks. It is also possible to provide, for example, sweeteners and sweetened foods and drinks with the use of the above salt crystals as novel sweetening substances. These stereoisomer salts include (2S,4R), (2R,4R) and (2R,4S) isomer salts of monatin. Among all, the (2R,4R) isomer salts of monatin are particularly favorable.

公开(公告)号：EP0937706A4

公开(公告)日：2003-07-09

申请号：EP96939297

申请日：1996-11-21

Applicant: AJINOMOTO KK

Inventor： HIJIYA TOYOTO ,  IKEDA TORU ,  MORI KENICHI ,  YUKAWA TOSHIHIDE ,  TAKEMOTO TADASHI ,  KAMADA HAJIME

IPC: A23K1/00 ,  A23K1/16 ,  A23K1/175 ,  A23K1/18 ,  C07C229/26 ,  C07C279/14 ,  C07C229/14

CPC classification number: C07C229/26 ,  A23K20/142 ,  A23K20/147 ,  A23K20/26 ,  A23K40/10 ,  A23K40/35 ,  A23K50/10 ,  C07C279/14 ,  Y10S426/807

Abstract: Phosphoric acid- aminoacid-polyvalent metal complex salts of formula RaMgbMcHdPO4.nH2O (I) and RaaMgbaMcaHdPO4(PO3)m.n1H2O (II) are new. R = cation of a basic amino acid; M = m-valent metal, but not Mg; m = 2 or 3; a = 0.05-1.0; b = 0.85-1.43; c = 0.02-0.6; d = 0-0.3; a+2b+mc+d = 3; n = 0-20; aa = 0.05-0.4; ba = 0.9-1.47; ca = 0.01-1.4; d = 0-0.3; aa+2ba+mXca+d = m+3; m = 0-1.12. Also claimed is a powder or granular feed additive composition for ruminants containing a complex (I) which is insoluble in neutral and alkaline water, and soluble in acidic water.

公开(公告)号：EP1042964A4

公开(公告)日：2001-05-23

申请号：EP98954772

申请日：1998-11-20

Applicant: AJINOMOTO KK

Inventor： ISHIDA HIROTOSHI ,  NAGAI TAKESHI ,  TAKEMOTO TADASHI ,  SUZUKI YUICHI

IPC: A23L27/30 ,  C07K5/075 ,  A23L1/236 ,  C07D291/06 ,  C07K1/12 ,  C07K5/06

CPC classification number: A23L27/32

Abstract: A sweetener composition improved in the solubility of an otherwise poorly soluble high-sweetness synthetic sweetener aspartame (APM), characterized by comprising aspartame and acesulfame K as the active ingredient selected in such a manner that acesulfame K accounts for 5-90 wt.% of the whole and that the grain diameter of each ingredient falls within the region where the velocity of dissolution of the mixture thereof is greater than that of aspartame alone.

Abstract translation: 甜味剂组合物改善了其他溶解性差的高甜度合成甜味剂阿斯巴甜（APM）的溶解性，其特征在于包含阿斯巴甜和乙酰磺胺酸钾作为活性成分，其选择方式使得乙酰磺胺酸K占所述组合物的5-90重量％ 整体，并且每种成分的粒径落入其混合物的溶解速度大于单独阿斯巴甜的速度的区域内。

公开(公告)号：EP1042963A4

公开(公告)日：2001-05-23

申请号：EP98954771

申请日：1998-11-20

Applicant: AJINOMOTO KK

Inventor： ISHIDA HIROTOSHI ,  NAGAI TAKESHI ,  TAKEMOTO TADASHI ,  SUZUKI YUICHI

IPC: A23L27/00 ,  A23L27/30 ,  C07K5/075 ,  A23L1/236 ,  C07D291/06 ,  C07K1/12 ,  C07K5/06

CPC classification number: A23L27/32

Abstract: A granular sweetener improved in the solubility of an otherwise poorly soluble high-sweetness synthetic sweetener aspartame (APM), characterized by containing aspartame and acesulfame K as the active ingredient in such a manner that acesulfame K accounts for 5-90 wt.% of the whole and comprising granules with the maximum grain diameter of about 1,400 mu m or less.

公开(公告)号：EP1806408A4

公开(公告)日：2011-04-13

申请号：EP05787567

申请日：2005-09-29

Applicant: AJINOMOTO KK

Inventor： SUGIYAMA MASAKAZU ,  WATANABE KUNIHIKO ,  TAKEMOTO TADASHI ,  MORI KENICHI

IPC: C12P13/04 ,  C12P13/22 ,  C12R1/01 ,  C12R1/185 ,  C12R1/19

CPC classification number: C12P13/227 ,  C12P13/04 ,  C12R1/01 ,  C12R1/185 ,  C12R1/19

公开(公告)号：EP1236713A4

公开(公告)日：2004-10-13

申请号：EP00974890

申请日：2000-11-09

Applicant: AJINOMOTO KK

Inventor： KAWAHARA SHIGERU ,  MORI KENICHI ,  NAGASHIMA KAZUTAKA ,  TAKEMOTO TADASHI

IPC: C07C45/41 ,  C07C47/277 ,  C07C51/367 ,  C07C303/30 ,  C07C309/66 ,  C07K5/072 ,  C07K5/075 ,  C07K5/06

CPC classification number: C07C51/367 ,  C07C45/41 ,  C07C47/277 ,  C07C303/30 ,  C07K5/06113 ,  C07C59/64 ,  C07C309/66

Abstract: 3-(3-Hydroxy-4-methoxyphenyl)-3-methylbutyric acid can be obtained by substituting the substituent at the 3-position of the benzene ring of a butyric acid derivative which can be easily and efficiently produced by reacting a hydroxyl-protected 2-methoxyphenol, wherein the hydroxyl group of 2-methoxyphenol is protected in the form of a sulfonate, with 3-methylcrotonic acid in the presence of an acid. By further converting the carboxyl group into a formyl group, 3-(3-hydroxy-4-methoxyphenyl)-3-methyl butyl aldehyde can be easily produced. This aldehyde derivative can be easily derived into a compound, which is excellent as a sweetener with a high sweetness, by reductive alkylation with Aspartame.

公开(公告)号：EP1020431A4

公开(公告)日：2001-04-11

申请号：EP98967108

申请日：1998-08-19

Applicant: AJINOMOTO KK

Inventor： TAKEMOTO TADASHI

IPC: A23L27/30 ,  C07C231/24 ,  C07C237/12 ,  C07C237/20 ,  C07K5/072 ,  C07K5/075 ,  C07K5/06

CPC classification number: C07K5/06113 ,  C07C231/24 ,  C07C237/20

Abstract: A method of purifying and recovering a sweetener efficiently in a high yield without conducting complicated steps, which comprises contacting crude methyl N-(3,3-dimethylbutyl)-α-L-aspartyl-L-phenylalaninate containing at least methyl α-L-aspartyl-L-phenylalaninate as an impurity with a mixed solvent having two layers respectively consisting of water and an organic solvent immiscible with water to extract the methyl N-(3,3-dimethylbutyl)-α-L-aspartyl-L-phenylalaninate with the organic solvent layer.