Abstract:
PROBLEM TO BE SOLVED: To provide a new enzyme derived from a microorganism and recognizing D-aspartic acid in a peptide chain and specifically cleaving the C-terminus side thereof and to provide the new microorganism producing the enzyme. SOLUTION: The microorganism produces the paenidase (D-aspartic acid-specific endopeptidase). The microorganism is preferably Paenibacillus sp. B38 strain. COPYRIGHT: (C)2007,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide abone growth accelerators and bone growth accelerating food edible as food, free from adverse effect, and useful for preventing osteoporosis, by using foods grown in nature. SOLUTION: The purpose is accomplished by the bone growth accelerators isolated from mushrooms and purified having a chemical structure depicted by (22E,24R)-ergosta-7,22-diene-3β,5α,6β-triol and the bone growth accelerating foods using the mushrooms containing the ingredients depicted by the above chemical structure.
Abstract:
PROBLEM TO BE SOLVED: To provide an edible oil and fat composition containing 1,2-diacylglycero-3-acetate of Akebia quinata oil as a main ingredient, being difficult to become a substrate for hydrolysis reaction by a lipase which is a lipid digestive enzyme, suppressing increase of blood triacylglycelol (neutral fat) after intake, having less accumulation to bodies and having good storage stability and flavor. SOLUTION: The method for producing a liquid general-purpose type oil containing 1,2-diacylglycero-3-acetate as a main ingredient comprises drying seeds of a plant of the family Lardizabalaceae, squeezing oil from the seeds or extracting the seeds with a solvent to prepare a crude raw oil, adding 3-20% water to the crude raw oil, stirring these components for 5-30 min at 50-120°C, leaving the mixture to stand overnight to remove bilirubin content and gum mainly containing phospholipid, filtering supernatant oils and fats and producing the liquid general-purpose oil and fat composition. COPYRIGHT: (C)2008,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide an aldose reductase inhibitor and an agent for removing active oxygen which are used for conventional foods or food materials and also ensure safety and almost free from side effects and further has extracts from agricultural and marine products as an effective component. SOLUTION: The aldose reductase inhibitor and the agent for removing active oxygen contain, as an effective component, at least one compound selected from the group consisting of methyl chlorogenate, quercetin-3-O- xylopyranosyl glucopyranoside, kaempferol-3-O-xylopyranosyl glucopyranoside, quercetin-3-O-glucopyranoside and quercetin-3-O-(6"-acetylglucopyranoside).
Abstract:
PROBLEM TO BE SOLVED: To provide a renin inhibitor that can be continued for a long period of time by purifying a resin inhibitor that brings about a hypotensive effect by inhibiting renin being one vasopressor principle and is derived from a food having a slight possibility of side effect and by determining a structure. SOLUTION: The renin inhibitor includes soyasaponin I obtained by heat-treating soybean hypocotyl and treating an extracted solution derived from hypocotyl by chromatography or its pharmaceutically acceptable salt. The hypotensive agent includes soyasaponin I as an active ingredient. COPYRIGHT: (C)2010,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide an antibacterial active substance which can safely be used. SOLUTION: A water-soluble fraction and residues are obtained by subjecting the fruit bodies of Catathelasma ventricosum to a water extraction treatment, and their further purified products are obtained.
Abstract:
PROBLEM TO BE SOLVED: To provide a method for producing fermented foods such as Miso by selecting koji mold Aspergillus Oryzae suitable for producing high contents of free fatty acids and fatty acid ethyl esters which are known as biologically active substances exhibiting antimutagenicity, etc., in production of fermented foods such as Miso and then using the koji mold. SOLUTION: The present invention provides Aspergillus Oryzae AOK138 strain (FERM AP-20550) having ≥15.0 μ/g enzyme activity of lipase and ≥0.75 μ/g enzyme activity of cellulase in rice koji produced by an ordinary method and provides a method for producing the fermented foods by using koji mold as a seed koji. COPYRIGHT: (C)2007,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a metastasis-controlling substance excellent in controlling metastasis of tumor cells such as malignant melanoma, neuroblastoma, glioblastoma and astrocytoma, and a composition containing the same. SOLUTION: A triterpene derivative for controlling metastasis, represented by formula (I) or (II) (wherein R is a hydroxy group or -O-CO-R'; and R' is a 1-23C alkyl group or a 6-23C group containing an aromatic ring), or a pharmacologically acceptable salt thereof is provided. COPYRIGHT: (C)2006,JPO&NCIPI
Abstract:
PROBLEM TO BE SOLVED: To obtain a Tonburi tea consisting of broom cypress seeds, without giving a strange feeling to throat on drinking and not having a specific grassy- smell by using the broom cypress seeds as a raw material. SOLUTION: This Tonburi tea consists of broom cypress seeds of which bitter components such as a saponin is heat-decomposed by a roast treatment to make 0.5-3.0% water content thereof, or is obtained by blending at least one or more kinds of a dried shiitake mushroom (Lentinus edodes), a roast- treated unpolished rice, a roasted tea, a coarse tea with 30-90 wt.% broom cypress seeds roasted to have 0.5-3.0 wt.% water content for masking the grassy- smell of the broom cypress seeds.
Abstract:
PROBLEM TO BE SOLVED: To provide an anticancer material having excellent anticancer activity, and to provide a composition containing the material. SOLUTION: The anticancer triterpene derivative represented by formula (I) [wherein, R is α-H, β-O-R' (R' is a hydrogen atom or an optional acyl group) or =O], and an analogue thereof or a pharmaceutically acceptable salt thereof are provided. COPYRIGHT: (C)2009,JPO&INPIT