公开(公告)号：EP1022985A1

公开(公告)日：2000-08-02

申请号：EP98948587.5

申请日：1998-09-29

Applicant: ANGIOSONICS INC.

Inventor： ROSENSCHEIN, Uri ,  ESHEL, Yoram ,  FURMAN, Vladimir ,  KERNER, Efim

IPC: A61B17/00

CPC classification number: A61B17/22012 ,  A61B2017/00106 ,  A61B2017/22007 ,  A61B2018/00011

Abstract: An apparatus and method for the application of ultrasound to a locations within the body are provided. The apparatus can advantageously operate at a pulse duration below about 100 milliseconds, in the range 0.1 milliseconds to 100 milliseconds, a pulse repetition period below about 1 second, and in the range of 1 millisecond to 1 second. The apparatus includes a therapeutic focused ultrasound transducer (110), activated by an electrical signal from a signal generator (120).

公开(公告)号：EP1169088A1

公开(公告)日：2002-01-09

申请号：EP00952781.3

申请日：2000-03-08

Applicant: ANGIOSONICS INC.

Inventor： ROSENSCHEIN, Uri ,  ESHEL, Yoram ,  FURMAN, Vladimir ,  KERNER, Efim ,  FABIAN, Izhak

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B17/2258

Abstract: An apparatus and method for the application of ultrasound to a location within the body is provided. A cavitation detection system is included so that the effectiveness, and safety of the ultrasound can be monitored during ultrasound treatment. A non-invasive ultrasound system (100) includes a therapeutic focused ultrasound transducer (110).

公开(公告)号：EP0983615A1

公开(公告)日：2000-03-08

申请号：EP98923552.8

申请日：1998-05-19

Applicant: ANGIOSONICS INC.

Inventor： WENG, Lee ,  POPOW, John ,  BELL, Phil ,  ROSENSCHEIN, Uri ,  KLEIN, Richard, B.

IPC: H01L41/08

CPC classification number: B06B1/0261 ,  B06B2201/55

Abstract: A control system for a probe, including a transmission member, comprises a power source for supplying a constant power to a transmission member and a transducer for coupling the constant power to the transmission member and for providing a mechanical output to the transmission member at a frequency. A frequency measuring device is also provided for constantly measuring the frequency of the mechanical output of the transducer. A current monitoring device for measuring current forwarded to the transducer which monitors the current while the frequency of said mechanical output is varied until it is determined at what frequency the current is at a maximum is also provided. A method for implementing this apparatus is also provided.

公开(公告)号：EP0895458A2

公开(公告)日：1999-02-10

申请号：EP98908520.0

申请日：1998-02-12

Applicant: ANGIOSONICS INC.

Inventor： LEVIN, Philip, S. ,  SALTONSTALL, Jon ,  NGUYEN, Loi ,  ROSENSCHEIN, Uri

IPC: A61B18 ,  A61B17 ,  G10K11 ,  A61B19

CPC classification number: A61B17/320068 ,  A61B17/22012 ,  A61B90/39 ,  A61B2017/22002 ,  A61B2017/320072 ,  A61B2018/00011 ,  G10K11/24

Abstract: An ultrasonic treatment system and method for utilizing ultrasound to treat intravascular conditions, such as stenotic and occluded regions of blood vessels, are provided. The ultrasonic treatment system includes an ultrasonic probe (100), having a proximal and distal end. A guide catheter and guidewire may also be provided and the probe (100) can be slidably disposed within the guide catheter's inner lumen. The probe can include a horn (125) at the proximal end, a transmission member (B, C, D, E) with a proximal and a distal end connected to the horn at the transmission member proximal end (B), and a distal tip (150) connected at the transmission member's distal end. The transmission member may include one or more transmission wires (C, E), having proximal and distal ends connected serially or in parallel.

公开(公告)号：EP1140289A1

公开(公告)日：2001-10-10

申请号：EP98964087.5

申请日：1998-12-18

Applicant: ANGIOSONICS INC.

Inventor： ROSENSCHEIN, Uri ,  ROZENSZAJN, L., Arie

IPC: A61N7/00

Abstract: A device and methods for inducing apoptosis in precancerous, cancerous, and hyper-proliferating cells by applying ultrasonic energy. The methods can include use of ultrasonic energy in combination with antioxidants, and/or conventional therapies such as hormonal therapy, radiation therapy or chemotherapy. The device for the ultrasonic energy can include an ultrasonic transducer (30) in a handpiece (40), an ultrasonic transmission wire (50) connected at its proximal end to the transducer (30), and having an ultrasonic tip (60) at its other end. Power is supplied by power generator (20).

公开(公告)号：EP1054633A1

公开(公告)日：2000-11-29

申请号：EP99904565.1

申请日：1999-02-03

Applicant: ANGIOSONICS INC.

Inventor： ROSENSCHEIN, Uri ,  ROZESZJAN, Arie

IPC: A61B17/22

CPC classification number: A61B17/22012 ,  A61B2017/22008 ,  A61B2017/22082 ,  A61B2017/22088 ,  A61M37/0092

Abstract: A system and method for inhibiting restenosis by compromising the migration, viability and adhesion of mammalian smooth muscle cells (SMC). The system includes an ultrasonic energy source; a transmitter for transmitting the ultrasonic energy to the SMC and a drug delivery spectrum for delivering drugs to the smooth mucles cells. This system and method is especially useful in the prevention of restenosis in a blood vessel of a mammal associated with the migration of SMC in the blood vessel following vascular intervention, such as angioplasty.