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    Method for producing nerve growth factor-like agent
    1.
    发明专利
    Method for producing nerve growth factor-like agent 审中-公开
    生产神经生长因子代谢剂的方法

    公开(公告)号：JP2012157325A

    公开(公告)日：2012-08-23

    申请号：JP2011020784

    申请日：2011-02-02

    Applicant: Akita Konno Shoten:Kk ,  Akita Prefecture ,  株式会社 秋田今野商店 ,  秋田県

    Inventor： TOMATSU MAKOTO ,  KONNO HIROSHI ,  SATO TSUTOMU

    IPC: C12N1/16 ,  A23L11/20 ,  A61K36/06 ,  A61P25/00

    Abstract: PROBLEM TO BE SOLVED: To provide a microorganism usable in food production, and a nerve growth factor-like agent derived from natural products using the microorganism.SOLUTION: A microorganism usable in food production for producing nerve growth factor-like active components, Saccharomyces kluyveri strain, and a method for producing a nerve growth factor-like agent using the strain are provided. After the strain is cultured in an YM culture medium for yeasts, harvesting, adding ethanol, heating, extracting, and removing residues through centrifugation are carried out, whereby a yeast extract containing the nerve growth factor-like active components can be obtained.

    Abstract translation: 待解决的问题：提供可用于食品生产的微生物和使用该微生物衍生自天然产物的神经生长因子样试剂。 解决方案：提供可用于食品生产中用于产生神经生长因子样活性成分的酵母，克鲁维酵母菌株和使用该菌株产生神经生长因子样试剂的方法。 将菌株在用于酵母的YM培养基中培养后，进行收获，加入乙醇，加热，提取和通过离心除去残留物，从而可以获得含有神经生长因子的活性成分的酵母提取物。 版权所有（C）2012，JPO＆INPIT

    beta-MANNANASE, ITS PRODUCING MICROORGANISM AND METHOD FOR PRODUCING THE SAME
    2.
    发明专利
    beta-MANNANASE, ITS PRODUCING MICROORGANISM AND METHOD FOR PRODUCING THE SAME 失效

    公开(公告)号：JP2002065257A

    公开(公告)日：2002-03-05

    申请号：JP2000260348

    申请日：2000-08-30

    Applicant: AKITA PREFECTURE

    Inventor： TOEDA KAZUYOSHI ,  TOMATSU MAKOTO ,  KAWABATA YASUYUKI

    IPC: C12N9/42 ,  C12N1/20 ,  C12R1/12

    Abstract: PROBLEM TO BE SOLVED: To search a microorganism capable of efficiently producing a novel β-mannanase from an inexpensive raw material and establish a method for producing the enzyme by using the microorganism. SOLUTION: This β-mannanase acts on mannan, glucomannan, galactomannan and their oligosaccharides, produces mannoes, mannooligosaccharides, glucomannooligosaccharides and galactomannooligosaccharides by hydrolyzing their β-1,4-D-mannopyranosyl bonds, has 8.65 isoelectric point (by electrofocussing electrophoresis), 34 kDa molecular weight (by SDS-polyacrylamide gel electrophoresis) and an N-terminal amino acid sequence expressed by sequence No.1 in the sequence table. Bacillus polymyxa KT551 strain having a potency to produce the β-mannanase and a method for producing the aforesaid β-mannanase are provided.

    NEW ANTINEOPLASTIC PROTEIN AND ITS PRODUCTION
    3.
    发明专利
    NEW ANTINEOPLASTIC PROTEIN AND ITS PRODUCTION 失效

    公开(公告)号：JPH11228598A

    公开(公告)日：1999-08-24

    申请号：JP3972798

    申请日：1998-02-05

    Applicant: AKITA PREFECTURE

    Inventor： TOMATSU MAKOTO ,  ISHIKAWA MASAKO ,  SHIBAMOTO NORIO

    IPC: C12N5/04 ,  A61K36/25 ,  A61K38/00 ,  A61P35/00 ,  C07K1/36 ,  C07K14/415 ,  A61K35/78

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject new protein comprising an antineoplastic protein having a specific molecular weight and derived from Aralia elata, abundant also in resource, exhibiting selective lethal action on tumor cells and useful for medicines, food additives, etc., as an antineoplastic agent, an apoptosis- inducing agent, etc. SOLUTION: This new antineoplastic protein is derived from Aralia elata and has about 36 kDa and about 33 kDa molecular weight of subunit by SDS electrophoresis and about 140 kDa molecular weight by concentration gradient gel electrophoresis and the protein is abundant also in resource and exhibits selective lethal action on tumor cells and is useful for medicines, food additives, food raw materials, etc., as an antineoplastic agent, an apoptosis-inducing agent, etc. The protein is obtained by bringing an extract obtained from Aralia elata by extraction with an aqueous solvent into contact with an anion exchange resin to carry out absorption treatment, successively eluting the adsorbate with an eluting agent from a column and purifying the eluate by gel electrophoresis, lectin column treatment, hydrophobic column treatment and gel filtration column treatment.

    ALDOSE REDUCTASE INHIBITOR
    4.
    发明专利
    ALDOSE REDUCTASE INHIBITOR 审中-公开

    公开(公告)号：JP2003226640A

    公开(公告)日：2003-08-12

    申请号：JP2002025013

    申请日：2002-02-01

    Applicant: AKITA PREFECTURE

    Inventor： SHINDO AKIRA ,  TOMATSU MAKOTO

    IPC: A23L1/30 ,  A61K31/122 ,  A61K36/60 ,  A61P3/10 ,  A61P43/00 ,  A61K35/78

    Abstract: PROBLEM TO BE SOLVED: To provide an aldose reductase inhibitor comprising a component derived from a farm/marine product as an active ingredient conventionally used as food or a food material, without any safety problem and substantially free of concern about side effects for various diseases including diabetes. SOLUTION: This aldose reductase inhibitor comprises a hop-derived alpha- acid and/or isoalpha-acid. The foods or food materials containing the inhibitor are also provided. COPYRIGHT: (C)2003,JPO

    New antitumor protein
    6.
    发明专利
    New antitumor protein 审中-公开

    公开(公告)号：JP2004075676A

    公开(公告)日：2004-03-11

    申请号：JP2003172939

    申请日：2003-06-18

    Applicant: Akita Prefecture ,  Akiyoshi Ikuta ,  生田 安喜良 ,  秋田県

    Inventor： TOMATSU MAKOTO ,  IKUTA AKIYOSHI

    IPC: A61K38/00 ,  A61K36/00 ,  A61K36/25 ,  A61P35/00 ,  C07K1/18 ,  C07K1/22 ,  C07K1/26 ,  C07K1/34 ,  C07K7/08 ,  A61K35/78

    Abstract: PROBLEM TO BE SOLVED: To provide a protein stably obtainable and having higher activity of selecting tumor cells than ever. SOLUTION: The antitumor protein derived from calluses of an Araliaceae plant, a method for producing the protein, and an antitumor agent containing the protein as an active ingredient are provided, respectively. The antitumor protein has higher selectivity on the tumor cells when compared with another protein derived from a plant body of the plant. Because the protein is derived from the calluses, the protein is stably obtainable all the year around, although the plant body is unstable as a source of supplying the protein due to its seasonability. Further, productivity of the protein is expected to be improved by studying conditions of culturing the calluses. COPYRIGHT: (C)2004,JPO

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