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公开(公告)号：WO2017192485A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030501
申请日：2017-05-02
Applicant: AMGEN INC.
Inventor： CHEN, Xiaoqi , CHEN, Yinhong , CHENG, Alan C. , CONNORS, Richard V. , DEBENEDETTO, Mikkel V. , DRANSFIELD, Paul John , FU, Zice , HARVEY, James S. , HEATH, Julie Anne , HEDLEY, Simon J. , HOUZE, Jonathan , JUDD, Ted C. , KHAKOO, Aarif Yusuf , KOPECKY, David J. , LAI, Su-Jen , MA, Zhihua , NISHIMURA, Nobuko , OLSON, Steven H. , PATTAROPONG, Vatee , SWAMINATH, Gayathri , WANG, Xiaodong , YEH, Wen-Chen
IPC: C07D401/14 , C07D403/04 , C07D405/14 , C07D403/14 , C07D405/04 , C07D409/14 , C07D471/04 , A61K31/4196 , A61P9/00
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
Abstract translation: 式I和式II的化合物，其药学上可接受的盐，任何前述的立体异构体或其混合物是APJ受体的激动剂，并且可用于治疗心血管和其他病症。 式I和式II的化合物具有以下结构：其中变量的定义在本文中提供。
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公开(公告)号：WO2016187308A1
公开(公告)日：2016-11-24
申请号：PCT/US2016/033088
申请日：2016-05-18
Applicant: AMGEN INC.
Inventor： CHEN, Ning , CHEN, Xiaoqi , CHEN, Yinhong , CHENG, Alan C. , CONNORS, Richard V. , DEIGNAN, Jeffrey , DRANSFIELD, Paul John , DU, Xiaohui , FU, Zice , HEATH, Julie Anne , HORNE, Daniel B. , HOUZE, Jonathan , KALLER, Matthew R. , KHAKOO, Aarif Yusuf , KOPECKY, David John , LAI, Su-Jen , MA, Zhihua , MCGEE, Lawrence R. , MEDINA, Julio C. , MIHALIC, Jeffrey T. , NISHIMURA, Nobuko , OLSON, Steven H. , PATTAROPONG, Vatee , SWAMINATH, Gayathri , WANG, Xiaodong , YANG, Kevin , YEH, Wen-Chen , DEBENEDETTO, Mikkel V. , FARRELL, Robert P. , HEDLEY, Simon J. , JUDD, Ted C. , KAYSER, Frank
IPC: C07D401/14 , C07D401/04 , C07D413/04 , A61K31/4196 , A61K31/4439 , A61P9/00
CPC classification number: C07D401/14 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures where the definitions of the variables are provided herein.
Abstract translation: 式I和式II的化合物，其药学上可接受的盐，前述任何一种的立体异构体或其混合物是APJ受体的激动剂，并且可用于治疗心血管和其它病症。 式I和式II的化合物具有以下结构，其中本文提供变量的定义。
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公开(公告)号：EP3300500A1
公开(公告)日：2018-04-04
申请号：EP16730076.3
申请日：2016-05-18
Applicant: Amgen Inc.
Inventor： CHEN, Ning , CHEN, Xiaoqi , CHEN, Yinhong , CHENG, Alan C. , CONNORS, Richard V. , DEIGNAN, Jeffrey , DRANSFIELD, Paul John , DU, Xiaohui , FU, Zice , HEATH, Julie Anne , HORNE, Daniel B. , HOUZE, Jonathan , KALLER, Matthew R. , KHAKOO, Aarif Yusuf , KOPECKY, David John , LAI, Su-Jen , MA, Zhihua , MCGEE, Lawrence R. , MEDINA, Julio C. , MIHALIC, Jeffrey T. , NISHIMURA, Nobuko , OLSON, Steven H. , PATTAROPONG, Vatee , SWAMINATH, Gayathri , WANG, Xiaodong , YANG, Kevin , YEH, Wen-Chen , DEBENEDETTO, Mikkel V. , FARRELL, Robert P. , HEDLEY, Simon J. , JUDD, Ted C. , KAYSER, Frank
IPC: C07D401/14 , C07D401/04 , C07D413/04 , A61K31/4196 , A61K31/4439 , A61P9/00
CPC classification number: C07D401/14 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08
Abstract: where the definitions of the variables are provided herein.
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公开(公告)号：EP3452466A1
公开(公告)日：2019-03-13
申请号：EP17733197.2
申请日：2017-05-02
Applicant: Amgen Inc.
Inventor： CHEN, Xiaoqi , CHEN, Yinhong , CHENG, Alan C. , CONNORS, Richard V. , DEBENEDETTO, Mikkel V. , DRANSFIELD, Paul John , FU, Zice , HARVEY, James S. , HEATH, Julie Anne , HEDLEY, Simon J. , HOUZE, Jonathan , JUDD, Ted C. , KHAKOO, Aarif Yusuf , KOPECKY, David J. , LAI, Su-Jen , MA, Zhihua , NISHIMURA, Nobuko , OLSON, Steven H. , PATTAROPONG, Vatee , SWAMINATH, Gayathri , WANG, Xiaodong , YEH, Wen-Chen
IPC: C07D401/14 , C07D403/04 , C07D405/14 , C07D403/14 , C07D405/04 , C07D409/14 , C07D471/04 , A61K31/4196 , A61P9/00
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