公开(公告)号：WO1998025620A1

公开(公告)日：1998-06-18

申请号：PCT/US1997015727

申请日：1997-09-05

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  ALI, Yusuf ,  BECK, Robert, E. ,  SPORT, Rex, C.

IPC: A61K31/54

CPC classification number: A61K31/542 ,  A61K9/0048 ,  A61K31/77 ,  Y10S514/912 ,  A61K2300/00

Abstract: Ophthalmic suspensions containing brinzolamide or brinzolamide and a beta-blocker and processes for manufacturing the suspensions are disclosed. The use of Tyloxapol or Triton X-100 avoids chrystallization of brinzolamide after autoclaving.

Abstract translation: 公开了含有brinzolamide或brinzolamide和β-阻滞剂的眼用悬浮液和制备悬浮液的方法。 Tyloxapol或Triton X-100的使用避免了高压灭菌后呋喃唑胺的结晶。

公开(公告)号：EP0941094B1

公开(公告)日：2001-12-05

申请号：EP97939835.1

申请日：1997-09-05

Applicant: ALCON LABORATORIES, INC.

Inventor： ALI, Yusuf ,  BECK, Robert, E. ,  SPORT, Rex, C.

IPC: A61K31/54

CPC classification number: A61K31/542 ,  A61K9/0048 ,  A61K31/77 ,  Y10S514/912 ,  A61K2300/00

Abstract: Ophthalmic suspensions containing brinzolamide or brinzolamide and a beta-blocker and processes for manufacturing the suspensions are disclosed. The use of Tyloxapol or Triton X-100 avoids chrystallization of brinzolamide after autoclaving.

公开(公告)号：EP0941094A1

公开(公告)日：1999-09-15

申请号：EP97939835.0

申请日：1997-09-05

Applicant: ALCON LABORATORIES, INC.

Inventor： ALI, Yusuf ,  BECK, Robert, E. ,  SPORT, Rex, C.

IPC: A61K31 ,  A61K9 ,  A61P27

CPC classification number: A61K31/542 ,  A61K9/0048 ,  A61K31/77 ,  Y10S514/912 ,  A61K2300/00

Abstract: Ophthalmic suspensions containing brinzolamide or brinzolamide and a beta-blocker and processes for manufacturing the suspensions are disclosed. The use of Tyloxapol or Triton X-100 avoids chrystallization of brinzolamide after autoclaving.