公开(公告)号：JP2014122241A

公开(公告)日：2014-07-03

申请号：JP2014065161

申请日：2014-03-27

Applicant: Array Biopharma Inc ,  アレイ バイオファーマ、インコーポレイテッド

Inventor： LAURENCE E BURGESS ,  CHRISTOPHER T CLARK ,  ADAM COOK ,  CHRISTOPHER P CORRETTE ,  ROBERT KIRK DELISLE ,  GEORGE A DOHERTY ,  KEVIN W HUNT ,  GANGHYEOK KIM ,  TODD ROMOFF

IPC: C07D311/66 ,  A61K31/353 ,  A61K31/36 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/453 ,  A61K31/506 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  C07D405/12 ,  C07D407/12

CPC classification number: C07D311/58 ,  C07D311/04 ,  C07D405/12 ,  C07D407/12

Abstract: PROBLEM TO BE SOLVED: To provide certain 6-substituted phenoxychroman carboxylic acid derivatives useful in the treatment and prevention of diseases.SOLUTION: A compound of the formula I (where A, A, W, L, G, R, R, R, Rand Rhave meanings shown in the specification) is a DP2 receptor modulator useful in the treatment of immune diseases. The compound is found out to be a DP2 antagonist and useful in the treatment of immune diseases such as asthma and allergic inflammation.

Abstract translation: 要解决的问题：提供一些可用于治疗和预防疾病的6-取代苯氧基苯并二氢吡喃羧酸衍生物。溶液：式I化合物（其中A，A，W，L，G，R，R，R， Rand Rhave意义在说明书中所示）是用于治疗免疫疾病的DP2受体调节剂。 该化合物被发现是DP2拮抗剂，可用于治疗免疫疾病如哮喘和过敏性炎症。

公开(公告)号：PH12014500079B1

公开(公告)日：2015-02-09

申请号：PH12014500079

申请日：2014-01-08

Applicant: ARRAY BIOPHARMA INC

Inventor： BURGESS LAURENCE E ,  CLARK CHRISTOPHER T ,  ADAM COOK ,  CORRETTE CHRISTOPHER P ,  KIRK DELISLE ROBERT ,  DOHERTY GEORGE A ,  HUNT KEVIN W ,  TODD ROMOFF ,  GANGHYEOK KIM

IPC: A61K31/353 ,  A61P29/00 ,  C07D311/04 ,  C07D405/12 ,  C07D407/12

Abstract: Compounds of Formula (I): in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.

公开(公告)号：PH12014500079A1

公开(公告)日：2015-02-09

申请号：PH12014500079

申请日：2014-01-08

Applicant: ARRAY BIOPHARMA INC

Inventor： BURGESS LAURENCE E ,  CLARK CHRISTOPHER T ,  ADAM COOK ,  CORRETTE CHRISTOPHER P ,  KIRK DELISLE ROBERT ,  DOHERTY GEORGE A ,  HUNT KEVIN W ,  TODD ROMOFF ,  GANGHYEOK KIM

IPC: A61P29/00 ,  A61K31/353 ,  C07D311/04 ,  C07D405/12 ,  C07D407/12

Abstract: Compounds of Formula (I): in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.

公开(公告)号：BRPI0915513B8

公开(公告)日：2021-05-25

申请号：BRPI0915513

申请日：2009-06-24

Applicant: ARRAY BIOPHARMA INC

Inventor： LAURENCE E BURGESS ,  ROBERT KIRK DELISLE ,  TODD ROMOFF ,  ADAM COOK ,  CHRISTOPHER P CORRETTE ,  CHRISTOPHER T CLARK ,  GANGHYEOK KIM ,  GEORGE A DOHERTY ,  KEVIN W HUNT

IPC: C07D311/04 ,  A61K31/353 ,  A61P29/00 ,  C07D405/12 ,  C07D407/12

Abstract: compostos derivados de ácido fenóxicromano carboxílico 6-substituído, composições farmacêuticas compreendendo os referidos compostos, uso dos mesmos, e processo para a preparação destes. a presente invenção refere-se a compostos da fórmula (i): em que a1, a2, w, l, g, r7a, r7b, r8 e r10 possuem os significados fornecidos no relatório descritivo e são moduladores do receptor dp2, úteis no tratamento de doenças imunológicas.

公开(公告)号：BRPI0915513B1

公开(公告)日：2019-11-19

申请号：BRPI0915513

申请日：2009-06-24

Applicant: ARRAY BIOPHARMA INC

Inventor： ADAM COOK ,  CHRISTOPHER P CORRETTE ,  CHRISTOPHER T CLARK ,  GANGHYEOK KIM ,  GEORGE A DOHERTY ,  KEVIN W HUNT ,  LAURENCE E BURGESS ,  ROBERT KIRK DELISLE ,  TODD ROMOFF

IPC: C07D311/04 ,  A61K31/353 ,  A61P29/00 ,  C07D405/12 ,  C07D407/12

Abstract: compostos derivados de ácido fenóxicromano carboxílico 6-substituído, composições farmacêuticas compreendendo os referidos compostos, uso dos mesmos, e processo para a preparação destes a presente invenção refere-se a compostos da fórmula (1):em que a 1, a2, w, l, g, r7ª, r7b, r8, r9 e r1º possuem os significados fornecidos no relatório descritivo e são moduladores do receptor dp2, úteis no tratamento de doenças imunológicas.

公开(公告)号：CR20110037A

公开(公告)日：2011-03-14

申请号：CR20110037

申请日：2011-01-21

Applicant: ARRAY BIOPHARMA INC

Inventor： LAURENCE E BURGESS ,  CHRISTOPHER T CLARK ,  ADAM COOK ,  CHRISTOPHER P CORRETTE ,  ROBERT KIRK DELISLE ,  GEORGE A DOHERTY ,  KEVIN W HUNT ,  TODD ROMOFF ,  GANGHYEOK KIM

IPC: C07D311/04 ,  A61K31/353 ,  A61P29/00 ,  C07D405/12 ,  C07D407/12

Abstract: Compuestos de la Fórmula I en donde A1, A2, W, L, G, R7a, R7b, R8, R9 y R10 tienen las definiciones que se dieron en la memoria descriptiva, son moduladores de receptor de DP2 que son útiles en el tratamiento de enfermedades inmunológicas.